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PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer

This Special Issue of Cancers contains research and review articles on “PARPs, PAR and NAD metabolism and their inhibitors in Cancer”. It focuses on selected papers from the PARP2019 conference on “New Avenues in Basic and Translational PARP research”, that took place in Budapest (Hungary), on 20–23...

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Guardat en:
Format: Online
Idioma:anglès
Publicat: MDPI - Multidisciplinary Digital Publishing Institute 2023
Matèries:
MDS
PARP inhibitors
olaparib
hematopoietic differentiation
PARP1
AML
poly-ADP-ribose polymerase 1 (PARP1)
brahma-related gene 1 (BRG1)
histone acetyltransferase p300 (EP300)
gene transcription
cancer cell
head and neck squamous cell carcinoma
CAL27
SCC90
p60/p150 CAF-1 subunits
DNA repair
homologous recombination
biomarkers
personalized treatment
UVB
PARP
mitochondria
metabolism
biogenesis
autophagy
carcinogenesis
transcription
PARylation
DNA damage
transcription silencing
carryover effect
TOP1 activity
TDP1
irinotecan
immunomodulation
tumor microenvironment
trapping
cancer therapeutic strategy
arginine-specific mono-ADP-ribosylation
bacterial toxin
cholera toxin
ART1
ARH1
tumorigenesis
loss of heterozygosity
membrane repair
gender bias
Syk
EGFR
squamous cell carcinoma
PARP-Akt interplay
PI3K
mTOR
cytoprotection
apoptosis resistance
oxidative stress
mitochondrial protection
drug development
synthetic lethality
clinical trials
ADP-ribosylation
cancer
macrodomain
ADP-ribosyl hydrolase
ARTD
MACROD1
MACROD2
TARG1
ATM
ATR
PARP inhibitor
prostate cancer
pancreatic cancer
lung cancer
Tumor microenvironment
PARPs
hypoxia
CHK1
replication stress
homologous recombination DNA repair
cell cycle
cytotoxicity
PARP Inhibitors
beta-lapachone
NQO1
PARG
NAMPT
cancer therapeutics
cMET
poly (ADP-ribose) glycohydrolase
radiosensitization
poly (ADP-ribose) polymerase
ES cells
poly (ADP-ribose) polymerase inhibitors (PARPi)
ataxia telangiectasia and Rad3 related inhibitors (ATRi)
cell cycle checkpoints
NAD+
NMNAT1
cisplatin
chemotherapy
apoptosis
osteosarcoma
DNA damage response
immunotherapy
immune checkpoint inhibitor
PD-1
PD-L1
CTLA-4
combination therapy
solid tumors
the PARP inhibitor PJ34
distorted mitotic spindles
exclusive eradication of human cancer cells
nucleolus
poly(ADP-ribosyl)ation
ARTDs
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
Accés en línia:ONIX_20230808_9783036581569_37
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Sumari:This Special Issue of Cancers contains research and review articles on “PARPs, PAR and NAD metabolism and their inhibitors in Cancer”. It focuses on selected papers from the PARP2019 conference on “New Avenues in Basic and Translational PARP research”, that took place in Budapest (Hungary), on 20–23 May 2019.

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