Recent Advances in Secondary Processing of Pharmaceutical Powders
Pharmaceuticals are becoming increasingly important in modern society. In most cases, active pharmaceutical ingredients (APIs) are formed through crystallisation but need to be combined with excipients to form a tablet, or with carriers to form an oral suspension. The formation of tablets requires s...
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| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Länkar: | ONIX_20240514_9783725806782_427 |
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| collection | Directory of Open Access Books |
| description | Pharmaceuticals are becoming increasingly important in modern society. In most cases, active pharmaceutical ingredients (APIs) are formed through crystallisation but need to be combined with excipients to form a tablet, or with carriers to form an oral suspension. The formation of tablets requires several secondary processing steps, such as milling of the API and mixing with excipients (often involving granulation) before finally being tabletted. Due to the differences in physical and mechanical properties that individual APIs and excipients exhibit, these secondary processing steps are often fraught with challenges. This Special Issue comprises 11 research articles and 1 review which outline the recent advances in secondary processing of pharmaceutical powders, and aims to enhance our understanding of powder behaviour and help us tackle these challenges. Through careful experimentation and the application of sophisticated computational techniques, the authors of these papers demonstrate advances in our understanding of many of the processing steps for pharmaceutical products. With this Special Issue, I hope to engage a broad readership in order to spark new ideas to further advance our knowledge of powder processing and to optimise production. |
| format | Online |
| id | doab-20.500.12854ir-137831 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1378312024-05-14T14:37:54Z Recent Advances in Secondary Processing of Pharmaceutical Powders Hare, Colin spiral jet mills discrete element models computational fluid dynamics agent-based modeling and simulation process modeling and simulation tableting product structures and characteristics powder flow die filling powder rheology dynamic cohesive index excipients continuous manufacturing quality by design mixing coating magnesium stearate lubricant Turbula ProCepT Mechanofusion flowability rheometry flow energy wet granulation multicomponent population balance model content uniformity powder agglomeration Discrete Element Method cohesion twin-screw granulation continuous mixing technology vertical blender direct compression lubrication material characterization CFD-DEM simulation wet particles capillary force viscous force fluidized bed rotor granulator pharmaceutical manufacturing peptides crystallization powder mixing amorphous solid dispersions spray drying L-leucine bulk powder characterization particle engineering flowability enhancement surface modification continuous direct compression (CDC) powder cohesion loss in weight (LIW) feeding blending tabletting continuous manufacture triboelectric charging electrostatics DPI DEM inhalation carrier-based formulation thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Pharmaceuticals are becoming increasingly important in modern society. In most cases, active pharmaceutical ingredients (APIs) are formed through crystallisation but need to be combined with excipients to form a tablet, or with carriers to form an oral suspension. The formation of tablets requires several secondary processing steps, such as milling of the API and mixing with excipients (often involving granulation) before finally being tabletted. Due to the differences in physical and mechanical properties that individual APIs and excipients exhibit, these secondary processing steps are often fraught with challenges. This Special Issue comprises 11 research articles and 1 review which outline the recent advances in secondary processing of pharmaceutical powders, and aims to enhance our understanding of powder behaviour and help us tackle these challenges. Through careful experimentation and the application of sophisticated computational techniques, the authors of these papers demonstrate advances in our understanding of many of the processing steps for pharmaceutical products. With this Special Issue, I hope to engage a broad readership in order to spark new ideas to further advance our knowledge of powder processing and to optimise production. 2024-05-14T14:37:37Z 2024-05-14T14:37:37Z 2024 book ONIX_20240514_9783725806782_427 9783725806782 9783725806775 https://directory.doabooks.org/handle/20.500.12854/137831 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/9069 https://mdpi.com/books/pdfview/book/9069 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-0677-5 10.3390/books978-3-7258-0677-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725806782 9783725806775 278 open access |
| spellingShingle | spiral jet mills discrete element models computational fluid dynamics agent-based modeling and simulation process modeling and simulation tableting product structures and characteristics powder flow die filling powder rheology dynamic cohesive index excipients continuous manufacturing quality by design mixing coating magnesium stearate lubricant Turbula ProCepT Mechanofusion flowability rheometry flow energy wet granulation multicomponent population balance model content uniformity powder agglomeration Discrete Element Method cohesion twin-screw granulation continuous mixing technology vertical blender direct compression lubrication material characterization CFD-DEM simulation wet particles capillary force viscous force fluidized bed rotor granulator pharmaceutical manufacturing peptides crystallization powder mixing amorphous solid dispersions spray drying L-leucine bulk powder characterization particle engineering flowability enhancement surface modification continuous direct compression (CDC) powder cohesion loss in weight (LIW) feeding blending tabletting continuous manufacture triboelectric charging electrostatics DPI DEM inhalation carrier-based formulation thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Recent Advances in Secondary Processing of Pharmaceutical Powders |
| title | Recent Advances in Secondary Processing of Pharmaceutical Powders |
| title_full | Recent Advances in Secondary Processing of Pharmaceutical Powders |
| title_fullStr | Recent Advances in Secondary Processing of Pharmaceutical Powders |
| title_full_unstemmed | Recent Advances in Secondary Processing of Pharmaceutical Powders |
| title_short | Recent Advances in Secondary Processing of Pharmaceutical Powders |
| title_sort | recent advances in secondary processing of pharmaceutical powders |
| topic | spiral jet mills discrete element models computational fluid dynamics agent-based modeling and simulation process modeling and simulation tableting product structures and characteristics powder flow die filling powder rheology dynamic cohesive index excipients continuous manufacturing quality by design mixing coating magnesium stearate lubricant Turbula ProCepT Mechanofusion flowability rheometry flow energy wet granulation multicomponent population balance model content uniformity powder agglomeration Discrete Element Method cohesion twin-screw granulation continuous mixing technology vertical blender direct compression lubrication material characterization CFD-DEM simulation wet particles capillary force viscous force fluidized bed rotor granulator pharmaceutical manufacturing peptides crystallization powder mixing amorphous solid dispersions spray drying L-leucine bulk powder characterization particle engineering flowability enhancement surface modification continuous direct compression (CDC) powder cohesion loss in weight (LIW) feeding blending tabletting continuous manufacture triboelectric charging electrostatics DPI DEM inhalation carrier-based formulation thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| topic_facet | spiral jet mills discrete element models computational fluid dynamics agent-based modeling and simulation process modeling and simulation tableting product structures and characteristics powder flow die filling powder rheology dynamic cohesive index excipients continuous manufacturing quality by design mixing coating magnesium stearate lubricant Turbula ProCepT Mechanofusion flowability rheometry flow energy wet granulation multicomponent population balance model content uniformity powder agglomeration Discrete Element Method cohesion twin-screw granulation continuous mixing technology vertical blender direct compression lubrication material characterization CFD-DEM simulation wet particles capillary force viscous force fluidized bed rotor granulator pharmaceutical manufacturing peptides crystallization powder mixing amorphous solid dispersions spray drying L-leucine bulk powder characterization particle engineering flowability enhancement surface modification continuous direct compression (CDC) powder cohesion loss in weight (LIW) feeding blending tabletting continuous manufacture triboelectric charging electrostatics DPI DEM inhalation carrier-based formulation thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| url | ONIX_20240514_9783725806782_427 |