Radiation Damage in Biomolecules and Cells
The papers collected in this Special Issue deal with the effects of ionizing radiation at molecular and cellular levels, as well as possible applications in medicine and radiation protection. In particular, some works analysed the early stages of the interaction between ionizing radiation and DNA fo...
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| Formatua: | Online |
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| Hizkuntza: | ingelesa |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Sarrera elektronikoa: | ONIX_20230511_9783036574875_144 |
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| _version_ | 1869531598548893696 |
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| collection | Directory of Open Access Books |
| description | The papers collected in this Special Issue deal with the effects of ionizing radiation at molecular and cellular levels, as well as possible applications in medicine and radiation protection. In particular, some works analysed the early stages of the interaction between ionizing radiation and DNA focusing on DNA cluster damage, which is widely considered as an important step towards subsequent endpoints. Other studies investigated the consequences of hypoxia on the evolution of the initial DNA damage, and one work analysed genome-wide DNA alterations in irradiated human cells. Concerning radiation therapy, the response of cancer cells to different radiation types was characterized both in vitro and in vivo, and possible strategies to enhance such response were investigated; furthermore, FLASH radiotherapy was reviewed. In the framework of cancer therapy side effects, the consequences of high doses on gene expression in healthy cells were analyzed, and the RBE (Relative Biological Effectiveness) for late effects in the central nervous system was predicted by the BIANCA biophysical model. Finally, the protective role of melatonin and Vitamin D, as well as hypothermia, was reviewed, valine radiolysis was investigated, the changes in radio-sensitivity of embrios during the early developmental stages of the preimplantation were analyzed, and epigenetic modifications induced by ionizing radiation were reviewed. |
| format | Online |
| id | doab-20.500.12854ir-100127 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1001272024-03-28T03:30:41Z Radiation Damage in Biomolecules and Cells Ballarini, Francesca Carante, Mario Pietro glioblastoma multiforme proton therapy combined treatments gene signatures brain arteriovenous malformation endothelial cells ionizing radiation proteomics stereotactic radiosurgery vascular targeting DNA repair hypoxia modeling radiosensitizer Monte Carlo simulation Geant4/Geant4-DNA X-rays microdosimetry nanodosimetry DSB yield radiation track chemistry chemical track structure oxygen effect oxygen depletion ion beam therapy ROS superoxide anion Monte Carlo radiation transport complex DNA damage coupled with base damage modelling of DNA damage yields amino acid valine MeV ion irradiation radiolysis infrared absorption spectroscopy destruction cross section stopping power dependence carbon ions radiation-induced damage chromatin structure electron microscopy CLEM DNA and RNA cytochemistry Osmium ammine B ChromEMT DNA-specific staining high-dose ionizing radiation RNA-Seq differential gene expression DNA damage response triple-negative breast cancer CHK1 Rad51 direct and indirect damage DMSO radicals radical scavengers Glioblastoma DNA damage head-and-neck tumors ion beam radiotherapy relative biological effectiveness (RBE) RBE models protons Monte Carlo simulations embryo gastrulation preimplantation apoptosis glioblastoma stem cells metabolism MRS photon beams pencil beam scanning double scattering cell survival radiation doses repair mechanism translocation transition transversion ratio IR-induced variants SNVs InDels topological associating domains melatonin oxidative stress radioprotection reactive oxygen species vitamin D radiation biology radiation protection health effects epigenetics low dose radiation DNA methylation non-targeted effects triple-negative breast cancer (TNBC) xenograft mice microarray environmental radiation hibernation HIF-1 hypothermia radioresistance space travel FLASH proton beam therapy radiotherapy radiobiology n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The papers collected in this Special Issue deal with the effects of ionizing radiation at molecular and cellular levels, as well as possible applications in medicine and radiation protection. In particular, some works analysed the early stages of the interaction between ionizing radiation and DNA focusing on DNA cluster damage, which is widely considered as an important step towards subsequent endpoints. Other studies investigated the consequences of hypoxia on the evolution of the initial DNA damage, and one work analysed genome-wide DNA alterations in irradiated human cells. Concerning radiation therapy, the response of cancer cells to different radiation types was characterized both in vitro and in vivo, and possible strategies to enhance such response were investigated; furthermore, FLASH radiotherapy was reviewed. In the framework of cancer therapy side effects, the consequences of high doses on gene expression in healthy cells were analyzed, and the RBE (Relative Biological Effectiveness) for late effects in the central nervous system was predicted by the BIANCA biophysical model. Finally, the protective role of melatonin and Vitamin D, as well as hypothermia, was reviewed, valine radiolysis was investigated, the changes in radio-sensitivity of embrios during the early developmental stages of the preimplantation were analyzed, and epigenetic modifications induced by ionizing radiation were reviewed. 2023-05-11T17:22:05Z 2023-05-11T17:22:05Z 2023 book ONIX_20230511_9783036574875_144 9783036574875 9783036574868 https://directory.doabooks.org/handle/20.500.12854/100127 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7221 https://mdpi.com/books/pdfview/book/7221 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7486-8 10.3390/books978-3-0365-7486-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036574875 9783036574868 398 Basel open access |
| spellingShingle | glioblastoma multiforme proton therapy combined treatments gene signatures brain arteriovenous malformation endothelial cells ionizing radiation proteomics stereotactic radiosurgery vascular targeting DNA repair hypoxia modeling radiosensitizer Monte Carlo simulation Geant4/Geant4-DNA X-rays microdosimetry nanodosimetry DSB yield radiation track chemistry chemical track structure oxygen effect oxygen depletion ion beam therapy ROS superoxide anion Monte Carlo radiation transport complex DNA damage coupled with base damage modelling of DNA damage yields amino acid valine MeV ion irradiation radiolysis infrared absorption spectroscopy destruction cross section stopping power dependence carbon ions radiation-induced damage chromatin structure electron microscopy CLEM DNA and RNA cytochemistry Osmium ammine B ChromEMT DNA-specific staining high-dose ionizing radiation RNA-Seq differential gene expression DNA damage response triple-negative breast cancer CHK1 Rad51 direct and indirect damage DMSO radicals radical scavengers Glioblastoma DNA damage head-and-neck tumors ion beam radiotherapy relative biological effectiveness (RBE) RBE models protons Monte Carlo simulations embryo gastrulation preimplantation apoptosis glioblastoma stem cells metabolism MRS photon beams pencil beam scanning double scattering cell survival radiation doses repair mechanism translocation transition transversion ratio IR-induced variants SNVs InDels topological associating domains melatonin oxidative stress radioprotection reactive oxygen species vitamin D radiation biology radiation protection health effects epigenetics low dose radiation DNA methylation non-targeted effects triple-negative breast cancer (TNBC) xenograft mice microarray environmental radiation hibernation HIF-1 hypothermia radioresistance space travel FLASH proton beam therapy radiotherapy radiobiology n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Radiation Damage in Biomolecules and Cells |
| title | Radiation Damage in Biomolecules and Cells |
| title_full | Radiation Damage in Biomolecules and Cells |
| title_fullStr | Radiation Damage in Biomolecules and Cells |
| title_full_unstemmed | Radiation Damage in Biomolecules and Cells |
| title_short | Radiation Damage in Biomolecules and Cells |
| title_sort | radiation damage in biomolecules and cells |
| topic | glioblastoma multiforme proton therapy combined treatments gene signatures brain arteriovenous malformation endothelial cells ionizing radiation proteomics stereotactic radiosurgery vascular targeting DNA repair hypoxia modeling radiosensitizer Monte Carlo simulation Geant4/Geant4-DNA X-rays microdosimetry nanodosimetry DSB yield radiation track chemistry chemical track structure oxygen effect oxygen depletion ion beam therapy ROS superoxide anion Monte Carlo radiation transport complex DNA damage coupled with base damage modelling of DNA damage yields amino acid valine MeV ion irradiation radiolysis infrared absorption spectroscopy destruction cross section stopping power dependence carbon ions radiation-induced damage chromatin structure electron microscopy CLEM DNA and RNA cytochemistry Osmium ammine B ChromEMT DNA-specific staining high-dose ionizing radiation RNA-Seq differential gene expression DNA damage response triple-negative breast cancer CHK1 Rad51 direct and indirect damage DMSO radicals radical scavengers Glioblastoma DNA damage head-and-neck tumors ion beam radiotherapy relative biological effectiveness (RBE) RBE models protons Monte Carlo simulations embryo gastrulation preimplantation apoptosis glioblastoma stem cells metabolism MRS photon beams pencil beam scanning double scattering cell survival radiation doses repair mechanism translocation transition transversion ratio IR-induced variants SNVs InDels topological associating domains melatonin oxidative stress radioprotection reactive oxygen species vitamin D radiation biology radiation protection health effects epigenetics low dose radiation DNA methylation non-targeted effects triple-negative breast cancer (TNBC) xenograft mice microarray environmental radiation hibernation HIF-1 hypothermia radioresistance space travel FLASH proton beam therapy radiotherapy radiobiology n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | glioblastoma multiforme proton therapy combined treatments gene signatures brain arteriovenous malformation endothelial cells ionizing radiation proteomics stereotactic radiosurgery vascular targeting DNA repair hypoxia modeling radiosensitizer Monte Carlo simulation Geant4/Geant4-DNA X-rays microdosimetry nanodosimetry DSB yield radiation track chemistry chemical track structure oxygen effect oxygen depletion ion beam therapy ROS superoxide anion Monte Carlo radiation transport complex DNA damage coupled with base damage modelling of DNA damage yields amino acid valine MeV ion irradiation radiolysis infrared absorption spectroscopy destruction cross section stopping power dependence carbon ions radiation-induced damage chromatin structure electron microscopy CLEM DNA and RNA cytochemistry Osmium ammine B ChromEMT DNA-specific staining high-dose ionizing radiation RNA-Seq differential gene expression DNA damage response triple-negative breast cancer CHK1 Rad51 direct and indirect damage DMSO radicals radical scavengers Glioblastoma DNA damage head-and-neck tumors ion beam radiotherapy relative biological effectiveness (RBE) RBE models protons Monte Carlo simulations embryo gastrulation preimplantation apoptosis glioblastoma stem cells metabolism MRS photon beams pencil beam scanning double scattering cell survival radiation doses repair mechanism translocation transition transversion ratio IR-induced variants SNVs InDels topological associating domains melatonin oxidative stress radioprotection reactive oxygen species vitamin D radiation biology radiation protection health effects epigenetics low dose radiation DNA methylation non-targeted effects triple-negative breast cancer (TNBC) xenograft mice microarray environmental radiation hibernation HIF-1 hypothermia radioresistance space travel FLASH proton beam therapy radiotherapy radiobiology n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230511_9783036574875_144 |