Pharmaceutical Crystals (Volume II)
The crystalline state is the most commonly used as an essential solid in active pharmaceutical ingredients (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines. Still, the core is crystal structure analysis, which reveals the molecular structure of essential...
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | ONIX_20230307_9783036554730_44 |
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| description | The crystalline state is the most commonly used as an essential solid in active pharmaceutical ingredients (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines. Still, the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. These properties should be understood in terms of molecular structures and interactions between molecules in crystals. Information on three-dimensional molecular structures also affords insights into the biological activity of molecules. The second reprint in the series, "Crystalline Pharmaceuticals (Volume II)" focused on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts and hydrates, and polymorph crystals, were reported with interest. Such crystal structures contributed to the latest studies that combine morphology, spectroscopic, theoretical calculation, and thermal analysis with the crystallographic study. Thus, this reprint highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure-property study of pharmaceutical crystals. The Guest Editors of this reprint hope the readers enjoy a wide variety of recent studies on "Crystalline Pharmaceuticals." |
| format | Online |
| id | doab-20.500.12854ir-98034 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-980342024-04-11T15:11:17Z Pharmaceutical Crystals (Volume II) Yonemochi, Etsuo Uekusa, Hidehiro anastrozole non-covalent interactions halogen bonding lp-π interactions DFT QTAIM synthesis crystal structure fenclorim antifungal activity pyrimidine enrofloxacin salts organic acids solubility methimazole 1,2-bis[(1-methyl-1H-imidazole-2-yl)thio]ethane solid-state forms hydrates dehydration disordered crystal structure hydrogen bonding in silico docking Hirshfeld surface NF-κB signaling IKKβ inhibitor venetoclax crystals hydrate conformation X-ray diffraction nanocrystalline materials physicochemical characterization vibrational spectroscopy X-ray analysis thermal analysis critical quality attributes Disopyramide Terephthalic acid salt molecular packing slurry crystallization disopyramide phthalic acid metastable crystal structure analysis diclofenac diclofenac sodium hydration–dehydration mechanism anhydrate thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology The crystalline state is the most commonly used as an essential solid in active pharmaceutical ingredients (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines. Still, the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. These properties should be understood in terms of molecular structures and interactions between molecules in crystals. Information on three-dimensional molecular structures also affords insights into the biological activity of molecules. The second reprint in the series, "Crystalline Pharmaceuticals (Volume II)" focused on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts and hydrates, and polymorph crystals, were reported with interest. Such crystal structures contributed to the latest studies that combine morphology, spectroscopic, theoretical calculation, and thermal analysis with the crystallographic study. Thus, this reprint highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure-property study of pharmaceutical crystals. The Guest Editors of this reprint hope the readers enjoy a wide variety of recent studies on "Crystalline Pharmaceuticals." 2023-03-07T16:30:12Z 2023-03-07T16:30:12Z 2023 book ONIX_20230307_9783036554730_44 9783036554730 9783036554747 https://directory.doabooks.org/handle/20.500.12854/98034 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/6761 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-5474-7 10.3390/books978-3-0365-5474-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036554730 9783036554747 176 Basel open access |
| spellingShingle | anastrozole non-covalent interactions halogen bonding lp-π interactions DFT QTAIM synthesis crystal structure fenclorim antifungal activity pyrimidine enrofloxacin salts organic acids solubility methimazole 1,2-bis[(1-methyl-1H-imidazole-2-yl)thio]ethane solid-state forms hydrates dehydration disordered crystal structure hydrogen bonding in silico docking Hirshfeld surface NF-κB signaling IKKβ inhibitor venetoclax crystals hydrate conformation X-ray diffraction nanocrystalline materials physicochemical characterization vibrational spectroscopy X-ray analysis thermal analysis critical quality attributes Disopyramide Terephthalic acid salt molecular packing slurry crystallization disopyramide phthalic acid metastable crystal structure analysis diclofenac diclofenac sodium hydration–dehydration mechanism anhydrate thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology Pharmaceutical Crystals (Volume II) |
| title | Pharmaceutical Crystals (Volume II) |
| title_full | Pharmaceutical Crystals (Volume II) |
| title_fullStr | Pharmaceutical Crystals (Volume II) |
| title_full_unstemmed | Pharmaceutical Crystals (Volume II) |
| title_short | Pharmaceutical Crystals (Volume II) |
| title_sort | pharmaceutical crystals volume ii |
| topic | anastrozole non-covalent interactions halogen bonding lp-π interactions DFT QTAIM synthesis crystal structure fenclorim antifungal activity pyrimidine enrofloxacin salts organic acids solubility methimazole 1,2-bis[(1-methyl-1H-imidazole-2-yl)thio]ethane solid-state forms hydrates dehydration disordered crystal structure hydrogen bonding in silico docking Hirshfeld surface NF-κB signaling IKKβ inhibitor venetoclax crystals hydrate conformation X-ray diffraction nanocrystalline materials physicochemical characterization vibrational spectroscopy X-ray analysis thermal analysis critical quality attributes Disopyramide Terephthalic acid salt molecular packing slurry crystallization disopyramide phthalic acid metastable crystal structure analysis diclofenac diclofenac sodium hydration–dehydration mechanism anhydrate thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology |
| topic_facet | anastrozole non-covalent interactions halogen bonding lp-π interactions DFT QTAIM synthesis crystal structure fenclorim antifungal activity pyrimidine enrofloxacin salts organic acids solubility methimazole 1,2-bis[(1-methyl-1H-imidazole-2-yl)thio]ethane solid-state forms hydrates dehydration disordered crystal structure hydrogen bonding in silico docking Hirshfeld surface NF-κB signaling IKKβ inhibitor venetoclax crystals hydrate conformation X-ray diffraction nanocrystalline materials physicochemical characterization vibrational spectroscopy X-ray analysis thermal analysis critical quality attributes Disopyramide Terephthalic acid salt molecular packing slurry crystallization disopyramide phthalic acid metastable crystal structure analysis diclofenac diclofenac sodium hydration–dehydration mechanism anhydrate thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology |
| url | ONIX_20230307_9783036554730_44 |