Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach
Although DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repai...
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| フォーマット: | Online |
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| 言語: | 英語 |
| 出版事項: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| オンライン･アクセス: | ONIX_20230714_9783036578811_72 |
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| _version_ | 1869525114651934720 |
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| collection | Directory of Open Access Books |
| description | Although DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repair enzymes could help to overcome this resistance. The reviews and research articles included in this collection describe the molecular mechanisms of action of some important enzymes of the DNA repair system, as well as some new inhibitors of such enzymes and the pharmacological properties of these inhibitors. This reprint clearly demonstrates the importance of the inhibition of DNA repair enzymes to fight various diseases, especially cancer. |
| format | Online |
| id | doab-20.500.12854ir-101373 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1013732024-03-28T03:33:44Z Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach Volcho, Konstantin Lavrik, Olga poly (ADP-ribose) polymerase inhibitor non-small cell lung cancer DNA damage radiotherapy chemotherapy combination therapy coumarin neoflavone DNA repair enzymes Tdp1 inhibitor cancer tumor topotecan topoisomerase 1 inhibitors molecular modeling chemical space morpholino nucleosides NAD+ analogs DNA repair PARP 7-methylguanine poly(ADP-ribose) polymerase 1 inhibitor nucleosome trapping docking molecular dynamics fluorescence anisotropy spFRET microscopy DNA glycosylases drug targets APE1 protein–protein interactions base excision repair multifunctional disordered protein fluorescence techniques cell cycle checkpoint cancer therapy DNA repair inhibitors synthetic lethality fused in sarcoma poly(ADP-ribose) polymerase poly(ADP-ribose) protein phase separation berberine tetrahydroberberine DNA repair enzyme SAR poly(ADP-ribosylation) PARP-1 Olaparib KU55933 KU-0060648 SCR7 pyrazine VERO cells synergism resistance CDKN2A soft tissue sarcomas (STS) gastrointestinal stromal tumors (GIST) AKT signaling Rad51 recombinase homology-mediated DNA repair apoptosis sensitization XPA ERCC1-XPF CSB UVB radiation UVB mutagenesis nucleotide excision repair (NER) cyclobutane–pyrimidine dimer (CPD) photolesion veliparib resveratrol arsenic trioxide spironolactone usnic acid thioether tyrosyl-DNA phosphodiesterase 1 TDP1 inhibitor inhibiting activity TDP2 PARP1 synergy HEK293 knockout cell line polyphenols PARP-1 inhibitors n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Although DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repair enzymes could help to overcome this resistance. The reviews and research articles included in this collection describe the molecular mechanisms of action of some important enzymes of the DNA repair system, as well as some new inhibitors of such enzymes and the pharmacological properties of these inhibitors. This reprint clearly demonstrates the importance of the inhibition of DNA repair enzymes to fight various diseases, especially cancer. 2023-07-14T14:28:09Z 2023-07-14T14:28:09Z 2023 book ONIX_20230714_9783036578811_72 9783036578811 9783036578804 https://directory.doabooks.org/handle/20.500.12854/101373 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7469 https://mdpi.com/books/pdfview/book/7469 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7880-4 10.3390/books978-3-0365-7880-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036578811 9783036578804 316 Basel open access |
| spellingShingle | poly (ADP-ribose) polymerase inhibitor non-small cell lung cancer DNA damage radiotherapy chemotherapy combination therapy coumarin neoflavone DNA repair enzymes Tdp1 inhibitor cancer tumor topotecan topoisomerase 1 inhibitors molecular modeling chemical space morpholino nucleosides NAD+ analogs DNA repair PARP 7-methylguanine poly(ADP-ribose) polymerase 1 inhibitor nucleosome trapping docking molecular dynamics fluorescence anisotropy spFRET microscopy DNA glycosylases drug targets APE1 protein–protein interactions base excision repair multifunctional disordered protein fluorescence techniques cell cycle checkpoint cancer therapy DNA repair inhibitors synthetic lethality fused in sarcoma poly(ADP-ribose) polymerase poly(ADP-ribose) protein phase separation berberine tetrahydroberberine DNA repair enzyme SAR poly(ADP-ribosylation) PARP-1 Olaparib KU55933 KU-0060648 SCR7 pyrazine VERO cells synergism resistance CDKN2A soft tissue sarcomas (STS) gastrointestinal stromal tumors (GIST) AKT signaling Rad51 recombinase homology-mediated DNA repair apoptosis sensitization XPA ERCC1-XPF CSB UVB radiation UVB mutagenesis nucleotide excision repair (NER) cyclobutane–pyrimidine dimer (CPD) photolesion veliparib resveratrol arsenic trioxide spironolactone usnic acid thioether tyrosyl-DNA phosphodiesterase 1 TDP1 inhibitor inhibiting activity TDP2 PARP1 synergy HEK293 knockout cell line polyphenols PARP-1 inhibitors n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach |
| title | Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach |
| title_full | Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach |
| title_fullStr | Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach |
| title_full_unstemmed | Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach |
| title_short | Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach |
| title_sort | inhibition of dna repair enzymes as a valuable pharmaceutical approach |
| topic | poly (ADP-ribose) polymerase inhibitor non-small cell lung cancer DNA damage radiotherapy chemotherapy combination therapy coumarin neoflavone DNA repair enzymes Tdp1 inhibitor cancer tumor topotecan topoisomerase 1 inhibitors molecular modeling chemical space morpholino nucleosides NAD+ analogs DNA repair PARP 7-methylguanine poly(ADP-ribose) polymerase 1 inhibitor nucleosome trapping docking molecular dynamics fluorescence anisotropy spFRET microscopy DNA glycosylases drug targets APE1 protein–protein interactions base excision repair multifunctional disordered protein fluorescence techniques cell cycle checkpoint cancer therapy DNA repair inhibitors synthetic lethality fused in sarcoma poly(ADP-ribose) polymerase poly(ADP-ribose) protein phase separation berberine tetrahydroberberine DNA repair enzyme SAR poly(ADP-ribosylation) PARP-1 Olaparib KU55933 KU-0060648 SCR7 pyrazine VERO cells synergism resistance CDKN2A soft tissue sarcomas (STS) gastrointestinal stromal tumors (GIST) AKT signaling Rad51 recombinase homology-mediated DNA repair apoptosis sensitization XPA ERCC1-XPF CSB UVB radiation UVB mutagenesis nucleotide excision repair (NER) cyclobutane–pyrimidine dimer (CPD) photolesion veliparib resveratrol arsenic trioxide spironolactone usnic acid thioether tyrosyl-DNA phosphodiesterase 1 TDP1 inhibitor inhibiting activity TDP2 PARP1 synergy HEK293 knockout cell line polyphenols PARP-1 inhibitors n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | poly (ADP-ribose) polymerase inhibitor non-small cell lung cancer DNA damage radiotherapy chemotherapy combination therapy coumarin neoflavone DNA repair enzymes Tdp1 inhibitor cancer tumor topotecan topoisomerase 1 inhibitors molecular modeling chemical space morpholino nucleosides NAD+ analogs DNA repair PARP 7-methylguanine poly(ADP-ribose) polymerase 1 inhibitor nucleosome trapping docking molecular dynamics fluorescence anisotropy spFRET microscopy DNA glycosylases drug targets APE1 protein–protein interactions base excision repair multifunctional disordered protein fluorescence techniques cell cycle checkpoint cancer therapy DNA repair inhibitors synthetic lethality fused in sarcoma poly(ADP-ribose) polymerase poly(ADP-ribose) protein phase separation berberine tetrahydroberberine DNA repair enzyme SAR poly(ADP-ribosylation) PARP-1 Olaparib KU55933 KU-0060648 SCR7 pyrazine VERO cells synergism resistance CDKN2A soft tissue sarcomas (STS) gastrointestinal stromal tumors (GIST) AKT signaling Rad51 recombinase homology-mediated DNA repair apoptosis sensitization XPA ERCC1-XPF CSB UVB radiation UVB mutagenesis nucleotide excision repair (NER) cyclobutane–pyrimidine dimer (CPD) photolesion veliparib resveratrol arsenic trioxide spironolactone usnic acid thioether tyrosyl-DNA phosphodiesterase 1 TDP1 inhibitor inhibiting activity TDP2 PARP1 synergy HEK293 knockout cell line polyphenols PARP-1 inhibitors n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230714_9783036578811_72 |