Frontiers in Protein Structure Research
In this Special Issue, we aim to represent the vibrant state of protein structure studies at the end of 2021. Recent decades have brought significant changes to the protein structure research field. Thanks to the genome projects and advances in structure determination methods, the number of solved p...
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| Μορφή: | Online |
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| Γλώσσα: | Αγγλικά |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Θέματα: | |
| Διαθέσιμο Online: | ONIX_20230405_9783036567815_93 |
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| _version_ | 1869518966230089728 |
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| collection | Directory of Open Access Books |
| description | In this Special Issue, we aim to represent the vibrant state of protein structure studies at the end of 2021. Recent decades have brought significant changes to the protein structure research field. Thanks to the genome projects and advances in structure determination methods, the number of solved protein structures has increased significantly. Protein structure research is experiencing a new renaissance, and in 2020 the number of deposited structures in the PDB database reached a new record. An assortment of many new frontiers are presented in this collection. A single Special Issue cannot give a comprehensive overview of a large field such as proteins science, but we aim to give a broad overview of current research. |
| format | Online |
| id | doab-20.500.12854ir-98814 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-988142024-03-28T03:33:25Z Frontiers in Protein Structure Research Simon, Istvan Magyar, Csaba configurational entropy force fields intrinsically disordered proteins protein folding NMR high hydrostatic pressure thermodynamic stability α-helical bundle Li-Fraumeni syndrome hereditary breast cancer germline TP53 missense variants quantitative prediction model protein conformation protein–protein interactions protein–protein binding protein–protein complex coarse-grained modeling multiscale modeling UFM1 UBA5 UFC1 protein-protein interactions complex structure oxidative stress Nrf2 Keap1 nuclear magnetic resonance spectroscopy hydrogen/deuterium exchange mass spectrometry circular dichroism intrinsically disordered bifidobacteria fucosidases glycosyl hydrolases conserved domains human milk analytical ultracentrifugation CO2 concentrating mechanism diffusion-ordered NMR spectroscopy electrospray ionization mass spectrometry homotetramer manganese metalloprotein photosynthesis small-angle X-ray scattering C1q calcium binding proteins genetic variation otoconia otolin-1 OTOL1 site-directed mutagenesis thermal shift assay B.1.1.7 B.1.617.2 COVID-19 E484Q T478K and L452R mutation N501Y mutation spike protein tetrabromobisphenol A tetrabromobisphenol S erythrocyte membrane retardants erythrocytes protein–ligand interactions protein dynamics FK506-binding protein FKBP12 FKBP51 oxidative folding glutathionylation nitrosylation cysteine reactivity ribosomal exit tunnel transient complex glutathione phosphorylation transmembrane proteins saturation mutagenesis deep sequencing residue packing deep learning convolutional neural network bidirectional long-short term memory protein prediction contact distance alphafold ProSPr CASP dataset retrainable mutual synergetic folding solvent accessibility of peptide bonds inter-subunit interaction solvent-accessible surface area Shannon information entropy amino acid composition glucose GlcNAc galactose GalNAc mannose xylose fucose Neu5Ac glucuronate iduronate tetrahydropyran entropy free energy free energy landscape energy-dependent protein folding co-translational protein folding molecular chaperones physical model of protein folding n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences In this Special Issue, we aim to represent the vibrant state of protein structure studies at the end of 2021. Recent decades have brought significant changes to the protein structure research field. Thanks to the genome projects and advances in structure determination methods, the number of solved protein structures has increased significantly. Protein structure research is experiencing a new renaissance, and in 2020 the number of deposited structures in the PDB database reached a new record. An assortment of many new frontiers are presented in this collection. A single Special Issue cannot give a comprehensive overview of a large field such as proteins science, but we aim to give a broad overview of current research. 2023-04-05T12:52:27Z 2023-04-05T12:52:27Z 2023 book ONIX_20230405_9783036567815_93 9783036567815 9783036567808 https://directory.doabooks.org/handle/20.500.12854/98814 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/6860 https://mdpi.com/books/pdfview/book/6860 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6780-8 10.3390/books978-3-0365-6780-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036567815 9783036567808 352 Basel open access |
| spellingShingle | configurational entropy force fields intrinsically disordered proteins protein folding NMR high hydrostatic pressure thermodynamic stability α-helical bundle Li-Fraumeni syndrome hereditary breast cancer germline TP53 missense variants quantitative prediction model protein conformation protein–protein interactions protein–protein binding protein–protein complex coarse-grained modeling multiscale modeling UFM1 UBA5 UFC1 protein-protein interactions complex structure oxidative stress Nrf2 Keap1 nuclear magnetic resonance spectroscopy hydrogen/deuterium exchange mass spectrometry circular dichroism intrinsically disordered bifidobacteria fucosidases glycosyl hydrolases conserved domains human milk analytical ultracentrifugation CO2 concentrating mechanism diffusion-ordered NMR spectroscopy electrospray ionization mass spectrometry homotetramer manganese metalloprotein photosynthesis small-angle X-ray scattering C1q calcium binding proteins genetic variation otoconia otolin-1 OTOL1 site-directed mutagenesis thermal shift assay B.1.1.7 B.1.617.2 COVID-19 E484Q T478K and L452R mutation N501Y mutation spike protein tetrabromobisphenol A tetrabromobisphenol S erythrocyte membrane retardants erythrocytes protein–ligand interactions protein dynamics FK506-binding protein FKBP12 FKBP51 oxidative folding glutathionylation nitrosylation cysteine reactivity ribosomal exit tunnel transient complex glutathione phosphorylation transmembrane proteins saturation mutagenesis deep sequencing residue packing deep learning convolutional neural network bidirectional long-short term memory protein prediction contact distance alphafold ProSPr CASP dataset retrainable mutual synergetic folding solvent accessibility of peptide bonds inter-subunit interaction solvent-accessible surface area Shannon information entropy amino acid composition glucose GlcNAc galactose GalNAc mannose xylose fucose Neu5Ac glucuronate iduronate tetrahydropyran entropy free energy free energy landscape energy-dependent protein folding co-translational protein folding molecular chaperones physical model of protein folding n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Frontiers in Protein Structure Research |
| title | Frontiers in Protein Structure Research |
| title_full | Frontiers in Protein Structure Research |
| title_fullStr | Frontiers in Protein Structure Research |
| title_full_unstemmed | Frontiers in Protein Structure Research |
| title_short | Frontiers in Protein Structure Research |
| title_sort | frontiers in protein structure research |
| topic | configurational entropy force fields intrinsically disordered proteins protein folding NMR high hydrostatic pressure thermodynamic stability α-helical bundle Li-Fraumeni syndrome hereditary breast cancer germline TP53 missense variants quantitative prediction model protein conformation protein–protein interactions protein–protein binding protein–protein complex coarse-grained modeling multiscale modeling UFM1 UBA5 UFC1 protein-protein interactions complex structure oxidative stress Nrf2 Keap1 nuclear magnetic resonance spectroscopy hydrogen/deuterium exchange mass spectrometry circular dichroism intrinsically disordered bifidobacteria fucosidases glycosyl hydrolases conserved domains human milk analytical ultracentrifugation CO2 concentrating mechanism diffusion-ordered NMR spectroscopy electrospray ionization mass spectrometry homotetramer manganese metalloprotein photosynthesis small-angle X-ray scattering C1q calcium binding proteins genetic variation otoconia otolin-1 OTOL1 site-directed mutagenesis thermal shift assay B.1.1.7 B.1.617.2 COVID-19 E484Q T478K and L452R mutation N501Y mutation spike protein tetrabromobisphenol A tetrabromobisphenol S erythrocyte membrane retardants erythrocytes protein–ligand interactions protein dynamics FK506-binding protein FKBP12 FKBP51 oxidative folding glutathionylation nitrosylation cysteine reactivity ribosomal exit tunnel transient complex glutathione phosphorylation transmembrane proteins saturation mutagenesis deep sequencing residue packing deep learning convolutional neural network bidirectional long-short term memory protein prediction contact distance alphafold ProSPr CASP dataset retrainable mutual synergetic folding solvent accessibility of peptide bonds inter-subunit interaction solvent-accessible surface area Shannon information entropy amino acid composition glucose GlcNAc galactose GalNAc mannose xylose fucose Neu5Ac glucuronate iduronate tetrahydropyran entropy free energy free energy landscape energy-dependent protein folding co-translational protein folding molecular chaperones physical model of protein folding n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | configurational entropy force fields intrinsically disordered proteins protein folding NMR high hydrostatic pressure thermodynamic stability α-helical bundle Li-Fraumeni syndrome hereditary breast cancer germline TP53 missense variants quantitative prediction model protein conformation protein–protein interactions protein–protein binding protein–protein complex coarse-grained modeling multiscale modeling UFM1 UBA5 UFC1 protein-protein interactions complex structure oxidative stress Nrf2 Keap1 nuclear magnetic resonance spectroscopy hydrogen/deuterium exchange mass spectrometry circular dichroism intrinsically disordered bifidobacteria fucosidases glycosyl hydrolases conserved domains human milk analytical ultracentrifugation CO2 concentrating mechanism diffusion-ordered NMR spectroscopy electrospray ionization mass spectrometry homotetramer manganese metalloprotein photosynthesis small-angle X-ray scattering C1q calcium binding proteins genetic variation otoconia otolin-1 OTOL1 site-directed mutagenesis thermal shift assay B.1.1.7 B.1.617.2 COVID-19 E484Q T478K and L452R mutation N501Y mutation spike protein tetrabromobisphenol A tetrabromobisphenol S erythrocyte membrane retardants erythrocytes protein–ligand interactions protein dynamics FK506-binding protein FKBP12 FKBP51 oxidative folding glutathionylation nitrosylation cysteine reactivity ribosomal exit tunnel transient complex glutathione phosphorylation transmembrane proteins saturation mutagenesis deep sequencing residue packing deep learning convolutional neural network bidirectional long-short term memory protein prediction contact distance alphafold ProSPr CASP dataset retrainable mutual synergetic folding solvent accessibility of peptide bonds inter-subunit interaction solvent-accessible surface area Shannon information entropy amino acid composition glucose GlcNAc galactose GalNAc mannose xylose fucose Neu5Ac glucuronate iduronate tetrahydropyran entropy free energy free energy landscape energy-dependent protein folding co-translational protein folding molecular chaperones physical model of protein folding n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230405_9783036567815_93 |