PI3K/AKT/mTOR Signaling Network in Human Health and Diseases
In recent years, researchers have shown a special interest in the role of signaling pathways as disease molecular targets and capitalized on such pathways to derive natural products, biologics, and synthetic scaffold-based prevention and treatments. These can lead to naturally available, efficacious...
محفوظ في:
| التنسيق: | Online |
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| اللغة: | الإنجليزية |
| منشور في: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | ONIX_20250220_9783725827749_425 |
| الوسوم: |
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| _version_ | 1869514435829170176 |
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| collection | Directory of Open Access Books |
| description | In recent years, researchers have shown a special interest in the role of signaling pathways as disease molecular targets and capitalized on such pathways to derive natural products, biologics, and synthetic scaffold-based prevention and treatments. These can lead to naturally available, efficacious, low-cost, and minimally toxic long-term therapies for human diseases. This Special Issue of Cells comprises an array of literature reviews, original communications, and studies on the roles of the PI3K/AKT/mTOR and associated pathways in a diversity of pathways using in vitro cell-based assays and preclinical animal models. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of human disorders, the wealth of information published in this Special Issue can act as a springboard for the identification of novel disease targets and the development of new preventive and therapeutic modalities for the management of human diseases. |
| format | Online |
| id | doab-20.500.12854ir-153061 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1530612025-02-20T13:30:02Z PI3K/AKT/mTOR Signaling Network in Human Health and Diseases Chamcheu, Jean Christopher Bürger, Claudia Huang, Shile hepatocellular cancer HCC LIHC PDK1 PI3K/AKT/mTOR pathway BX795 selective inhibitor radiotherapy radioresistance combination therapy stemness DNA damage galectin-1 upper urinary urothelial carcinoma epithelial–mesenchymal transition survival phosphoinositide 3-kinases focal adhesion kinase mammalian target of rapamycin ascorbic acid oxidative stress apoptosis autophagic flux blockage PI3K/Akt corneal endothelial cells PIK3CA colorectal cancer EGFR pathway tumor heterogeneity RSK mTORC2 p90 ribosomal s6 kinase nutrients AGC kinases MAPK/ERK CCTβ CCT/TRiC chaperonin starvation metabolism TFEB agonists autophagy lysosome rapamycin resveratrol dihydroartemisinin rhabdomyosarcoma mTOR AMPK PTEN raptor muscle protein synthesis GSI AKT SEA complex GATOR complex mTORC1 pathway amino acid signaling cancer epilepsy neurological disorders JC polyomavirus PML astrocytes SVGA cells primary cells PI3K wortmannin PI3K/Akt pathway myocardial infarction heart failure left ventricular remodeling diabetes necroptosis ferroptosis pyroptosis fibrosis extracellular vesicles PI3K/Akt/mTOR pathway bone marrow mesenchymal stem cells bone microvascular endothelial cells breast cancer AKT1 RNA-sequencing transcriptome emerging functions and targets cancer therapeutics psoriasis inflammation mTORC1 tuberous sclerosis complex cytokines cell penetrating peptide cellular signaling kinase protein kinase B (AKT1) phosphoinositide-dependent kinase (PDK1) recombinant protein trans-activator of transcription (TAT) n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat In recent years, researchers have shown a special interest in the role of signaling pathways as disease molecular targets and capitalized on such pathways to derive natural products, biologics, and synthetic scaffold-based prevention and treatments. These can lead to naturally available, efficacious, low-cost, and minimally toxic long-term therapies for human diseases. This Special Issue of Cells comprises an array of literature reviews, original communications, and studies on the roles of the PI3K/AKT/mTOR and associated pathways in a diversity of pathways using in vitro cell-based assays and preclinical animal models. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of human disorders, the wealth of information published in this Special Issue can act as a springboard for the identification of novel disease targets and the development of new preventive and therapeutic modalities for the management of human diseases. 2025-02-20T13:29:59Z 2025-02-20T13:29:59Z 2025 book ONIX_20250220_9783725827749_425 9783725827749 9783725827732 https://directory.doabooks.org/handle/20.500.12854/153061 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10392 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2773-2 10.3390/books978-3-7258-2773-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725827749 9783725827732 320 Basel open access |
| spellingShingle | hepatocellular cancer HCC LIHC PDK1 PI3K/AKT/mTOR pathway BX795 selective inhibitor radiotherapy radioresistance combination therapy stemness DNA damage galectin-1 upper urinary urothelial carcinoma epithelial–mesenchymal transition survival phosphoinositide 3-kinases focal adhesion kinase mammalian target of rapamycin ascorbic acid oxidative stress apoptosis autophagic flux blockage PI3K/Akt corneal endothelial cells PIK3CA colorectal cancer EGFR pathway tumor heterogeneity RSK mTORC2 p90 ribosomal s6 kinase nutrients AGC kinases MAPK/ERK CCTβ CCT/TRiC chaperonin starvation metabolism TFEB agonists autophagy lysosome rapamycin resveratrol dihydroartemisinin rhabdomyosarcoma mTOR AMPK PTEN raptor muscle protein synthesis GSI AKT SEA complex GATOR complex mTORC1 pathway amino acid signaling cancer epilepsy neurological disorders JC polyomavirus PML astrocytes SVGA cells primary cells PI3K wortmannin PI3K/Akt pathway myocardial infarction heart failure left ventricular remodeling diabetes necroptosis ferroptosis pyroptosis fibrosis extracellular vesicles PI3K/Akt/mTOR pathway bone marrow mesenchymal stem cells bone microvascular endothelial cells breast cancer AKT1 RNA-sequencing transcriptome emerging functions and targets cancer therapeutics psoriasis inflammation mTORC1 tuberous sclerosis complex cytokines cell penetrating peptide cellular signaling kinase protein kinase B (AKT1) phosphoinositide-dependent kinase (PDK1) recombinant protein trans-activator of transcription (TAT) n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat PI3K/AKT/mTOR Signaling Network in Human Health and Diseases |
| title | PI3K/AKT/mTOR Signaling Network in Human Health and Diseases |
| title_full | PI3K/AKT/mTOR Signaling Network in Human Health and Diseases |
| title_fullStr | PI3K/AKT/mTOR Signaling Network in Human Health and Diseases |
| title_full_unstemmed | PI3K/AKT/mTOR Signaling Network in Human Health and Diseases |
| title_short | PI3K/AKT/mTOR Signaling Network in Human Health and Diseases |
| title_sort | pi3k akt mtor signaling network in human health and diseases |
| topic | hepatocellular cancer HCC LIHC PDK1 PI3K/AKT/mTOR pathway BX795 selective inhibitor radiotherapy radioresistance combination therapy stemness DNA damage galectin-1 upper urinary urothelial carcinoma epithelial–mesenchymal transition survival phosphoinositide 3-kinases focal adhesion kinase mammalian target of rapamycin ascorbic acid oxidative stress apoptosis autophagic flux blockage PI3K/Akt corneal endothelial cells PIK3CA colorectal cancer EGFR pathway tumor heterogeneity RSK mTORC2 p90 ribosomal s6 kinase nutrients AGC kinases MAPK/ERK CCTβ CCT/TRiC chaperonin starvation metabolism TFEB agonists autophagy lysosome rapamycin resveratrol dihydroartemisinin rhabdomyosarcoma mTOR AMPK PTEN raptor muscle protein synthesis GSI AKT SEA complex GATOR complex mTORC1 pathway amino acid signaling cancer epilepsy neurological disorders JC polyomavirus PML astrocytes SVGA cells primary cells PI3K wortmannin PI3K/Akt pathway myocardial infarction heart failure left ventricular remodeling diabetes necroptosis ferroptosis pyroptosis fibrosis extracellular vesicles PI3K/Akt/mTOR pathway bone marrow mesenchymal stem cells bone microvascular endothelial cells breast cancer AKT1 RNA-sequencing transcriptome emerging functions and targets cancer therapeutics psoriasis inflammation mTORC1 tuberous sclerosis complex cytokines cell penetrating peptide cellular signaling kinase protein kinase B (AKT1) phosphoinositide-dependent kinase (PDK1) recombinant protein trans-activator of transcription (TAT) n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat |
| topic_facet | hepatocellular cancer HCC LIHC PDK1 PI3K/AKT/mTOR pathway BX795 selective inhibitor radiotherapy radioresistance combination therapy stemness DNA damage galectin-1 upper urinary urothelial carcinoma epithelial–mesenchymal transition survival phosphoinositide 3-kinases focal adhesion kinase mammalian target of rapamycin ascorbic acid oxidative stress apoptosis autophagic flux blockage PI3K/Akt corneal endothelial cells PIK3CA colorectal cancer EGFR pathway tumor heterogeneity RSK mTORC2 p90 ribosomal s6 kinase nutrients AGC kinases MAPK/ERK CCTβ CCT/TRiC chaperonin starvation metabolism TFEB agonists autophagy lysosome rapamycin resveratrol dihydroartemisinin rhabdomyosarcoma mTOR AMPK PTEN raptor muscle protein synthesis GSI AKT SEA complex GATOR complex mTORC1 pathway amino acid signaling cancer epilepsy neurological disorders JC polyomavirus PML astrocytes SVGA cells primary cells PI3K wortmannin PI3K/Akt pathway myocardial infarction heart failure left ventricular remodeling diabetes necroptosis ferroptosis pyroptosis fibrosis extracellular vesicles PI3K/Akt/mTOR pathway bone marrow mesenchymal stem cells bone microvascular endothelial cells breast cancer AKT1 RNA-sequencing transcriptome emerging functions and targets cancer therapeutics psoriasis inflammation mTORC1 tuberous sclerosis complex cytokines cell penetrating peptide cellular signaling kinase protein kinase B (AKT1) phosphoinositide-dependent kinase (PDK1) recombinant protein trans-activator of transcription (TAT) n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat |
| url | ONIX_20250220_9783725827749_425 |