Challenges and Opportunities for Effective Cancer Immunotherapies
Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockad...
Wedi'i Gadw mewn:
| Fformat: | Online |
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| Iaith: | Saesneg |
| Cyhoeddwyd: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Pynciau: | |
| Mynediad Ar-lein: | ONIX_20230405_9783036569604_226 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869520627819347968 |
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| collection | Directory of Open Access Books |
| description | Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockades have emerged as the most effective treatments for certain cancers. The current challenge for cancer immunotherapies is that although some patients have benefited from the treatments, a number of cancers are resistant. The purpose of this Special Issue is to understand anti-cancer immunotherapy treatment resistance mechanisms and explore new options to provide opportunities for effective treatments. |
| format | Online |
| id | doab-20.500.12854ir-98947 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-989472024-03-30T23:22:42Z Challenges and Opportunities for Effective Cancer Immunotherapies Kershaw, Michael Slaney, Clare near infrared photoimmunotherapy monoclonal antibodies CD44 interleukin-15 cancer antigen processing and presentation cancer immunotherapy cross-priming immunogenicity major histocompatibility complex T lymphocyte tumor-infiltrating lymphocytes tumor microenvironment tumor-specific antigen pancreatic tumor NK cell immunosurveillance NKG2D histon (de)acetylation immunotherapy PD-1 microenvironment CAR T cells immune checkpoint inhibitors cervical cancer immune checkpoint inhibitor pembrolizumab recurrence pattern-recognition receptors toll-like receptors intratumoural tumour microenvironment NKG2D ligands NKG2D receptor NK cells immune evasion convergent evolution viruses glioblastoma model animal model preclinical murine immune response GBM newcastle disease virus modulated electrohyperthermia dendritic cell vaccination clinical trial individualized multimodal immunotherapy CAR-T cell therapy CD19 clinical trials CRS toxicity immunocyte membrane-coated nanoparticles biomimicry macrophage T-cell natural killer dendritic cell IL-12 family cytokines anti-tumor immunity STAT B cell T cell antibody therapy immuno-oncology CD3-bispecific antibody T-cell engager solid tumors on-target off-tumor toxicity T-cell co-stimulation tumor-associated antigens chimeric antigen receptor immune cell endodomain combination therapy TNFα adoptive cell therapy monoclonal antibody radiotherapy local ablation therapies checkpoint inhibitors chemotherapy protein kinase inhibitors oncolytic virus anti-cancer therapies T cell receptor chimeric antigen receptor (CAR) T cell (CAR-T) signal transduction CD8 coreceptor signaling kinetics oligomerization TAM receptors Axl MerTK small molecule inhibitors CAR T cell therapy T cell metabolism mitochondria memory T cell metabolic reprogramming adipose tissue-derived stem cells (ADSCs) mesenchymal stem cells myxoma virus oncolytic virotherapy pancreatic ductal adenocarcinoma Flt3 Flt3L dendritic cells HER2-positive breast cancer immune checkpoint blockade immune checkpoint molecules PD-1/PD-L1 melanoma tumour antigens Ropporin-1 ROPN1 Ropporin-1B ROPN1B nonreplicating adenovirus vector gene therapy routes of delivery virus coated with cancer cell membrane adoptive cell transfer targeted therapy cell cycle n/a thema EDItEUR::M Medicine and Nursing Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockades have emerged as the most effective treatments for certain cancers. The current challenge for cancer immunotherapies is that although some patients have benefited from the treatments, a number of cancers are resistant. The purpose of this Special Issue is to understand anti-cancer immunotherapy treatment resistance mechanisms and explore new options to provide opportunities for effective treatments. 2023-04-05T13:00:27Z 2023-04-05T13:00:27Z 2023 book ONIX_20230405_9783036569604_226 9783036569604 9783036569611 https://directory.doabooks.org/handle/20.500.12854/98947 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7000 https://mdpi.com/books/pdfview/book/7000 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6961-1 10.3390/books978-3-0365-6961-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036569604 9783036569611 500 Basel open access |
| spellingShingle | near infrared photoimmunotherapy monoclonal antibodies CD44 interleukin-15 cancer antigen processing and presentation cancer immunotherapy cross-priming immunogenicity major histocompatibility complex T lymphocyte tumor-infiltrating lymphocytes tumor microenvironment tumor-specific antigen pancreatic tumor NK cell immunosurveillance NKG2D histon (de)acetylation immunotherapy PD-1 microenvironment CAR T cells immune checkpoint inhibitors cervical cancer immune checkpoint inhibitor pembrolizumab recurrence pattern-recognition receptors toll-like receptors intratumoural tumour microenvironment NKG2D ligands NKG2D receptor NK cells immune evasion convergent evolution viruses glioblastoma model animal model preclinical murine immune response GBM newcastle disease virus modulated electrohyperthermia dendritic cell vaccination clinical trial individualized multimodal immunotherapy CAR-T cell therapy CD19 clinical trials CRS toxicity immunocyte membrane-coated nanoparticles biomimicry macrophage T-cell natural killer dendritic cell IL-12 family cytokines anti-tumor immunity STAT B cell T cell antibody therapy immuno-oncology CD3-bispecific antibody T-cell engager solid tumors on-target off-tumor toxicity T-cell co-stimulation tumor-associated antigens chimeric antigen receptor immune cell endodomain combination therapy TNFα adoptive cell therapy monoclonal antibody radiotherapy local ablation therapies checkpoint inhibitors chemotherapy protein kinase inhibitors oncolytic virus anti-cancer therapies T cell receptor chimeric antigen receptor (CAR) T cell (CAR-T) signal transduction CD8 coreceptor signaling kinetics oligomerization TAM receptors Axl MerTK small molecule inhibitors CAR T cell therapy T cell metabolism mitochondria memory T cell metabolic reprogramming adipose tissue-derived stem cells (ADSCs) mesenchymal stem cells myxoma virus oncolytic virotherapy pancreatic ductal adenocarcinoma Flt3 Flt3L dendritic cells HER2-positive breast cancer immune checkpoint blockade immune checkpoint molecules PD-1/PD-L1 melanoma tumour antigens Ropporin-1 ROPN1 Ropporin-1B ROPN1B nonreplicating adenovirus vector gene therapy routes of delivery virus coated with cancer cell membrane adoptive cell transfer targeted therapy cell cycle n/a thema EDItEUR::M Medicine and Nursing Challenges and Opportunities for Effective Cancer Immunotherapies |
| title | Challenges and Opportunities for Effective Cancer Immunotherapies |
| title_full | Challenges and Opportunities for Effective Cancer Immunotherapies |
| title_fullStr | Challenges and Opportunities for Effective Cancer Immunotherapies |
| title_full_unstemmed | Challenges and Opportunities for Effective Cancer Immunotherapies |
| title_short | Challenges and Opportunities for Effective Cancer Immunotherapies |
| title_sort | challenges and opportunities for effective cancer immunotherapies |
| topic | near infrared photoimmunotherapy monoclonal antibodies CD44 interleukin-15 cancer antigen processing and presentation cancer immunotherapy cross-priming immunogenicity major histocompatibility complex T lymphocyte tumor-infiltrating lymphocytes tumor microenvironment tumor-specific antigen pancreatic tumor NK cell immunosurveillance NKG2D histon (de)acetylation immunotherapy PD-1 microenvironment CAR T cells immune checkpoint inhibitors cervical cancer immune checkpoint inhibitor pembrolizumab recurrence pattern-recognition receptors toll-like receptors intratumoural tumour microenvironment NKG2D ligands NKG2D receptor NK cells immune evasion convergent evolution viruses glioblastoma model animal model preclinical murine immune response GBM newcastle disease virus modulated electrohyperthermia dendritic cell vaccination clinical trial individualized multimodal immunotherapy CAR-T cell therapy CD19 clinical trials CRS toxicity immunocyte membrane-coated nanoparticles biomimicry macrophage T-cell natural killer dendritic cell IL-12 family cytokines anti-tumor immunity STAT B cell T cell antibody therapy immuno-oncology CD3-bispecific antibody T-cell engager solid tumors on-target off-tumor toxicity T-cell co-stimulation tumor-associated antigens chimeric antigen receptor immune cell endodomain combination therapy TNFα adoptive cell therapy monoclonal antibody radiotherapy local ablation therapies checkpoint inhibitors chemotherapy protein kinase inhibitors oncolytic virus anti-cancer therapies T cell receptor chimeric antigen receptor (CAR) T cell (CAR-T) signal transduction CD8 coreceptor signaling kinetics oligomerization TAM receptors Axl MerTK small molecule inhibitors CAR T cell therapy T cell metabolism mitochondria memory T cell metabolic reprogramming adipose tissue-derived stem cells (ADSCs) mesenchymal stem cells myxoma virus oncolytic virotherapy pancreatic ductal adenocarcinoma Flt3 Flt3L dendritic cells HER2-positive breast cancer immune checkpoint blockade immune checkpoint molecules PD-1/PD-L1 melanoma tumour antigens Ropporin-1 ROPN1 Ropporin-1B ROPN1B nonreplicating adenovirus vector gene therapy routes of delivery virus coated with cancer cell membrane adoptive cell transfer targeted therapy cell cycle n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | near infrared photoimmunotherapy monoclonal antibodies CD44 interleukin-15 cancer antigen processing and presentation cancer immunotherapy cross-priming immunogenicity major histocompatibility complex T lymphocyte tumor-infiltrating lymphocytes tumor microenvironment tumor-specific antigen pancreatic tumor NK cell immunosurveillance NKG2D histon (de)acetylation immunotherapy PD-1 microenvironment CAR T cells immune checkpoint inhibitors cervical cancer immune checkpoint inhibitor pembrolizumab recurrence pattern-recognition receptors toll-like receptors intratumoural tumour microenvironment NKG2D ligands NKG2D receptor NK cells immune evasion convergent evolution viruses glioblastoma model animal model preclinical murine immune response GBM newcastle disease virus modulated electrohyperthermia dendritic cell vaccination clinical trial individualized multimodal immunotherapy CAR-T cell therapy CD19 clinical trials CRS toxicity immunocyte membrane-coated nanoparticles biomimicry macrophage T-cell natural killer dendritic cell IL-12 family cytokines anti-tumor immunity STAT B cell T cell antibody therapy immuno-oncology CD3-bispecific antibody T-cell engager solid tumors on-target off-tumor toxicity T-cell co-stimulation tumor-associated antigens chimeric antigen receptor immune cell endodomain combination therapy TNFα adoptive cell therapy monoclonal antibody radiotherapy local ablation therapies checkpoint inhibitors chemotherapy protein kinase inhibitors oncolytic virus anti-cancer therapies T cell receptor chimeric antigen receptor (CAR) T cell (CAR-T) signal transduction CD8 coreceptor signaling kinetics oligomerization TAM receptors Axl MerTK small molecule inhibitors CAR T cell therapy T cell metabolism mitochondria memory T cell metabolic reprogramming adipose tissue-derived stem cells (ADSCs) mesenchymal stem cells myxoma virus oncolytic virotherapy pancreatic ductal adenocarcinoma Flt3 Flt3L dendritic cells HER2-positive breast cancer immune checkpoint blockade immune checkpoint molecules PD-1/PD-L1 melanoma tumour antigens Ropporin-1 ROPN1 Ropporin-1B ROPN1B nonreplicating adenovirus vector gene therapy routes of delivery virus coated with cancer cell membrane adoptive cell transfer targeted therapy cell cycle n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230405_9783036569604_226 |