Translational and Comparative Research on Innovative Anti-Cancer Therapies
Cancer represents a major global challenge for medical practice in humans and companion animals. A plethora of basic and preclinical studies involving cell cultures and animal models have screened novel anti-cancer drugs and innovative treatments such as immunotherapy and gene-based therapy. In addi...
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| 格式: | Online |
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| 語言: | 英语 |
| 出版: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
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| 主題: | |
| 在線閱讀: | ONIX_20240514_9783039286171_74 |
| 標簽: |
沒有標簽, 成為第一個標記此記錄!
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| _version_ | 1869514622389714944 |
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| collection | Directory of Open Access Books |
| description | Cancer represents a major global challenge for medical practice in humans and companion animals. A plethora of basic and preclinical studies involving cell cultures and animal models have screened novel anti-cancer drugs and innovative treatments such as immunotherapy and gene-based therapy. In addition, emerging alternative translational models based on comparative oncology have shown promising results in anti-cancer drug discovery since companion animals develop spontaneous tumors and share the same environment as humans. Nonetheless, some gaps still exist in pre-clinical and clinical comparative animal models in terms of biological behavior, genetics, molecular pathways, as well as the immunological features of cancer that should be fulfilled to enhance their translational value. This Special Issue of Cancers contributes high-quality scientific evidence through novel data from preclinical and clinical studies performed in humans and/or animals. Thus, we hope that this set of articles will increase readers’ knowledge within the scope of comparative and translational oncology and encourage further research into these innovative anti-cancer therapies. |
| format | Online |
| id | doab-20.500.12854ir-137472 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1374722024-05-14T13:11:27Z Translational and Comparative Research on Innovative Anti-Cancer Therapies Queiroga, Felisbina Cogliati, Bruno cancer dog therapy quality of life viral RNA breast cancer valproic acid (VPA) histone deacetylase inhibitor (HDI) histone acetylation histone deacetylases (HDACs) epigenetics targeted therapy head and neck squamous cell carcinoma oral cancer oropharyngeal cancer laryngeal cancer miRNA novel therapeutic strategy safe anticancer treatment anaplastic thyroid cancer recurrent thyroid cancer effective treatment LEKTI SPINK5 KLK5 OSCC matriptase circulating tumor DNA (ctDNA) liquid biopsy next generation sequencing (NGS) gene variant hepatocarcinogenesis liver cancer animal model cell culture gene mutation epigenetic alteration translational research canine model comparative oncology MALDI imaging tumor progression liposomes Bleosome Bodipy-FL topical chemotherapy skin penetration colorectal cancer folic acid genomic stability DNA methylation gene expression nervous system cancer hallmarks tumor innervation neurotumoral communication immunity neuromodulation n/a thema EDItEUR::M Medicine and Nursing Cancer represents a major global challenge for medical practice in humans and companion animals. A plethora of basic and preclinical studies involving cell cultures and animal models have screened novel anti-cancer drugs and innovative treatments such as immunotherapy and gene-based therapy. In addition, emerging alternative translational models based on comparative oncology have shown promising results in anti-cancer drug discovery since companion animals develop spontaneous tumors and share the same environment as humans. Nonetheless, some gaps still exist in pre-clinical and clinical comparative animal models in terms of biological behavior, genetics, molecular pathways, as well as the immunological features of cancer that should be fulfilled to enhance their translational value. This Special Issue of Cancers contributes high-quality scientific evidence through novel data from preclinical and clinical studies performed in humans and/or animals. Thus, we hope that this set of articles will increase readers’ knowledge within the scope of comparative and translational oncology and encourage further research into these innovative anti-cancer therapies. 2024-05-14T13:11:18Z 2024-05-14T13:11:18Z 2024 book ONIX_20240514_9783039286171_74 9783039286171 9783039286188 https://directory.doabooks.org/handle/20.500.12854/137472 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/8629 https://mdpi.com/books/pdfview/book/8629 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-618-8 10.3390/books978-3-03928-618-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039286171 9783039286188 254 open access |
| spellingShingle | cancer dog therapy quality of life viral RNA breast cancer valproic acid (VPA) histone deacetylase inhibitor (HDI) histone acetylation histone deacetylases (HDACs) epigenetics targeted therapy head and neck squamous cell carcinoma oral cancer oropharyngeal cancer laryngeal cancer miRNA novel therapeutic strategy safe anticancer treatment anaplastic thyroid cancer recurrent thyroid cancer effective treatment LEKTI SPINK5 KLK5 OSCC matriptase circulating tumor DNA (ctDNA) liquid biopsy next generation sequencing (NGS) gene variant hepatocarcinogenesis liver cancer animal model cell culture gene mutation epigenetic alteration translational research canine model comparative oncology MALDI imaging tumor progression liposomes Bleosome Bodipy-FL topical chemotherapy skin penetration colorectal cancer folic acid genomic stability DNA methylation gene expression nervous system cancer hallmarks tumor innervation neurotumoral communication immunity neuromodulation n/a thema EDItEUR::M Medicine and Nursing Translational and Comparative Research on Innovative Anti-Cancer Therapies |
| title | Translational and Comparative Research on Innovative Anti-Cancer Therapies |
| title_full | Translational and Comparative Research on Innovative Anti-Cancer Therapies |
| title_fullStr | Translational and Comparative Research on Innovative Anti-Cancer Therapies |
| title_full_unstemmed | Translational and Comparative Research on Innovative Anti-Cancer Therapies |
| title_short | Translational and Comparative Research on Innovative Anti-Cancer Therapies |
| title_sort | translational and comparative research on innovative anti cancer therapies |
| topic | cancer dog therapy quality of life viral RNA breast cancer valproic acid (VPA) histone deacetylase inhibitor (HDI) histone acetylation histone deacetylases (HDACs) epigenetics targeted therapy head and neck squamous cell carcinoma oral cancer oropharyngeal cancer laryngeal cancer miRNA novel therapeutic strategy safe anticancer treatment anaplastic thyroid cancer recurrent thyroid cancer effective treatment LEKTI SPINK5 KLK5 OSCC matriptase circulating tumor DNA (ctDNA) liquid biopsy next generation sequencing (NGS) gene variant hepatocarcinogenesis liver cancer animal model cell culture gene mutation epigenetic alteration translational research canine model comparative oncology MALDI imaging tumor progression liposomes Bleosome Bodipy-FL topical chemotherapy skin penetration colorectal cancer folic acid genomic stability DNA methylation gene expression nervous system cancer hallmarks tumor innervation neurotumoral communication immunity neuromodulation n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | cancer dog therapy quality of life viral RNA breast cancer valproic acid (VPA) histone deacetylase inhibitor (HDI) histone acetylation histone deacetylases (HDACs) epigenetics targeted therapy head and neck squamous cell carcinoma oral cancer oropharyngeal cancer laryngeal cancer miRNA novel therapeutic strategy safe anticancer treatment anaplastic thyroid cancer recurrent thyroid cancer effective treatment LEKTI SPINK5 KLK5 OSCC matriptase circulating tumor DNA (ctDNA) liquid biopsy next generation sequencing (NGS) gene variant hepatocarcinogenesis liver cancer animal model cell culture gene mutation epigenetic alteration translational research canine model comparative oncology MALDI imaging tumor progression liposomes Bleosome Bodipy-FL topical chemotherapy skin penetration colorectal cancer folic acid genomic stability DNA methylation gene expression nervous system cancer hallmarks tumor innervation neurotumoral communication immunity neuromodulation n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20240514_9783039286171_74 |