Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities
At the molecular level, the activation of growth factor receptors (GFRs) induces a mitogenic response and maintains cancer cell growth. The majority of malignant diseases are related to aberrant intra- and intercellular communication, associated with the GFR-mediated pathways. Moreover, the evasion...
Wedi'i Gadw mewn:
| Fformat: | Online |
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| Iaith: | Saesneg |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Pynciau: | |
| Mynediad Ar-lein: | ONIX_20230511_9783036573373_107 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869528294121013248 |
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| collection | Directory of Open Access Books |
| description | At the molecular level, the activation of growth factor receptors (GFRs) induces a mitogenic response and maintains cancer cell growth. The majority of malignant diseases are related to aberrant intra- and intercellular communication, associated with the GFR-mediated pathways. Moreover, the evasion of apoptotic signals and the requirement of angiogenesis were also found to be of fundamental importance for tumor progression and metastasis. In this context, a high expression of GFRs aids blood vessel formation, cell migration, and the inhibition of apoptosis. GFR-directed therapy that would theoretically selectively kill malignant cells and reduce the toxicity associated with nonselective conventional chemotherapy may be a promising treatment for cancer. Many intracellular proteins involved in GFR signal transduction can also function as oncogenes. Mutations affecting key proteins in the RAS/MAPK and PI3K/AKT pathways are known to be crucial in maintaining the malignancy of different types of cancers. This information has guided the development of compounds designed to target one or more of these pathways in cancer cells. Even though there have been important advances in our understanding of GFRs and their signaling, certain essential information is still lacking, and these membrane receptors are still being laboriously studied by several research groups, to find therapeutic solutions to unmet medical needs. |
| format | Online |
| id | doab-20.500.12854ir-100090 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1000902024-03-31T13:10:44Z Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities Dricu, Anica oral cancer autophagy PI3K/AKT/mTOR signaling pathway gastric cancer HER3 heregulin MET SATB1 breast cancer estrogen receptor-positive HER2 PI3K/AKT/mTOR pathway endocrine resistance glioma pathways EGFR clinical trials gastric carcinoma norepinephrine transporter plasma free metanephrines and normetanephrines coronavirus pandemic tyrosine kinase receptor signaling pathway ELTD1 biomarker angiogenesis cancer colorectal cancer growth factors PI3K/AKT/mTOR MAPK growth factor inhibitors nivolumab interleukin 10 T cells cytokines STAT3 pathway AKT serine–threonine kinase pathway MAP kinase pathway single-cell RNA-seq primary cerebral tumors cancer stem-like cells human neural stem cells human neural progenitors neurogenesis gliogenesis n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology At the molecular level, the activation of growth factor receptors (GFRs) induces a mitogenic response and maintains cancer cell growth. The majority of malignant diseases are related to aberrant intra- and intercellular communication, associated with the GFR-mediated pathways. Moreover, the evasion of apoptotic signals and the requirement of angiogenesis were also found to be of fundamental importance for tumor progression and metastasis. In this context, a high expression of GFRs aids blood vessel formation, cell migration, and the inhibition of apoptosis. GFR-directed therapy that would theoretically selectively kill malignant cells and reduce the toxicity associated with nonselective conventional chemotherapy may be a promising treatment for cancer. Many intracellular proteins involved in GFR signal transduction can also function as oncogenes. Mutations affecting key proteins in the RAS/MAPK and PI3K/AKT pathways are known to be crucial in maintaining the malignancy of different types of cancers. This information has guided the development of compounds designed to target one or more of these pathways in cancer cells. Even though there have been important advances in our understanding of GFRs and their signaling, certain essential information is still lacking, and these membrane receptors are still being laboriously studied by several research groups, to find therapeutic solutions to unmet medical needs. 2023-05-11T17:20:21Z 2023-05-11T17:20:21Z 2023 book ONIX_20230511_9783036573373_107 9783036573373 9783036573366 https://directory.doabooks.org/handle/20.500.12854/100090 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7183 https://mdpi.com/books/pdfview/book/7183 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7336-6 10.3390/books978-3-0365-7336-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036573373 9783036573366 202 Basel open access |
| spellingShingle | oral cancer autophagy PI3K/AKT/mTOR signaling pathway gastric cancer HER3 heregulin MET SATB1 breast cancer estrogen receptor-positive HER2 PI3K/AKT/mTOR pathway endocrine resistance glioma pathways EGFR clinical trials gastric carcinoma norepinephrine transporter plasma free metanephrines and normetanephrines coronavirus pandemic tyrosine kinase receptor signaling pathway ELTD1 biomarker angiogenesis cancer colorectal cancer growth factors PI3K/AKT/mTOR MAPK growth factor inhibitors nivolumab interleukin 10 T cells cytokines STAT3 pathway AKT serine–threonine kinase pathway MAP kinase pathway single-cell RNA-seq primary cerebral tumors cancer stem-like cells human neural stem cells human neural progenitors neurogenesis gliogenesis n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities |
| title | Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities |
| title_full | Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities |
| title_fullStr | Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities |
| title_full_unstemmed | Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities |
| title_short | Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities |
| title_sort | oncogenic signaling of growth factor receptors in cancer mechanisms and therapeutic opportunities |
| topic | oral cancer autophagy PI3K/AKT/mTOR signaling pathway gastric cancer HER3 heregulin MET SATB1 breast cancer estrogen receptor-positive HER2 PI3K/AKT/mTOR pathway endocrine resistance glioma pathways EGFR clinical trials gastric carcinoma norepinephrine transporter plasma free metanephrines and normetanephrines coronavirus pandemic tyrosine kinase receptor signaling pathway ELTD1 biomarker angiogenesis cancer colorectal cancer growth factors PI3K/AKT/mTOR MAPK growth factor inhibitors nivolumab interleukin 10 T cells cytokines STAT3 pathway AKT serine–threonine kinase pathway MAP kinase pathway single-cell RNA-seq primary cerebral tumors cancer stem-like cells human neural stem cells human neural progenitors neurogenesis gliogenesis n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | oral cancer autophagy PI3K/AKT/mTOR signaling pathway gastric cancer HER3 heregulin MET SATB1 breast cancer estrogen receptor-positive HER2 PI3K/AKT/mTOR pathway endocrine resistance glioma pathways EGFR clinical trials gastric carcinoma norepinephrine transporter plasma free metanephrines and normetanephrines coronavirus pandemic tyrosine kinase receptor signaling pathway ELTD1 biomarker angiogenesis cancer colorectal cancer growth factors PI3K/AKT/mTOR MAPK growth factor inhibitors nivolumab interleukin 10 T cells cytokines STAT3 pathway AKT serine–threonine kinase pathway MAP kinase pathway single-cell RNA-seq primary cerebral tumors cancer stem-like cells human neural stem cells human neural progenitors neurogenesis gliogenesis n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20230511_9783036573373_107 |