Pathogenesis and Targeted Therapy of Epilepsy
Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respon...
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| Format: | Online |
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online-Zugang: | ONIX_20230405_9783036564364_11 |
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| description | Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression. |
| format | Online |
| id | doab-20.500.12854ir-98732 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-987322024-03-31T13:08:30Z Pathogenesis and Targeted Therapy of Epilepsy N'Gouemo, Prosper 3CAI GRIA1 GRIA2 intractable epilepsy PICK1 protein kinase C pericytes mural cells cytokine blood-brain barrier neuroinflammation 3-phosphoinositide-dependent protein kinase-1 AKT cyclosporin A GluA1 GluR1 PDK1 refractory seizure temporal lobe epilepsy hippocampus 4-aminopyridine epilepsy model long-term potentiation AMPA receptor audiogenic epilepsy rodents fear reaction behavior genetics c-Fos early gene activation epileptogenesis lipopolysaccharide pentylenetetrazole post-traumatic epilepsy seizure susceptibility traumatic brain injury epilepsy ghrelin ghrelin receptor anxiety TRPV1 channels neuronal activity neuropsychiatric comorbidity immunofluorescence audiogenic kindling acoustically evoked seizures EACT generalized tonic-clonic seizures inherited epilepsy TMEM1A channels wild running seizures astrocyte ML365 pharmacoresistant epilepsy cortical atrophy hippocampal atrophy intracerebral electrode magnetic resonance imaging posttraumatic epilepsy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression. 2023-04-05T12:48:14Z 2023-04-05T12:48:14Z 2023 book ONIX_20230405_9783036564364_11 9783036564364 9783036564371 https://directory.doabooks.org/handle/20.500.12854/98732 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/6739 https://mdpi.com/books/pdfview/book/6739 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6437-1 10.3390/books978-3-0365-6437-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036564364 9783036564371 236 Basel open access |
| spellingShingle | 3CAI GRIA1 GRIA2 intractable epilepsy PICK1 protein kinase C pericytes mural cells cytokine blood-brain barrier neuroinflammation 3-phosphoinositide-dependent protein kinase-1 AKT cyclosporin A GluA1 GluR1 PDK1 refractory seizure temporal lobe epilepsy hippocampus 4-aminopyridine epilepsy model long-term potentiation AMPA receptor audiogenic epilepsy rodents fear reaction behavior genetics c-Fos early gene activation epileptogenesis lipopolysaccharide pentylenetetrazole post-traumatic epilepsy seizure susceptibility traumatic brain injury epilepsy ghrelin ghrelin receptor anxiety TRPV1 channels neuronal activity neuropsychiatric comorbidity immunofluorescence audiogenic kindling acoustically evoked seizures EACT generalized tonic-clonic seizures inherited epilepsy TMEM1A channels wild running seizures astrocyte ML365 pharmacoresistant epilepsy cortical atrophy hippocampal atrophy intracerebral electrode magnetic resonance imaging posttraumatic epilepsy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Pathogenesis and Targeted Therapy of Epilepsy |
| title | Pathogenesis and Targeted Therapy of Epilepsy |
| title_full | Pathogenesis and Targeted Therapy of Epilepsy |
| title_fullStr | Pathogenesis and Targeted Therapy of Epilepsy |
| title_full_unstemmed | Pathogenesis and Targeted Therapy of Epilepsy |
| title_short | Pathogenesis and Targeted Therapy of Epilepsy |
| title_sort | pathogenesis and targeted therapy of epilepsy |
| topic | 3CAI GRIA1 GRIA2 intractable epilepsy PICK1 protein kinase C pericytes mural cells cytokine blood-brain barrier neuroinflammation 3-phosphoinositide-dependent protein kinase-1 AKT cyclosporin A GluA1 GluR1 PDK1 refractory seizure temporal lobe epilepsy hippocampus 4-aminopyridine epilepsy model long-term potentiation AMPA receptor audiogenic epilepsy rodents fear reaction behavior genetics c-Fos early gene activation epileptogenesis lipopolysaccharide pentylenetetrazole post-traumatic epilepsy seizure susceptibility traumatic brain injury epilepsy ghrelin ghrelin receptor anxiety TRPV1 channels neuronal activity neuropsychiatric comorbidity immunofluorescence audiogenic kindling acoustically evoked seizures EACT generalized tonic-clonic seizures inherited epilepsy TMEM1A channels wild running seizures astrocyte ML365 pharmacoresistant epilepsy cortical atrophy hippocampal atrophy intracerebral electrode magnetic resonance imaging posttraumatic epilepsy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | 3CAI GRIA1 GRIA2 intractable epilepsy PICK1 protein kinase C pericytes mural cells cytokine blood-brain barrier neuroinflammation 3-phosphoinositide-dependent protein kinase-1 AKT cyclosporin A GluA1 GluR1 PDK1 refractory seizure temporal lobe epilepsy hippocampus 4-aminopyridine epilepsy model long-term potentiation AMPA receptor audiogenic epilepsy rodents fear reaction behavior genetics c-Fos early gene activation epileptogenesis lipopolysaccharide pentylenetetrazole post-traumatic epilepsy seizure susceptibility traumatic brain injury epilepsy ghrelin ghrelin receptor anxiety TRPV1 channels neuronal activity neuropsychiatric comorbidity immunofluorescence audiogenic kindling acoustically evoked seizures EACT generalized tonic-clonic seizures inherited epilepsy TMEM1A channels wild running seizures astrocyte ML365 pharmacoresistant epilepsy cortical atrophy hippocampal atrophy intracerebral electrode magnetic resonance imaging posttraumatic epilepsy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20230405_9783036564364_11 |