Molecular Mechanisms of Steroid Hormone Biosynthesis and Action
Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by ex...
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| Format: | Online |
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online Access: | ONIX_20230405_9783036570037_234 |
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| collection | Directory of Open Access Books |
| description | Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones. |
| format | Online |
| id | doab-20.500.12854ir-98955 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-989552024-03-31T13:08:23Z Molecular Mechanisms of Steroid Hormone Biosynthesis and Action Tremblay, Jacques J. steroidogenesis testis transcription testosterone Leydig cell GATA cholesterol cholesterol transport steroidogenic acute regulatory protein sterol carrier protein 2 sterol carrier protein-x MnHR4 20-hydroxyecdysone (20E) Macrobrachium nipponense molt RNA interference Leydig cells star AMPK phosphoproteomics proteomics activator protein 1 CREB CEBPB Steroidogenesis signaling cascade Nuclear receptors bZIP factors MEF2 factors GATA4 CAMKI PKA ERK1/2 Hippo signaling Lats1/2 fetal Leydig cells Sertoli cells transgenic mouse model ovary cow Hippo follicle deviation or divergence yes-associated protein 1 CTGF CYR61 ANKRD1 transgenic mice adrenal cortex development maintenance glucocorticoid receptor androgens leydig cells AAV9 insulin-like 3 transcription factors linker-scanning mutagenesis DNA–protein interactions bile acids TGR5 cholesterol esters LH LH-receptor spermatogenesis thrombospondin-2 NR5A1 enhancer pituitary gonadotrope luteinizing hormone follicle-stimulating hormone 11-oxygenated androgens steroid hormones LC-MS/MS method validation adrenocortical carcinoma histone deacetylase inhibitor cell differentiation gene expression adrenal gland inner cortex X-zone DHCR24 seladin-1 endocrine disruptors EDC mixtures in utero exposures transcriptome analysis testicular function aldo-keto reductase bile acid deficiency congenital adrenal hyperplasia hydroxysteroid dehydrogenase prostate cancer single nucleotide polymorphism structure-function steroid reductase pseudohermaphroditism thema EDItEUR::M Medicine and Nursing Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones. 2023-04-05T13:00:51Z 2023-04-05T13:00:51Z 2023 book ONIX_20230405_9783036570037_234 9783036570037 9783036570020 https://directory.doabooks.org/handle/20.500.12854/98955 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7008 https://mdpi.com/books/pdfview/book/7008 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7002-0 10.3390/books978-3-0365-7002-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036570037 9783036570020 360 Basel open access |
| spellingShingle | steroidogenesis testis transcription testosterone Leydig cell GATA cholesterol cholesterol transport steroidogenic acute regulatory protein sterol carrier protein 2 sterol carrier protein-x MnHR4 20-hydroxyecdysone (20E) Macrobrachium nipponense molt RNA interference Leydig cells star AMPK phosphoproteomics proteomics activator protein 1 CREB CEBPB Steroidogenesis signaling cascade Nuclear receptors bZIP factors MEF2 factors GATA4 CAMKI PKA ERK1/2 Hippo signaling Lats1/2 fetal Leydig cells Sertoli cells transgenic mouse model ovary cow Hippo follicle deviation or divergence yes-associated protein 1 CTGF CYR61 ANKRD1 transgenic mice adrenal cortex development maintenance glucocorticoid receptor androgens leydig cells AAV9 insulin-like 3 transcription factors linker-scanning mutagenesis DNA–protein interactions bile acids TGR5 cholesterol esters LH LH-receptor spermatogenesis thrombospondin-2 NR5A1 enhancer pituitary gonadotrope luteinizing hormone follicle-stimulating hormone 11-oxygenated androgens steroid hormones LC-MS/MS method validation adrenocortical carcinoma histone deacetylase inhibitor cell differentiation gene expression adrenal gland inner cortex X-zone DHCR24 seladin-1 endocrine disruptors EDC mixtures in utero exposures transcriptome analysis testicular function aldo-keto reductase bile acid deficiency congenital adrenal hyperplasia hydroxysteroid dehydrogenase prostate cancer single nucleotide polymorphism structure-function steroid reductase pseudohermaphroditism thema EDItEUR::M Medicine and Nursing Molecular Mechanisms of Steroid Hormone Biosynthesis and Action |
| title | Molecular Mechanisms of Steroid Hormone Biosynthesis and Action |
| title_full | Molecular Mechanisms of Steroid Hormone Biosynthesis and Action |
| title_fullStr | Molecular Mechanisms of Steroid Hormone Biosynthesis and Action |
| title_full_unstemmed | Molecular Mechanisms of Steroid Hormone Biosynthesis and Action |
| title_short | Molecular Mechanisms of Steroid Hormone Biosynthesis and Action |
| title_sort | molecular mechanisms of steroid hormone biosynthesis and action |
| topic | steroidogenesis testis transcription testosterone Leydig cell GATA cholesterol cholesterol transport steroidogenic acute regulatory protein sterol carrier protein 2 sterol carrier protein-x MnHR4 20-hydroxyecdysone (20E) Macrobrachium nipponense molt RNA interference Leydig cells star AMPK phosphoproteomics proteomics activator protein 1 CREB CEBPB Steroidogenesis signaling cascade Nuclear receptors bZIP factors MEF2 factors GATA4 CAMKI PKA ERK1/2 Hippo signaling Lats1/2 fetal Leydig cells Sertoli cells transgenic mouse model ovary cow Hippo follicle deviation or divergence yes-associated protein 1 CTGF CYR61 ANKRD1 transgenic mice adrenal cortex development maintenance glucocorticoid receptor androgens leydig cells AAV9 insulin-like 3 transcription factors linker-scanning mutagenesis DNA–protein interactions bile acids TGR5 cholesterol esters LH LH-receptor spermatogenesis thrombospondin-2 NR5A1 enhancer pituitary gonadotrope luteinizing hormone follicle-stimulating hormone 11-oxygenated androgens steroid hormones LC-MS/MS method validation adrenocortical carcinoma histone deacetylase inhibitor cell differentiation gene expression adrenal gland inner cortex X-zone DHCR24 seladin-1 endocrine disruptors EDC mixtures in utero exposures transcriptome analysis testicular function aldo-keto reductase bile acid deficiency congenital adrenal hyperplasia hydroxysteroid dehydrogenase prostate cancer single nucleotide polymorphism structure-function steroid reductase pseudohermaphroditism thema EDItEUR::M Medicine and Nursing |
| topic_facet | steroidogenesis testis transcription testosterone Leydig cell GATA cholesterol cholesterol transport steroidogenic acute regulatory protein sterol carrier protein 2 sterol carrier protein-x MnHR4 20-hydroxyecdysone (20E) Macrobrachium nipponense molt RNA interference Leydig cells star AMPK phosphoproteomics proteomics activator protein 1 CREB CEBPB Steroidogenesis signaling cascade Nuclear receptors bZIP factors MEF2 factors GATA4 CAMKI PKA ERK1/2 Hippo signaling Lats1/2 fetal Leydig cells Sertoli cells transgenic mouse model ovary cow Hippo follicle deviation or divergence yes-associated protein 1 CTGF CYR61 ANKRD1 transgenic mice adrenal cortex development maintenance glucocorticoid receptor androgens leydig cells AAV9 insulin-like 3 transcription factors linker-scanning mutagenesis DNA–protein interactions bile acids TGR5 cholesterol esters LH LH-receptor spermatogenesis thrombospondin-2 NR5A1 enhancer pituitary gonadotrope luteinizing hormone follicle-stimulating hormone 11-oxygenated androgens steroid hormones LC-MS/MS method validation adrenocortical carcinoma histone deacetylase inhibitor cell differentiation gene expression adrenal gland inner cortex X-zone DHCR24 seladin-1 endocrine disruptors EDC mixtures in utero exposures transcriptome analysis testicular function aldo-keto reductase bile acid deficiency congenital adrenal hyperplasia hydroxysteroid dehydrogenase prostate cancer single nucleotide polymorphism structure-function steroid reductase pseudohermaphroditism thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230405_9783036570037_234 |