What SARS-CoV-2 Variants Have Taught Us: Evolutionary Challenges of RNA Viruses

RNA viruses have a rapid pace of evolutionary change. Mutations in RNA viral genomes occur at a pace that greatly exceeds that observed in other organisms and determine much of their evolutionary “behavior”. For instance, RNA viruses have a great ability to cross species barriers and, hence, emergin...

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Opis bibliograficzny
Format:	Online
Język:	angielski
Wydane:	MDPI - Multidisciplinary Digital Publishing Institute 2024
Hasła przedmiotowe:	COVID-19 Omicron sub-lineages Ecuador SARS-CoV-2 variants pseudovirus neutralization assay convalescent plasma SARS-CoV-2 chicken passive immunization antibodies neutralizing antibodies egg BA.2 BA.5 symptoms Germany impact variant of concern phylogenetic analysis nucleocapsid protein localization antibody therapy severe acute respiratory syndrome coronavirus 2 high-resolution melting Omicron subvariant F486V mutation evolution receptor binding domain T-cell epitope spike protein drug B.1.620 R.1 cell entry neutralization antibody evasion ACE2 binding molecular modeling mutation analysis nucleotide diversity RNA secondary structure VOCs variants infection control spike protein RBD heparin pentosan polysulfate mucopolysaccharide polysulfate omicron delta immunocompromised host hospitalization RNA virus quasispecies mutation recombination coronavirus virus adaptation persistent infection N-terminal domain LRRC15 leucine rich repeat containing 15 neuropilin-1 NRP-1 mutations RNA viruses host immunity adaptation viral escape Omicron: sub-lineages transmission and infection disease severity peptide microarray humoral immunity IgA IgG epitope mapping SARS-CoV-2 variant pandemic vaccine antiviral HIV-1 MERS-CoV monkeypox virus influenza virus lipid raft ganglioside electrostatic surface potential South America dynamics BA.1 BA.4 vaccines booster vaccines doses effectiveness COVID-19-related disease SARS CoV-2 antibody VOC RT-qPCR surveillance n/a thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics
Dostęp online:	ONIX_20240514_9783036598314_456
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Opis
Streszczenie:	RNA viruses have a rapid pace of evolutionary change. Mutations in RNA viral genomes occur at a pace that greatly exceeds that observed in other organisms and determine much of their evolutionary “behavior”. For instance, RNA viruses have a great ability to cross species barriers and, hence, emerging new human and animal viruses. Indeed, emerging RNA viruses are currently the biggest health threat to humankind to emerge in a very long time. Thus, it is crucial at this time to shed some light on how the evolutionary behavior of RNA viruses shapes their epidemiolocal, fitness, and pathological features. This will contribute toward a better understanding of how to deal with these threats.

What SARS-CoV-2 Variants Have Taught Us: Evolutionary Challenges of RNA Viruses

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