Addressing New Therapeutic Strategies Using Models
A disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, establishing the pathophysiology of a disease, and testing pote...
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| Formato: | Online |
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| Idioma: | inglês |
| Publicado em: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Acesso em linha: | ONIX_20230405_9783036570839_239 |
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| collection | Directory of Open Access Books |
| description | A disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, establishing the pathophysiology of a disease, and testing potential therapeutic approaches.Models have been long used to study several diseases, including cardiovascular, oncologic, metabolic, infectious, and neurological diseases, among others. Animals or cells displaying pathological processes observed in human or animal diseases have been used as models. Moreover, mathematical models are also of great importance to disease modeling. Animal models offer the unique opportunity to investigate the function of genes and pathways and the in vivo effects of drugs, bridging the gap between basic science and the treatment of diseases. The selection of a suitable model system is a crucial step in research design. For disease modeling to be meaningful, a relevant cellular or genetic phenotype must be observed. Without the use of models, both research and clinical practice worldwide would be vastly different today.This Special Issue aimed to publish original research works or reviews with models of disease, highlighting their importance to search for new therapeutic strategies. |
| format | Online |
| id | doab-20.500.12854ir-98960 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-989602024-03-28T03:33:45Z Addressing New Therapeutic Strategies Using Models Faustino, Ana Oliveira, Paula A. spontaneous models induced models genetically engineered models acute kidney injury biomarkers coagulation ischemia-reperfusion injury shock newborn lamb multiple intestinal loop model 3R Cryptosporidium parvum yeast cell wall fractions fatty liver disease glucose imipramine insulin obesity renal impairment retinal injury xenograft ectopic orthotopic hIBC cIMC whole-body ischemia cardiopulmonary resuscitation drug-induced hypothermia spinal motor neuron inflammation paraplegia virucidal drugs IBV chickens Coronaviridae silver nanoparticles artificial ribonuclease monoglyceride lauryl acid spinal cord hemisection Macaca radiata predegenerated nerve transplantation locomotor recovery Cornu Ammonis 1 glutaminergic synapse memory function oligodendrocyte pyramidal cells animal model trichotillomania hair-pulling body-focused repetitive disorder transitional cell carcinoma urothelial carcinoma histology therapeutic marker prognosis mandibular growth mandibular posterior displacement mandibular length condylar growth rat class III malocclusion orthodontic treatment antebrachial growth deformity dog osteotomy patient-specific instrumentation 3-D n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences A disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, establishing the pathophysiology of a disease, and testing potential therapeutic approaches.Models have been long used to study several diseases, including cardiovascular, oncologic, metabolic, infectious, and neurological diseases, among others. Animals or cells displaying pathological processes observed in human or animal diseases have been used as models. Moreover, mathematical models are also of great importance to disease modeling. Animal models offer the unique opportunity to investigate the function of genes and pathways and the in vivo effects of drugs, bridging the gap between basic science and the treatment of diseases. The selection of a suitable model system is a crucial step in research design. For disease modeling to be meaningful, a relevant cellular or genetic phenotype must be observed. Without the use of models, both research and clinical practice worldwide would be vastly different today.This Special Issue aimed to publish original research works or reviews with models of disease, highlighting their importance to search for new therapeutic strategies. 2023-04-05T13:01:06Z 2023-04-05T13:01:06Z 2023 book ONIX_20230405_9783036570839_239 9783036570839 9783036570822 https://directory.doabooks.org/handle/20.500.12854/98960 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7013 https://mdpi.com/books/pdfview/book/7013 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7082-2 10.3390/books978-3-0365-7082-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036570839 9783036570822 246 Basel open access |
| spellingShingle | spontaneous models induced models genetically engineered models acute kidney injury biomarkers coagulation ischemia-reperfusion injury shock newborn lamb multiple intestinal loop model 3R Cryptosporidium parvum yeast cell wall fractions fatty liver disease glucose imipramine insulin obesity renal impairment retinal injury xenograft ectopic orthotopic hIBC cIMC whole-body ischemia cardiopulmonary resuscitation drug-induced hypothermia spinal motor neuron inflammation paraplegia virucidal drugs IBV chickens Coronaviridae silver nanoparticles artificial ribonuclease monoglyceride lauryl acid spinal cord hemisection Macaca radiata predegenerated nerve transplantation locomotor recovery Cornu Ammonis 1 glutaminergic synapse memory function oligodendrocyte pyramidal cells animal model trichotillomania hair-pulling body-focused repetitive disorder transitional cell carcinoma urothelial carcinoma histology therapeutic marker prognosis mandibular growth mandibular posterior displacement mandibular length condylar growth rat class III malocclusion orthodontic treatment antebrachial growth deformity dog osteotomy patient-specific instrumentation 3-D n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Addressing New Therapeutic Strategies Using Models |
| title | Addressing New Therapeutic Strategies Using Models |
| title_full | Addressing New Therapeutic Strategies Using Models |
| title_fullStr | Addressing New Therapeutic Strategies Using Models |
| title_full_unstemmed | Addressing New Therapeutic Strategies Using Models |
| title_short | Addressing New Therapeutic Strategies Using Models |
| title_sort | addressing new therapeutic strategies using models |
| topic | spontaneous models induced models genetically engineered models acute kidney injury biomarkers coagulation ischemia-reperfusion injury shock newborn lamb multiple intestinal loop model 3R Cryptosporidium parvum yeast cell wall fractions fatty liver disease glucose imipramine insulin obesity renal impairment retinal injury xenograft ectopic orthotopic hIBC cIMC whole-body ischemia cardiopulmonary resuscitation drug-induced hypothermia spinal motor neuron inflammation paraplegia virucidal drugs IBV chickens Coronaviridae silver nanoparticles artificial ribonuclease monoglyceride lauryl acid spinal cord hemisection Macaca radiata predegenerated nerve transplantation locomotor recovery Cornu Ammonis 1 glutaminergic synapse memory function oligodendrocyte pyramidal cells animal model trichotillomania hair-pulling body-focused repetitive disorder transitional cell carcinoma urothelial carcinoma histology therapeutic marker prognosis mandibular growth mandibular posterior displacement mandibular length condylar growth rat class III malocclusion orthodontic treatment antebrachial growth deformity dog osteotomy patient-specific instrumentation 3-D n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | spontaneous models induced models genetically engineered models acute kidney injury biomarkers coagulation ischemia-reperfusion injury shock newborn lamb multiple intestinal loop model 3R Cryptosporidium parvum yeast cell wall fractions fatty liver disease glucose imipramine insulin obesity renal impairment retinal injury xenograft ectopic orthotopic hIBC cIMC whole-body ischemia cardiopulmonary resuscitation drug-induced hypothermia spinal motor neuron inflammation paraplegia virucidal drugs IBV chickens Coronaviridae silver nanoparticles artificial ribonuclease monoglyceride lauryl acid spinal cord hemisection Macaca radiata predegenerated nerve transplantation locomotor recovery Cornu Ammonis 1 glutaminergic synapse memory function oligodendrocyte pyramidal cells animal model trichotillomania hair-pulling body-focused repetitive disorder transitional cell carcinoma urothelial carcinoma histology therapeutic marker prognosis mandibular growth mandibular posterior displacement mandibular length condylar growth rat class III malocclusion orthodontic treatment antebrachial growth deformity dog osteotomy patient-specific instrumentation 3-D n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230405_9783036570839_239 |