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Updates on Molecular Targeted Therapies for CNS Tumors

The challenges in identifying effective therapies for CNS tumors continue to be daunting. Potentially effective targeted therapies must be able to penetrate the blood–brain barrier to reach the tumor and, in sufficient concentrations, to result in meaningful treatment responses. Moreover, molecular...

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Gorde:
Formatua: Online
Hizkuntza:ingelesa
Argitaratua: MDPI - Multidisciplinary Digital Publishing Institute 2023
Gaiak:
glioblastoma molecular classification
ERK/MAPK pathway
PI3K/PTEN pathway
receptor tyrosine kinase
EGFR
PDGFRA
FGFR3
MET
EPHB2
NF1
immunotherapy
glioblastoma
blood–brain barrier
central nervous system
T cells
T lymphocytes
PCNSL
CNS lymphoma
methotrexate
novel therapies
novel therapeutics
neurofibromatosis
low grade glioma
plexiform neurofibroma
vestibular schwannoma
glioma
tumor mutation burden
neoantigen
immune score
germline mutation
antigen processing and presentation
ependymoma
subependymoma
RELA
YAP1
ZFTA
PFA
PFB
MYCN
Group A
Group B
myxopapillary
targeted therapy
diffuse midline gliomas
molecular targets
potential therapy development
intraparenchymal metastases
CNS disease
metastatic disease
tyrosine kinase inhibitors
monoclonal antibodies
Warburg effect
mass spectrometry
isotope labeling
cancer metabolism
pediatric brain tumor
adenosine
tumor microenvironment
A2AAR antagonist
immune evasion
adenosine receptors
bevacizumab
temozolomide
progression
biomarker
neoplastic
meningitis
leptomeningeal
chemotherapy
radiotherapy
intrathecal
GBM
U87MG
A172
Metformin
LPS
antioxidant
cell cycle arrest
apoptosis
low-grade glioma
preclinical models
IDH-mutant glioma
patient avatars
methylation
methylomics
G-CIMP
MGMT
DNMT
ATRX
H3K27M
CpG island
tumor suppressor
methyltransferases
histone acetylation
brain tumor
brain metastasis
lung cancer
lung malignancy
progression-free survival
epidermal growth factor receptor
lung carcinoma
molecular therapy
whole-brain radiation therapy
stereotactic radiosurgery
KIF11
n/a
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
Sarrera elektronikoa:ONIX_20230911_9783036585284_97
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