Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance
In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative c...
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| Hoofdauteurs: | , |
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| Formaat: | Online |
| Taal: | Engels |
| Gepubliceerd in: |
CABI
2023
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| Onderwerpen: | |
| Online toegang: | https://library.oapen.org/handle/20.500.12657/63877 |
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| Samenvatting: | In this chapter, we outline a range of
modelling approaches that have been used
to demonstrate the key characteristics of
this approach, including threshold introduction
frequencies, reversibility, spatial limitation
and robustness to mutation/resistance.
We then go on to discuss alternative configurations
based on the use of sex-specific
components and their effect on introduction
thresholds. We conclude with a discussion on the cycle of information between mathematical
models and experimental data along
with a range of areas for future modelling
that will be important in providing information
on the anticipated effects of these systems
when released into target populations. |
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