Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach

Although DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repai...

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Библиографические подробности
Формат:	Online
Язык:	английский
Опубликовано:	MDPI - Multidisciplinary Digital Publishing Institute 2023
Предметы:	poly (ADP-ribose) polymerase inhibitor non-small cell lung cancer DNA damage radiotherapy chemotherapy combination therapy coumarin neoflavone DNA repair enzymes Tdp1 inhibitor cancer tumor topotecan topoisomerase 1 inhibitors molecular modeling chemical space morpholino nucleosides NAD+ analogs DNA repair PARP 7-methylguanine poly(ADP-ribose) polymerase 1 inhibitor nucleosome trapping docking molecular dynamics fluorescence anisotropy spFRET microscopy DNA glycosylases drug targets APE1 protein–protein interactions base excision repair multifunctional disordered protein fluorescence techniques cell cycle checkpoint cancer therapy DNA repair inhibitors synthetic lethality fused in sarcoma poly(ADP-ribose) polymerase poly(ADP-ribose) protein phase separation berberine tetrahydroberberine DNA repair enzyme SAR poly(ADP-ribosylation) PARP-1 Olaparib KU55933 KU-0060648 SCR7 pyrazine VERO cells synergism resistance CDKN2A soft tissue sarcomas (STS) gastrointestinal stromal tumors (GIST) AKT signaling Rad51 recombinase homology-mediated DNA repair apoptosis sensitization XPA ERCC1-XPF CSB UVB radiation UVB mutagenesis nucleotide excision repair (NER) cyclobutane–pyrimidine dimer (CPD) photolesion veliparib resveratrol arsenic trioxide spironolactone usnic acid thioether tyrosyl-DNA phosphodiesterase 1 TDP1 inhibitor inhibiting activity TDP2 PARP1 synergy HEK293 knockout cell line polyphenols PARP-1 inhibitors n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online-ссылка:	ONIX_20230714_9783036578811_72
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Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach

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