PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer

This Special Issue of Cancers contains research and review articles on “PARPs, PAR and NAD metabolism and their inhibitors in Cancer”. It focuses on selected papers from the PARP2019 conference on “New Avenues in Basic and Translational PARP research”, that took place in Budapest (Hungary), on 20–23...

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書目詳細資料
格式:	Online
語言:	英语
出版:	MDPI - Multidisciplinary Digital Publishing Institute 2023
主題:	MDS PARP inhibitors olaparib hematopoietic differentiation PARP1 AML poly-ADP-ribose polymerase 1 (PARP1) brahma-related gene 1 (BRG1) histone acetyltransferase p300 (EP300) gene transcription cancer cell head and neck squamous cell carcinoma CAL27 SCC90 p60/p150 CAF-1 subunits DNA repair homologous recombination biomarkers personalized treatment UVB PARP mitochondria metabolism biogenesis autophagy carcinogenesis transcription PARylation DNA damage transcription silencing carryover effect TOP1 activity TDP1 irinotecan immunomodulation tumor microenvironment trapping cancer therapeutic strategy arginine-specific mono-ADP-ribosylation bacterial toxin cholera toxin ART1 ARH1 tumorigenesis loss of heterozygosity membrane repair gender bias Syk EGFR squamous cell carcinoma PARP-Akt interplay PI3K mTOR cytoprotection apoptosis resistance oxidative stress mitochondrial protection drug development synthetic lethality clinical trials ADP-ribosylation cancer macrodomain ADP-ribosyl hydrolase ARTD MACROD1 MACROD2 TARG1 ATM ATR PARP inhibitor prostate cancer pancreatic cancer lung cancer Tumor microenvironment PARPs hypoxia CHK1 replication stress homologous recombination DNA repair cell cycle cytotoxicity PARP Inhibitors beta-lapachone NQO1 PARG NAMPT cancer therapeutics cMET poly (ADP-ribose) glycohydrolase radiosensitization poly (ADP-ribose) polymerase ES cells poly (ADP-ribose) polymerase inhibitors (PARPi) ataxia telangiectasia and Rad3 related inhibitors (ATRi) cell cycle checkpoints NAD+ NMNAT1 cisplatin chemotherapy apoptosis osteosarcoma DNA damage response immunotherapy immune checkpoint inhibitor PD-1 PD-L1 CTLA-4 combination therapy solid tumors the PARP inhibitor PJ34 distorted mitotic spindles exclusive eradication of human cancer cells nucleolus poly(ADP-ribosyl)ation ARTDs n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
在線閱讀:	ONIX_20230808_9783036581569_37
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PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer

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