A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology
This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Предметы: | |
| Online-ссылка: | ONIX_20230405_9783036569185_181 |
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| _version_ | 1869522651550056448 |
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| collection | Directory of Open Access Books |
| description | This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today’s vitamin D biology, from evolution to systems biology. |
| format | Online |
| id | doab-20.500.12854ir-98902 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-989022024-03-31T13:10:33Z A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology Carlberg, Carsten vitamin D VDR target genes chromatin epigenome transcriptome vitamin D signaling 25-hydroxyvitamin D 1,25-(OH)2D3 antitumor action breast cancer case-control studies colorectal cancer cohort studies ecological studies epidemiological studies randomized controlled trials UVB vitamin D receptor 3D structure structural analysis molecular recognition protein–ligand interactions coregulators acute myeloid leukemia blast 1,25-dihydroxyvitamin D analogs all-trans-retinoic acid differentiation immunomodulation evolution energy metabolism immune system calcium homeostasis migration of Homo sapiens influenza SARS-CoV-2 lung inflammation infantile hypercalcemia type 1 idiopathic infantile hypercalcemia CYP24A1 25-hydroxyvitamin D 24-hydroxylase hypercalcemia 24,25-dihydroxyvitamin D3 fracture repair diet transcellular absorption diffusion intestine homeostasis parathyroid hormone gestational diabetes preeclampsia preterm birth ovarian cancer vitamin D analogs vitamin D deficiency single high dose vitamin D3 supplementation proinflammatory cytokines IL6 IL8 TNF 25(OH)D3 brain development neuroprotection disease mechanisms genetic risk heritability personalized supplementation genome-wide association study Mendelian randomization lumisterol anti-inflammatory ACE2 Mpro RdRp month of birth muscle pregnancy older adults metabolites hybrids and VDR nonsecosteroidal ligands nongenomic response PDIA3 ultraviolet radiation megalin mitochondria vitamin D metabolism fibroblast growth factor-23 klotho 1α-hydroxylase RAAS systems biology cell differentiation prostate cancer n/a bone osteoblasts differentiation and mineralization McCollum sunlight rickets food fortification vitamin D2 vitamin D3 COVID-19 thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today’s vitamin D biology, from evolution to systems biology. 2023-04-05T12:58:16Z 2023-04-05T12:58:16Z 2023 book ONIX_20230405_9783036569185_181 9783036569185 9783036569192 https://directory.doabooks.org/handle/20.500.12854/98902 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/6955 https://mdpi.com/books/pdfview/book/6955 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6919-2 10.3390/books978-3-0365-6919-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036569185 9783036569192 414 Basel open access |
| spellingShingle | vitamin D VDR target genes chromatin epigenome transcriptome vitamin D signaling 25-hydroxyvitamin D 1,25-(OH)2D3 antitumor action breast cancer case-control studies colorectal cancer cohort studies ecological studies epidemiological studies randomized controlled trials UVB vitamin D receptor 3D structure structural analysis molecular recognition protein–ligand interactions coregulators acute myeloid leukemia blast 1,25-dihydroxyvitamin D analogs all-trans-retinoic acid differentiation immunomodulation evolution energy metabolism immune system calcium homeostasis migration of Homo sapiens influenza SARS-CoV-2 lung inflammation infantile hypercalcemia type 1 idiopathic infantile hypercalcemia CYP24A1 25-hydroxyvitamin D 24-hydroxylase hypercalcemia 24,25-dihydroxyvitamin D3 fracture repair diet transcellular absorption diffusion intestine homeostasis parathyroid hormone gestational diabetes preeclampsia preterm birth ovarian cancer vitamin D analogs vitamin D deficiency single high dose vitamin D3 supplementation proinflammatory cytokines IL6 IL8 TNF 25(OH)D3 brain development neuroprotection disease mechanisms genetic risk heritability personalized supplementation genome-wide association study Mendelian randomization lumisterol anti-inflammatory ACE2 Mpro RdRp month of birth muscle pregnancy older adults metabolites hybrids and VDR nonsecosteroidal ligands nongenomic response PDIA3 ultraviolet radiation megalin mitochondria vitamin D metabolism fibroblast growth factor-23 klotho 1α-hydroxylase RAAS systems biology cell differentiation prostate cancer n/a bone osteoblasts differentiation and mineralization McCollum sunlight rickets food fortification vitamin D2 vitamin D3 COVID-19 thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology |
| title | A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology |
| title_full | A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology |
| title_fullStr | A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology |
| title_full_unstemmed | A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology |
| title_short | A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology |
| title_sort | commemorative issue in honor of centennial of the discovery of vitamin d the central role of vitamin d in physiology |
| topic | vitamin D VDR target genes chromatin epigenome transcriptome vitamin D signaling 25-hydroxyvitamin D 1,25-(OH)2D3 antitumor action breast cancer case-control studies colorectal cancer cohort studies ecological studies epidemiological studies randomized controlled trials UVB vitamin D receptor 3D structure structural analysis molecular recognition protein–ligand interactions coregulators acute myeloid leukemia blast 1,25-dihydroxyvitamin D analogs all-trans-retinoic acid differentiation immunomodulation evolution energy metabolism immune system calcium homeostasis migration of Homo sapiens influenza SARS-CoV-2 lung inflammation infantile hypercalcemia type 1 idiopathic infantile hypercalcemia CYP24A1 25-hydroxyvitamin D 24-hydroxylase hypercalcemia 24,25-dihydroxyvitamin D3 fracture repair diet transcellular absorption diffusion intestine homeostasis parathyroid hormone gestational diabetes preeclampsia preterm birth ovarian cancer vitamin D analogs vitamin D deficiency single high dose vitamin D3 supplementation proinflammatory cytokines IL6 IL8 TNF 25(OH)D3 brain development neuroprotection disease mechanisms genetic risk heritability personalized supplementation genome-wide association study Mendelian randomization lumisterol anti-inflammatory ACE2 Mpro RdRp month of birth muscle pregnancy older adults metabolites hybrids and VDR nonsecosteroidal ligands nongenomic response PDIA3 ultraviolet radiation megalin mitochondria vitamin D metabolism fibroblast growth factor-23 klotho 1α-hydroxylase RAAS systems biology cell differentiation prostate cancer n/a bone osteoblasts differentiation and mineralization McCollum sunlight rickets food fortification vitamin D2 vitamin D3 COVID-19 thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | vitamin D VDR target genes chromatin epigenome transcriptome vitamin D signaling 25-hydroxyvitamin D 1,25-(OH)2D3 antitumor action breast cancer case-control studies colorectal cancer cohort studies ecological studies epidemiological studies randomized controlled trials UVB vitamin D receptor 3D structure structural analysis molecular recognition protein–ligand interactions coregulators acute myeloid leukemia blast 1,25-dihydroxyvitamin D analogs all-trans-retinoic acid differentiation immunomodulation evolution energy metabolism immune system calcium homeostasis migration of Homo sapiens influenza SARS-CoV-2 lung inflammation infantile hypercalcemia type 1 idiopathic infantile hypercalcemia CYP24A1 25-hydroxyvitamin D 24-hydroxylase hypercalcemia 24,25-dihydroxyvitamin D3 fracture repair diet transcellular absorption diffusion intestine homeostasis parathyroid hormone gestational diabetes preeclampsia preterm birth ovarian cancer vitamin D analogs vitamin D deficiency single high dose vitamin D3 supplementation proinflammatory cytokines IL6 IL8 TNF 25(OH)D3 brain development neuroprotection disease mechanisms genetic risk heritability personalized supplementation genome-wide association study Mendelian randomization lumisterol anti-inflammatory ACE2 Mpro RdRp month of birth muscle pregnancy older adults metabolites hybrids and VDR nonsecosteroidal ligands nongenomic response PDIA3 ultraviolet radiation megalin mitochondria vitamin D metabolism fibroblast growth factor-23 klotho 1α-hydroxylase RAAS systems biology cell differentiation prostate cancer n/a bone osteoblasts differentiation and mineralization McCollum sunlight rickets food fortification vitamin D2 vitamin D3 COVID-19 thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | ONIX_20230405_9783036569185_181 |