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PI3K/AKT/mTOR Signaling Network in Human Health and Diseases

In recent years, researchers have shown a special interest in the role of signaling pathways as disease molecular targets and capitalized on such pathways to derive natural products, biologics, and synthetic scaffold-based prevention and treatments. These can lead to naturally available, efficacious...

Ausführliche Beschreibung

Gespeichert in:
Format: Online
Sprache:Englisch
Veröffentlicht: MDPI - Multidisciplinary Digital Publishing Institute 2025
Schlagworte:
hepatocellular cancer
HCC
LIHC
PDK1
PI3K/AKT/mTOR pathway
BX795
selective inhibitor
radiotherapy
radioresistance
combination therapy
stemness
DNA damage
galectin-1
upper urinary urothelial carcinoma
epithelial–mesenchymal transition
survival
phosphoinositide 3-kinases
focal adhesion kinase
mammalian target of rapamycin
ascorbic acid
oxidative stress
apoptosis
autophagic flux blockage
PI3K/Akt
corneal endothelial cells
PIK3CA
colorectal cancer
EGFR pathway
tumor heterogeneity
RSK
mTORC2
p90 ribosomal s6 kinase
nutrients
AGC kinases
MAPK/ERK
CCTβ
CCT/TRiC
chaperonin
starvation
metabolism
TFEB agonists
autophagy
lysosome
rapamycin
resveratrol
dihydroartemisinin
rhabdomyosarcoma
mTOR
AMPK
PTEN
raptor
muscle protein synthesis
GSI
AKT
SEA complex
GATOR complex
mTORC1 pathway
amino acid signaling
cancer
epilepsy
neurological disorders
JC polyomavirus
PML
astrocytes
SVGA cells
primary cells
PI3K
wortmannin
PI3K/Akt pathway
myocardial infarction
heart failure
left ventricular remodeling
diabetes
necroptosis
ferroptosis
pyroptosis
fibrosis
extracellular vesicles
PI3K/Akt/mTOR pathway
bone marrow mesenchymal stem cells
bone microvascular endothelial cells
breast cancer
AKT1
RNA-sequencing
transcriptome
emerging functions and targets
cancer therapeutics
psoriasis
inflammation
mTORC1
tuberous sclerosis complex
cytokines
cell penetrating peptide
cellular signaling
kinase
protein kinase B (AKT1)
phosphoinositide-dependent kinase (PDK1)
recombinant protein
trans-activator of transcription (TAT)
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat
Online-Zugang:ONIX_20250220_9783725827749_425
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