Immunology of the GI Tract
The intestine is the largest digestive organ in the human body and one of the largest organs in contact with the outside world. In addition to digesting food to facilitate the absorption of nutrients, it has a variety of other functions, including the transmission of information and regulation of th...
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| Materialtyp: | Online |
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| Språk: | engelska |
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IntechOpen
2023
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| Länkar: | ONIX_20230215_9781803560878_319 |
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| description | The intestine is the largest digestive organ in the human body and one of the largest organs in contact with the outside world. In addition to digesting food to facilitate the absorption of nutrients, it has a variety of other functions, including the transmission of information and regulation of the metabolism. Due to its unique structure, the intestine is constantly exposed to various antigens and microbes. To protect the body from pathogens, while also maintaining a stable environment, the human intestinal tract has evolved unique regional immune characteristics maintained by the mature intestinal mucosal immune system. This intricate system involves intestinal epithelial cells, and intestinal lymphoid tissue composed of Peyer’s patches, isolated lymphoid follicles, mesenteric lymph nodes, and so on. The congenital and adaptive immune mechanisms created by the unique structure, function, and microenvironment of the intestine differ from those of the central and peripheral immune organs forming the regional immunity of the intestine. Intestinal flora also plays an important role in maintaining intestinal homeostasis, altering the structure and function of the immune system, reshaping the immune microenvironment, and promoting interference with the development of specific diseases. In fact, the immune function of the intestinal region directly affects the development of many intestine-specific diseases. However, the integrity of this function depends on the expression of congenital genes and the regulation of the neuroendocrine system. The microenvironment created by intestinal flora and its products also affects the immunity of the intestinal region. In early life, appropriate intestinal colonization by specific microflora stimulates the maturation of the intestinal mucosa-associated lymphoid tissue. If the appropriate intestinal flora fails to form during this life stage, the function of the intestinal immune system becomes impaired, leading to increased incidence and/or morbidity of certain intestinal diseases, including ulcerative colitis, Crohn’s disease, and others. |
| format | Online |
| id | doab-20.500.12854ir-97281 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-972812024-03-31T22:44:22Z Immunology of the GI Tract Rodrigo, Luis Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJH Gastroenterology The intestine is the largest digestive organ in the human body and one of the largest organs in contact with the outside world. In addition to digesting food to facilitate the absorption of nutrients, it has a variety of other functions, including the transmission of information and regulation of the metabolism. Due to its unique structure, the intestine is constantly exposed to various antigens and microbes. To protect the body from pathogens, while also maintaining a stable environment, the human intestinal tract has evolved unique regional immune characteristics maintained by the mature intestinal mucosal immune system. This intricate system involves intestinal epithelial cells, and intestinal lymphoid tissue composed of Peyer’s patches, isolated lymphoid follicles, mesenteric lymph nodes, and so on. The congenital and adaptive immune mechanisms created by the unique structure, function, and microenvironment of the intestine differ from those of the central and peripheral immune organs forming the regional immunity of the intestine. Intestinal flora also plays an important role in maintaining intestinal homeostasis, altering the structure and function of the immune system, reshaping the immune microenvironment, and promoting interference with the development of specific diseases. In fact, the immune function of the intestinal region directly affects the development of many intestine-specific diseases. However, the integrity of this function depends on the expression of congenital genes and the regulation of the neuroendocrine system. The microenvironment created by intestinal flora and its products also affects the immunity of the intestinal region. In early life, appropriate intestinal colonization by specific microflora stimulates the maturation of the intestinal mucosa-associated lymphoid tissue. If the appropriate intestinal flora fails to form during this life stage, the function of the intestinal immune system becomes impaired, leading to increased incidence and/or morbidity of certain intestinal diseases, including ulcerative colitis, Crohn’s disease, and others. 2023-02-15T14:55:14Z 2023-02-15T14:55:14Z 2022 book ONIX_20230215_9781803560878_319 9781803560878 9781803560861 9781803560885 https://directory.doabooks.org/handle/20.500.12854/97281 eng image/jpeg n/a https://www.intechopen.com/books/11740 https://mts.intechopen.com/storage/books/11740/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.101293 10.5772/intechopen.101293 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781803560878 9781803560861 9781803560885 IntechOpen 312 open access |
| spellingShingle | Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJH Gastroenterology Immunology of the GI Tract |
| title | Immunology of the GI Tract |
| title_full | Immunology of the GI Tract |
| title_fullStr | Immunology of the GI Tract |
| title_full_unstemmed | Immunology of the GI Tract |
| title_short | Immunology of the GI Tract |
| title_sort | immunology of the gi tract |
| topic | Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJH Gastroenterology |
| topic_facet | Clinical & internal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJH Gastroenterology |
| url | ONIX_20230215_9781803560878_319 |