Carbohydrate-Based Drugs Discovery

Carbohydrates play an essential role in the organism and have many bioactivities. Carbohydrate-based drug discovery is an up-and-coming area of research in medicinal chemistry. Bioactive carbohydrates open up a new source for drug development. More than 170 carbohydrate-based drugs have been success...

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Bibliographic Details
Format:	Online
Language:	English
Published:	MDPI - Multidisciplinary Digital Publishing Institute 2024
Subjects:	hepatocellular carcinoma metastasis ASGPR gene therapy VEGF/VEGFR2 signaling pathway breastfeeding women saliva sialic acids (Sia) avian influenza virus (AIV) glycoprotein resin glycosides macrocyclic natural glycolipids ring-opened analogues cytotoxicity protein translocation Sec61 translocon molecular docking LFG-Na sea cucumber Holothuria fuscopunctata molecular weight HPSEC-MALLS-RID bioactivity assay quality control rhamnose deoxythymidinediphosphate-L-rhamnose guanosine diphosphate rhamnose uridine diphosphate-rhamnose rhamnosyltransferase rhamnose biosynthesis iminosugar pyrrolidine multivalent effect glucosidase inhibitors osteoarthritis hyaluronic acid hyaluronic acid oligosaccharide derivatives ATDC5 lipopolysaccharide active ingredients polysaccharide purification glucan mannan immunomodulator heparin applications of heparin challenges of heparin therapy glycosylation Ferrier rearrangement perfluorinated solvent high stereoselectivity reusability aryl-C-glycoside novel structures bioactivity synthesis antibiotic aminoglycoside structural modification structure–activity relationship functional oligosaccharides gut microbiota intestinal barriers intestinal diseases 2-deoxythioglycosides silver triflate stereoselective synthesis glycals anticancer polysaccharides drug delivery systems nanomedicines proteins erythropoietin monoclonal antibodies amino alcohols 3-aminosugars sulfamidates deprotection Kukhtin–Ramirez reaction tumor-associated carbohydrate antigens KH-1 fluoro-modification tumor vaccine thema EDItEUR::J Society and Social Sciences::JM Psychology::JMA Psychological theory, systems, schools and viewpoints
Online Access:	ONIX_20240514_9783725804320_381
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Summary:	Carbohydrates play an essential role in the organism and have many bioactivities. Carbohydrate-based drug discovery is an up-and-coming area of research in medicinal chemistry. Bioactive carbohydrates open up a new source for drug development. More than 170 carbohydrate-based drugs have been successfully approved as anticoagulants, antitumor agents, antidiabetic agents, antibiotics, antiviral agents, and vaccines. However, most carbohydrates have low druggability. As such, new methods and strategies to improve carbohydrates’ druggability are in high demand.This Special Issue aimed to serve as an open forum where researchers can share their experiences and findings on carbohydrate-based drugs, with a focus on the discovery and development of new carbohydrate-based therapeutic agents. Contributions to this issue, in the form of both original research and review articles, cover the separation, identification, synthesis, and pharmacology of bioactive carbohydrates, including monosaccharides, oligosaccharides, polysaccharides, glycopeptides, glycoproteins, glycomimetics, and others.

Carbohydrate-Based Drugs Discovery

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