Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes
This Special Issue covers an important topic that has relevance not only from a scientific point of view but also from nutritional, policy, and industrial perspectives. We are currently being subjected to increasing obesogenic pressures, with sugars being hidden in many foods, creating the perfect e...
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| Format: | Online |
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| Jezik: | angleščina |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online dostop: | ONIX_20230808_9783036581422_15 |
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| collection | Directory of Open Access Books |
| description | This Special Issue covers an important topic that has relevance not only from a scientific point of view but also from nutritional, policy, and industrial perspectives. We are currently being subjected to increasing obesogenic pressures, with sugars being hidden in many foods, creating the perfect environment for the slow but consistent progression of metabolic dysfunction. The consumption and impact of dietary sugars on the gastrointestinal system is discussed, together with the dietary sources of naturally occurring and added sugars, as well as the role of different diets and dietary regimens in preventing post-prandial sugar increases and hyperinsulinemia. The intestinal metabolism of dietary sugars, including the formation and absorption of advanced glycation end products and their impact on gut microbiota, is also considered. In terms of the impact of dietary sugars on other metabolic processes, the increased and sustained consumption of sugars causes long-term alterations in beta-cell function and the hypothalamic pathways controlling energy balance and the development of addictive behaviors, inducing mitochondrial impairment, oxidative stress, and the modulation of inflammatory pathways. Seeking to advance the development of prevention strategies to avoid the negative impact of dietary sugars, we outline the role of exercise in reducing blood markers of glucose dysmetabolism and the importance of preventing excessive sugar consumption in critical phases of development owing to its long-term consequences. Additionally, we discuss pathophysiological processes and mechanisms of disease. |
| format | Online |
| id | doab-20.500.12854ir-112509 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1125092024-04-01T23:19:16Z Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes Matafome, Paulo sugars nutritive sweeteners non-nutritive sweeteners gut microbiota metabolic health industrialized food dietary sugars metabolic dysfunction maternal high-sugar diet disease programming glycation glycotoxins AGEs digestion intestinal absorption daily insulin fluctuation insulin sensitivity diets circadian rhythm sugar intake free sugars added sugars diabetes hypothalamus hypercaloric diets sugar satiety pathways type 2 diabetes exercise glycated haemoglobin blood glucose nutrition immunomodulation inflammation insulin resistance sugar metabolism adipose tissue pancreatic β-cell insulin diet sugar consumption n/a DOHaD pregnancy lactation childhood obesity thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues This Special Issue covers an important topic that has relevance not only from a scientific point of view but also from nutritional, policy, and industrial perspectives. We are currently being subjected to increasing obesogenic pressures, with sugars being hidden in many foods, creating the perfect environment for the slow but consistent progression of metabolic dysfunction. The consumption and impact of dietary sugars on the gastrointestinal system is discussed, together with the dietary sources of naturally occurring and added sugars, as well as the role of different diets and dietary regimens in preventing post-prandial sugar increases and hyperinsulinemia. The intestinal metabolism of dietary sugars, including the formation and absorption of advanced glycation end products and their impact on gut microbiota, is also considered. In terms of the impact of dietary sugars on other metabolic processes, the increased and sustained consumption of sugars causes long-term alterations in beta-cell function and the hypothalamic pathways controlling energy balance and the development of addictive behaviors, inducing mitochondrial impairment, oxidative stress, and the modulation of inflammatory pathways. Seeking to advance the development of prevention strategies to avoid the negative impact of dietary sugars, we outline the role of exercise in reducing blood markers of glucose dysmetabolism and the importance of preventing excessive sugar consumption in critical phases of development owing to its long-term consequences. Additionally, we discuss pathophysiological processes and mechanisms of disease. 2023-08-08T15:23:58Z 2023-08-08T15:23:58Z 2023 book ONIX_20230808_9783036581422_15 9783036581422 9783036581439 https://directory.doabooks.org/handle/20.500.12854/112509 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7628 https://mdpi.com/books/pdfview/book/7628 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8143-9 10.3390/books978-3-0365-8143-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036581422 9783036581439 114 Basel open access |
| spellingShingle | sugars nutritive sweeteners non-nutritive sweeteners gut microbiota metabolic health industrialized food dietary sugars metabolic dysfunction maternal high-sugar diet disease programming glycation glycotoxins AGEs digestion intestinal absorption daily insulin fluctuation insulin sensitivity diets circadian rhythm sugar intake free sugars added sugars diabetes hypothalamus hypercaloric diets sugar satiety pathways type 2 diabetes exercise glycated haemoglobin blood glucose nutrition immunomodulation inflammation insulin resistance sugar metabolism adipose tissue pancreatic β-cell insulin diet sugar consumption n/a DOHaD pregnancy lactation childhood obesity thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes |
| title | Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes |
| title_full | Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes |
| title_fullStr | Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes |
| title_full_unstemmed | Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes |
| title_short | Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes |
| title_sort | nutritional modulation of dietary sugars as a strategy to improve insulin resistance and energy balance in diabetes |
| topic | sugars nutritive sweeteners non-nutritive sweeteners gut microbiota metabolic health industrialized food dietary sugars metabolic dysfunction maternal high-sugar diet disease programming glycation glycotoxins AGEs digestion intestinal absorption daily insulin fluctuation insulin sensitivity diets circadian rhythm sugar intake free sugars added sugars diabetes hypothalamus hypercaloric diets sugar satiety pathways type 2 diabetes exercise glycated haemoglobin blood glucose nutrition immunomodulation inflammation insulin resistance sugar metabolism adipose tissue pancreatic β-cell insulin diet sugar consumption n/a DOHaD pregnancy lactation childhood obesity thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| topic_facet | sugars nutritive sweeteners non-nutritive sweeteners gut microbiota metabolic health industrialized food dietary sugars metabolic dysfunction maternal high-sugar diet disease programming glycation glycotoxins AGEs digestion intestinal absorption daily insulin fluctuation insulin sensitivity diets circadian rhythm sugar intake free sugars added sugars diabetes hypothalamus hypercaloric diets sugar satiety pathways type 2 diabetes exercise glycated haemoglobin blood glucose nutrition immunomodulation inflammation insulin resistance sugar metabolism adipose tissue pancreatic β-cell insulin diet sugar consumption n/a DOHaD pregnancy lactation childhood obesity thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| url | ONIX_20230808_9783036581422_15 |