Diagnostic or Therapeutic Strategies for Pregnancy Complications
It is well known that pregnancy complications, including preeclampsia, preterm birth, stillbirth, and intrauterine growth restriction affect over 12% of all pregnancies worldwide. These complications negatively impact both maternal and neonatal health and have short- and long-term effects such as an...
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| Format: | Online |
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | ONIX_20230220_9783036548777_32 |
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| description | It is well known that pregnancy complications, including preeclampsia, preterm birth, stillbirth, and intrauterine growth restriction affect over 12% of all pregnancies worldwide. These complications negatively impact both maternal and neonatal health and have short- and long-term effects such as an increased risk of neurodevelopmental and cardiovascular diseases. Over the past decade, numerous groups have investigated the use of new and/or existing drugs to either prolong gestation, such as in cases of threatened preterm labour; alleviate hypertension in preeclampsia; or promote adequate blood flow and nutrient delivery to the placenta to facilitate growth in IUGR. The overarching goal has been to promote healthier pregnancies and neonatal health, but it has been difficult to translate this work into the clinical setting, with problems in terms of drug delivery, specificity, and importantly, the early diagnostic capacities for complications in pregnancy. This book focuses on the early detection, potential novel therapeutic targets, risk factors, maternal outcomes, and long-term consequences of this critical problem. |
| format | Online |
| id | doab-20.500.12854ir-97429 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-974292024-03-30T23:21:54Z Diagnostic or Therapeutic Strategies for Pregnancy Complications Heazell, Alexander Girard, Sylvie ultrasonography elastography uterine cervix term pregnancy parturition genotyping preeclampsia MMP-9 MMP-2 SNPs tocolytic preterm birth preterm labor neonate prematurity pregnancy therapeutic progesterone fetus sex as a biological variable sex differences pregnancy complications placenta prenatal diagnosis fetal growth restriction miscarriage chorio-deciduitis grade amnionitis acute histologic chorioamnionitis intra-amniotic inflammatory response beta-blocker endothelial dysfunction cardiovascular disease pregnancy loss immunology vascular endothelial growth factor galectin-9 interleukin-4 proteomics urine biomarkers IBP4 SHBG RPL NK cells sildenafil PDE5A VEGF-A angiotensin infant newborn female abruptio placentae Apgar score pregnant women gestational age IL-1 blockade anakinra canakinumab human inflammation fetal growth restriction (FGR) intra-uterine growth restriction (IUGR) SPINT1 HAI-1 stillbirth placental insufficiency histopathology cardiovascular risk postpartum screening n/a thema EDItEUR::M Medicine and Nursing It is well known that pregnancy complications, including preeclampsia, preterm birth, stillbirth, and intrauterine growth restriction affect over 12% of all pregnancies worldwide. These complications negatively impact both maternal and neonatal health and have short- and long-term effects such as an increased risk of neurodevelopmental and cardiovascular diseases. Over the past decade, numerous groups have investigated the use of new and/or existing drugs to either prolong gestation, such as in cases of threatened preterm labour; alleviate hypertension in preeclampsia; or promote adequate blood flow and nutrient delivery to the placenta to facilitate growth in IUGR. The overarching goal has been to promote healthier pregnancies and neonatal health, but it has been difficult to translate this work into the clinical setting, with problems in terms of drug delivery, specificity, and importantly, the early diagnostic capacities for complications in pregnancy. This book focuses on the early detection, potential novel therapeutic targets, risk factors, maternal outcomes, and long-term consequences of this critical problem. 2023-02-20T16:44:02Z 2023-02-20T16:44:02Z 2022 book ONIX_20230220_9783036548777_32 9783036548777 9783036548784 https://directory.doabooks.org/handle/20.500.12854/97429 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/5950 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-4878-4 10.3390/books978-3-0365-4878-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036548777 9783036548784 238 Basel open access |
| spellingShingle | ultrasonography elastography uterine cervix term pregnancy parturition genotyping preeclampsia MMP-9 MMP-2 SNPs tocolytic preterm birth preterm labor neonate prematurity pregnancy therapeutic progesterone fetus sex as a biological variable sex differences pregnancy complications placenta prenatal diagnosis fetal growth restriction miscarriage chorio-deciduitis grade amnionitis acute histologic chorioamnionitis intra-amniotic inflammatory response beta-blocker endothelial dysfunction cardiovascular disease pregnancy loss immunology vascular endothelial growth factor galectin-9 interleukin-4 proteomics urine biomarkers IBP4 SHBG RPL NK cells sildenafil PDE5A VEGF-A angiotensin infant newborn female abruptio placentae Apgar score pregnant women gestational age IL-1 blockade anakinra canakinumab human inflammation fetal growth restriction (FGR) intra-uterine growth restriction (IUGR) SPINT1 HAI-1 stillbirth placental insufficiency histopathology cardiovascular risk postpartum screening n/a thema EDItEUR::M Medicine and Nursing Diagnostic or Therapeutic Strategies for Pregnancy Complications |
| title | Diagnostic or Therapeutic Strategies for Pregnancy Complications |
| title_full | Diagnostic or Therapeutic Strategies for Pregnancy Complications |
| title_fullStr | Diagnostic or Therapeutic Strategies for Pregnancy Complications |
| title_full_unstemmed | Diagnostic or Therapeutic Strategies for Pregnancy Complications |
| title_short | Diagnostic or Therapeutic Strategies for Pregnancy Complications |
| title_sort | diagnostic or therapeutic strategies for pregnancy complications |
| topic | ultrasonography elastography uterine cervix term pregnancy parturition genotyping preeclampsia MMP-9 MMP-2 SNPs tocolytic preterm birth preterm labor neonate prematurity pregnancy therapeutic progesterone fetus sex as a biological variable sex differences pregnancy complications placenta prenatal diagnosis fetal growth restriction miscarriage chorio-deciduitis grade amnionitis acute histologic chorioamnionitis intra-amniotic inflammatory response beta-blocker endothelial dysfunction cardiovascular disease pregnancy loss immunology vascular endothelial growth factor galectin-9 interleukin-4 proteomics urine biomarkers IBP4 SHBG RPL NK cells sildenafil PDE5A VEGF-A angiotensin infant newborn female abruptio placentae Apgar score pregnant women gestational age IL-1 blockade anakinra canakinumab human inflammation fetal growth restriction (FGR) intra-uterine growth restriction (IUGR) SPINT1 HAI-1 stillbirth placental insufficiency histopathology cardiovascular risk postpartum screening n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | ultrasonography elastography uterine cervix term pregnancy parturition genotyping preeclampsia MMP-9 MMP-2 SNPs tocolytic preterm birth preterm labor neonate prematurity pregnancy therapeutic progesterone fetus sex as a biological variable sex differences pregnancy complications placenta prenatal diagnosis fetal growth restriction miscarriage chorio-deciduitis grade amnionitis acute histologic chorioamnionitis intra-amniotic inflammatory response beta-blocker endothelial dysfunction cardiovascular disease pregnancy loss immunology vascular endothelial growth factor galectin-9 interleukin-4 proteomics urine biomarkers IBP4 SHBG RPL NK cells sildenafil PDE5A VEGF-A angiotensin infant newborn female abruptio placentae Apgar score pregnant women gestational age IL-1 blockade anakinra canakinumab human inflammation fetal growth restriction (FGR) intra-uterine growth restriction (IUGR) SPINT1 HAI-1 stillbirth placental insufficiency histopathology cardiovascular risk postpartum screening n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230220_9783036548777_32 |