BRCA1 and BRCA2 Mutations
Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pa...
Gorde:
| Formatua: | Online |
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| Hizkuntza: | ingelesa |
| Argitaratua: |
IntechOpen
2023
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| Gaiak: | |
| Sarrera elektronikoa: | ONIX_20230215_9781803568072_353 |
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| _version_ | 1869527770453770240 |
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| collection | Directory of Open Access Books |
| description | Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications. In this context, this book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants. |
| format | Online |
| id | doab-20.500.12854ir-97315 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-973152024-03-31T22:45:28Z BRCA1 and BRCA2 Mutations Valarmathi, Mani T. Pre-clinical medicine: basic sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications. In this context, this book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants. 2023-02-15T14:57:17Z 2023-02-15T14:57:17Z 2023 book ONIX_20230215_9781803568072_353 9781803568072 9781803568065 9781803568089 https://directory.doabooks.org/handle/20.500.12854/97315 eng image/jpeg n/a https://www.intechopen.com/books/11593 https://mts.intechopen.com/storage/books/11593/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.100842 10.5772/intechopen.100842 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781803568072 9781803568065 9781803568089 IntechOpen 134 open access |
| spellingShingle | Pre-clinical medicine: basic sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics BRCA1 and BRCA2 Mutations |
| title | BRCA1 and BRCA2 Mutations |
| title_full | BRCA1 and BRCA2 Mutations |
| title_fullStr | BRCA1 and BRCA2 Mutations |
| title_full_unstemmed | BRCA1 and BRCA2 Mutations |
| title_short | BRCA1 and BRCA2 Mutations |
| title_sort | brca1 and brca2 mutations |
| topic | Pre-clinical medicine: basic sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| topic_facet | Pre-clinical medicine: basic sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| url | ONIX_20230215_9781803568072_353 |