Chapter 11 Vitamin C and the Brain
The brain requires vitamin C to metabolize fuel substrates and synthesize neurotransmitters, regulate their release, and modify their actions. Vitamin C also protects the brain from oxidative damage. Clinical studies do not provide strong evidence that vitamin C deficiency directly impairs brain fun...
-д хадгалсан:
| Үндсэн зохиолч: | |
|---|---|
| Формат: | Online |
| Хэл сонгох: | англи |
| Хэвлэсэн: |
Taylor & Francis
2023
|
| Нөхцлүүд: | |
| Онлайн хандалт: | https://library.oapen.org/handle/20.500.12657/75335 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
|
| _version_ | 1869519740710420480 |
|---|---|
| author | Hoffer, Leonard John |
| author_browse | Hoffer, Leonard John |
| author_facet | Hoffer, Leonard John |
| author_sort | Hoffer, Leonard John |
| collection | Directory of Open Access Books |
| description | The brain requires vitamin C to metabolize fuel substrates and synthesize neurotransmitters, regulate their release, and modify their actions. Vitamin C also protects the brain from oxidative damage. Clinical studies do not provide strong evidence that vitamin C deficiency directly impairs brain function but rather suggest that the fatigue, mood disturbance, and cognitive dysfunction sometimes associated with vitamin C deficiency are due to peripheral tissue damage, with possibly an exaggerated emotional response to it. Severe brain injury drastically depletes the cerebrospinal fluid of vitamin C; clinical trials of high-dose intravenous vitamin C are strongly warranted for this condition. The very limited clinical trial evidence available does not demonstrate that vitamin C supplementation slows the progression of dementia or improves clinical outcomes after an acute ischemic stroke. Hypovitaminosis C is common in people with severe mental illness; it should be treated. A few clinical trials have been carried out of low-pharmacologic doses of vitamin C (alone or with other nutrients) as adjunctive therapy in patients with chronic stable schizophrenia or depression, with inconsistent results. There is plausible but inclusive evidence that continuous supplementation with a combination of several micronutrients, including vitamin C, may have cognitive benefits in some people even if they lack diagnosed vitamin deficiencies. |
| format | Online |
| id | doab-20.500.12854ir-112600 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1126002025-07-17T10:00:01Z Chapter 11 Vitamin C and the Brain Hoffer, Leonard John Antioxidants, Ascorbic Acid, Infectious Disease, Intravenous Ascorbate, Vitamin C, acute sepsis, cancer treatment, infectious disease treatment, stem cell transplantation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The brain requires vitamin C to metabolize fuel substrates and synthesize neurotransmitters, regulate their release, and modify their actions. Vitamin C also protects the brain from oxidative damage. Clinical studies do not provide strong evidence that vitamin C deficiency directly impairs brain function but rather suggest that the fatigue, mood disturbance, and cognitive dysfunction sometimes associated with vitamin C deficiency are due to peripheral tissue damage, with possibly an exaggerated emotional response to it. Severe brain injury drastically depletes the cerebrospinal fluid of vitamin C; clinical trials of high-dose intravenous vitamin C are strongly warranted for this condition. The very limited clinical trial evidence available does not demonstrate that vitamin C supplementation slows the progression of dementia or improves clinical outcomes after an acute ischemic stroke. Hypovitaminosis C is common in people with severe mental illness; it should be treated. A few clinical trials have been carried out of low-pharmacologic doses of vitamin C (alone or with other nutrients) as adjunctive therapy in patients with chronic stable schizophrenia or depression, with inconsistent results. There is plausible but inclusive evidence that continuous supplementation with a combination of several micronutrients, including vitamin C, may have cognitive benefits in some people even if they lack diagnosed vitamin deficiencies. 2023-08-11T04:02:08Z 2023-08-11T04:02:08Z 2023-08-10T12:19:29Z 2020 chapter https://library.oapen.org/handle/20.500.12657/75335 9781138337992 9781032175256 https://directory.doabooks.org/handle/20.500.12854/112600 eng open access image/jpeg image/jpeg Attribution-NonCommercial 4.0 International Attribution-NonCommercial 4.0 International https://library.oapen.org/bitstream/20.500.12657/75335/1/9780429442025_10.1201_9780429442025-11.pdf https://library.oapen.org/bitstream/20.500.12657/75335/1/9780429442025_10.1201_9780429442025-11.pdf Taylor & Francis CRC Press 10.1201/9780429442025-11 10.1201/9780429442025-11 fa69b019-f4ee-4979-8d42-c6b6c476b5f0 Vitamin C Lotte and John Hecht Memorial Foundation a9bd203e-2329-457e-a93c-b053a8e62b88 9781138337992 9781032175256 CRC Press 27 open access |
| spellingShingle | Antioxidants, Ascorbic Acid, Infectious Disease, Intravenous Ascorbate, Vitamin C, acute sepsis, cancer treatment, infectious disease treatment, stem cell transplantation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Hoffer, Leonard John Chapter 11 Vitamin C and the Brain |
| title | Chapter 11 Vitamin C and the Brain |
| title_full | Chapter 11 Vitamin C and the Brain |
| title_fullStr | Chapter 11 Vitamin C and the Brain |
| title_full_unstemmed | Chapter 11 Vitamin C and the Brain |
| title_short | Chapter 11 Vitamin C and the Brain |
| title_sort | chapter 11 vitamin c and the brain |
| topic | Antioxidants, Ascorbic Acid, Infectious Disease, Intravenous Ascorbate, Vitamin C, acute sepsis, cancer treatment, infectious disease treatment, stem cell transplantation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Antioxidants, Ascorbic Acid, Infectious Disease, Intravenous Ascorbate, Vitamin C, acute sepsis, cancer treatment, infectious disease treatment, stem cell transplantation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | https://library.oapen.org/handle/20.500.12657/75335 |
| work_keys_str_mv | AT hofferleonardjohn chapter11vitamincandthebrain |