Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance
In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative c...
Furkejuvvon:
| Váldodahkkit: | , |
|---|---|
| Materiálatiipa: | Online |
| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
CABI
2023
|
| Fáttát: | |
| Liŋkkat: | https://library.oapen.org/handle/20.500.12657/63877 |
| Fáddágilkorat: |
Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!
|
| _version_ | 1869526394390708224 |
|---|---|
| author | Edgington, Matthew P. Alphey, Luke |
| author_browse | Alphey, Luke Edgington, Matthew P. |
| author_facet | Edgington, Matthew P. Alphey, Luke |
| author_sort | Edgington, Matthew P. |
| collection | Directory of Open Access Books |
| description | In this chapter, we outline a range of
modelling approaches that have been used
to demonstrate the key characteristics of
this approach, including threshold introduction
frequencies, reversibility, spatial limitation
and robustness to mutation/resistance.
We then go on to discuss alternative configurations
based on the use of sex-specific
components and their effect on introduction
thresholds. We conclude with a discussion on the cycle of information between mathematical
models and experimental data along
with a range of areas for future modelling
that will be important in providing information
on the anticipated effects of these systems
when released into target populations. |
| format | Online |
| id | doab-20.500.12854ir-101467 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | CABI |
| publisherStr | CABI |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1014672025-07-17T10:01:07Z Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance Edgington, Matthew P. Alphey, Luke gene drives; engineerd underdominance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configurations based on the use of sex-specific components and their effect on introduction thresholds. We conclude with a discussion on the cycle of information between mathematical models and experimental data along with a range of areas for future modelling that will be important in providing information on the anticipated effects of these systems when released into target populations. 2023-07-18T04:43:36Z 2023-07-18T04:43:36Z 2023-07-12T13:31:41Z 2022 chapter https://library.oapen.org/handle/20.500.12657/63877 9781800621152 9781800621176 https://directory.doabooks.org/handle/20.500.12854/101467 eng open access image/jpeg image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International Attribution-NonCommercial-NoDerivatives 4.0 International https://library.oapen.org/bitstream/20.500.12657/63877/1/Bookshelf_NBK588732.pdf https://library.oapen.org/bitstream/20.500.12657/63877/1/Bookshelf_NBK588732.pdf CABI 10.1079/9781800621176.0012 10.1079/9781800621176.0012 f69fb9b2-0428-45ab-aaf5-f4bd898185c7 Transgenic Insects Wellcome Trust d859fbd3-d884-4090-a0ec-baf821c9abfd 9781800621152 9781800621176 Wellcome 20 110117/Z/15/Z open access |
| spellingShingle | gene drives; engineerd underdominance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Edgington, Matthew P. Alphey, Luke Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance |
| title | Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance |
| title_full | Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance |
| title_fullStr | Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance |
| title_full_unstemmed | Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance |
| title_short | Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance |
| title_sort | chapter 12 modelling threshold dependent gene drives a case study using engineered underdominance |
| topic | gene drives; engineerd underdominance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | gene drives; engineerd underdominance thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | https://library.oapen.org/handle/20.500.12657/63877 |
| work_keys_str_mv | AT edgingtonmatthewp chapter12modellingthresholddependentgenedrivesacasestudyusingengineeredunderdominance AT alpheyluke chapter12modellingthresholddependentgenedrivesacasestudyusingengineeredunderdominance |