Model-Informed Precision Dosing
Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD...
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| Formato: | Online |
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| Idioma: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Subjects: | |
| Acceso en liña: | ONIX_20230405_9783036568966_288 |
| Tags: |
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| _version_ | 1869525405688397824 |
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| collection | Directory of Open Access Books |
| description | Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs. |
| format | Online |
| id | doab-20.500.12854ir-99009 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-990092024-03-31T13:10:25Z Model-Informed Precision Dosing Pérez-Blanco, Jonás Samuel Lanao, José Martínez model-informed precision dosing (MIPD) efficacy PKPD indexes pharmacokinetics pharmacodynamics PKPD modeling and simulation dosing algorithms nomograms thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs. 2023-04-05T13:04:11Z 2023-04-05T13:04:11Z 2023 book ONIX_20230405_9783036568966_288 9783036568966 9783036568973 https://directory.doabooks.org/handle/20.500.12854/99009 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7075 https://mdpi.com/books/pdfview/book/7075 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6897-3 10.3390/books978-3-0365-6897-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036568966 9783036568973 320 Basel open access |
| spellingShingle | model-informed precision dosing (MIPD) efficacy PKPD indexes pharmacokinetics pharmacodynamics PKPD modeling and simulation dosing algorithms nomograms thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Model-Informed Precision Dosing |
| title | Model-Informed Precision Dosing |
| title_full | Model-Informed Precision Dosing |
| title_fullStr | Model-Informed Precision Dosing |
| title_full_unstemmed | Model-Informed Precision Dosing |
| title_short | Model-Informed Precision Dosing |
| title_sort | model informed precision dosing |
| topic | model-informed precision dosing (MIPD) efficacy PKPD indexes pharmacokinetics pharmacodynamics PKPD modeling and simulation dosing algorithms nomograms thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | model-informed precision dosing (MIPD) efficacy PKPD indexes pharmacokinetics pharmacodynamics PKPD modeling and simulation dosing algorithms nomograms thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20230405_9783036568966_288 |