PI3K/AKT/mTOR Signaling Network in Human Health and Diseases

In recent years, researchers have shown a special interest in the role of signaling pathways as disease molecular targets and capitalized on such pathways to derive natural products, biologics, and synthetic scaffold-based prevention and treatments. These can lead to naturally available, efficacious...

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Bibliografiske detaljer
Format:	Online
Sprog:	engelsk
Udgivet:	MDPI - Multidisciplinary Digital Publishing Institute 2025
Fag:	hepatocellular cancer HCC LIHC PDK1 PI3K/AKT/mTOR pathway BX795 selective inhibitor radiotherapy radioresistance combination therapy stemness DNA damage galectin-1 upper urinary urothelial carcinoma epithelial–mesenchymal transition survival phosphoinositide 3-kinases focal adhesion kinase mammalian target of rapamycin ascorbic acid oxidative stress apoptosis autophagic flux blockage PI3K/Akt corneal endothelial cells PIK3CA colorectal cancer EGFR pathway tumor heterogeneity RSK mTORC2 p90 ribosomal s6 kinase nutrients AGC kinases MAPK/ERK CCTβ CCT/TRiC chaperonin starvation metabolism TFEB agonists autophagy lysosome rapamycin resveratrol dihydroartemisinin rhabdomyosarcoma mTOR AMPK PTEN raptor muscle protein synthesis GSI AKT SEA complex GATOR complex mTORC1 pathway amino acid signaling cancer epilepsy neurological disorders JC polyomavirus PML astrocytes SVGA cells primary cells PI3K wortmannin PI3K/Akt pathway myocardial infarction heart failure left ventricular remodeling diabetes necroptosis ferroptosis pyroptosis fibrosis extracellular vesicles PI3K/Akt/mTOR pathway bone marrow mesenchymal stem cells bone microvascular endothelial cells breast cancer AKT1 RNA-sequencing transcriptome emerging functions and targets cancer therapeutics psoriasis inflammation mTORC1 tuberous sclerosis complex cytokines cell penetrating peptide cellular signaling kinase protein kinase B (AKT1) phosphoinositide-dependent kinase (PDK1) recombinant protein trans-activator of transcription (TAT) n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat
Online adgang:	ONIX_20250220_9783725827749_425
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PI3K/AKT/mTOR Signaling Network in Human Health and Diseases

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