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Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy

Polypharmacy is a necessary and important aspect of drug treatment; however, it becomes a challenge when the medication risks outweigh the benefits for an individual patient. Drug–drug interactions and the introduction of prescribing cascades are common features of polypharmacy, which can lead to in...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2023
Subjects:
acute kidney injury
early biomarker
plasma neutrophil gelatinase-associated lipocalin
soluble urokinase plasminogen activator receptor
medication optimization
older patients
emergency department
multimorbidity
polypharmacy
potentially inappropriate medication use
older adults
prevalence
determinants
chronic
outpatient
2019 Beers criteria
Ethiopia
pharmacogenomics
persons with diabetes
drug–drug interactions
drug–gene interactions
cytochrome P450
SLCO1B1
drug interaction checkers
adverse drug reactions
pharmacogenetics
personalized medicine
phenprocoumon
DOACs
bleeding
thromboembolism
HLA
drug hypersensitivity
abacavir
allopurinol
flucloxacillin
antiepileptic drugs
cost-effectiveness
shared medication record
medication reconciliation
drug information service
hospital pharmacy service
electronic prescribing
electronic medical record
clinical pharmacist
CYP2D6
CYP2D7P
CYP2D8P
copy number variation
CNV
genotyping
5’nuclease assay
HRM
high resolution melting
drug metabolization
extracellular vesicles
exosomes
microvesicles
pharmacogene expression
medication review
deprescriptions
quality of life
aged
80 and over
nursing homes
deprescribing
medication-based risk score
health outcomes
cytochromes
CYP1A2
adverse drug reaction
antipsychotics
olanzapine
clozapine
loxapine
children
youth
digital decision-support
health services research
general practice
process evaluation
antidepressants
utility
population-based
appropriateness
medication adherence
digital health
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries
Online Access:ONIX_20230220_9783036551623_83
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