Cancer Prevention with Molecular Target Therapies 4.0
Personalized medicine is playing an important role in cancer prevention. To date, it is clear that many cancers are molecularly distinct subtypes, and different therapeutic approaches are required for each. Indeed, the identification of cancer susceptibility genes permits identifying patients “at ri...
Uloženo v:
| Médium: | Online |
|---|---|
| Jazyk: | angličtina |
| Vydáno: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
|
| Témata: | |
| On-line přístup: | ONIX_20250220_9783725819522_49 |
| Tagy: |
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| _version_ | 1869522543485911040 |
|---|---|
| collection | Directory of Open Access Books |
| description | Personalized medicine is playing an important role in cancer prevention. To date, it is clear that many cancers are molecularly distinct subtypes, and different therapeutic approaches are required for each. Indeed, the identification of cancer susceptibility genes permits identifying patients “at risk” of developing neoplasia and supports modifying individual risk behaviors or the choice of preventive therapy. Additionally, the efficacy of various targeted therapies in different cancer subtypes suggests that treatment choices in the near future will be increasingly centered on molecular signatures. Data from preclinical, clinical and observational studies have revealed the ability to prevent cancer development for compounds with different indications than cancer. The concept of drug repurposing permits combinations that can target several critical pathways of a specific disease, decreasing the risk of resistance observed when using single-agent targeted therapy. This open access Special Issue collates original research and review articles on molecular oncology, with an emphasis on the early detection and prevention of cancer. It highlights new findings, methods and technical advances in molecular cancer research. |
| format | Online |
| id | doab-20.500.12854ir-152685 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1526852025-02-20T12:54:36Z Cancer Prevention with Molecular Target Therapies 4.0 Paleari, Laura RNA-binding protein 3 (RBMS3) carcinogenesis cancer prevention target discovery target therapy epithelial–mesenchymal transition (EMT) Myc kinases PLK1 Aurora-A Aurora-B GSK-3 PKA PIM BRD4 kinase inhibitors living donor liver transplantation hepatocellular carcinoma graft-to-recipient weight ratio graft size tumor recurrence CAFs primary culture CAF markers patient-specific aggressive CAFs post-surgery event drug resistance endometrial cancers endothelial adhesion biomechanics mechanobiology fluid shear stress brain metastasis biomarkers gastric cancer DNA-based markers chemokines MMPs TIMPs novel biomarker pancreatic cancer KRAS KRAS inhibitors KRAS-dependency resistance escaping endometrial cancer fertility preservation molecular characterization reproductive outcome immune checkpoint inhibitor head and neck cancers head and neck squamous cell carcinoma neutrophil extracellular traps Th17 Treg differentiation colorectal cancer evolution HTLV-1 adult T-cell leukemia viral oncogenesis Tax HBZ apoptosis n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology thema EDItEUR::A The Arts::AV Music Personalized medicine is playing an important role in cancer prevention. To date, it is clear that many cancers are molecularly distinct subtypes, and different therapeutic approaches are required for each. Indeed, the identification of cancer susceptibility genes permits identifying patients “at risk” of developing neoplasia and supports modifying individual risk behaviors or the choice of preventive therapy. Additionally, the efficacy of various targeted therapies in different cancer subtypes suggests that treatment choices in the near future will be increasingly centered on molecular signatures. Data from preclinical, clinical and observational studies have revealed the ability to prevent cancer development for compounds with different indications than cancer. The concept of drug repurposing permits combinations that can target several critical pathways of a specific disease, decreasing the risk of resistance observed when using single-agent targeted therapy. This open access Special Issue collates original research and review articles on molecular oncology, with an emphasis on the early detection and prevention of cancer. It highlights new findings, methods and technical advances in molecular cancer research. 2025-02-20T12:54:33Z 2025-02-20T12:54:33Z 2024 book ONIX_20250220_9783725819522_49 9783725819522 9783725819515 https://directory.doabooks.org/handle/20.500.12854/152685 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/9805 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-1951-5 10.3390/books978-3-7258-1951-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725819522 9783725819515 230 Basel open access |
| spellingShingle | RNA-binding protein 3 (RBMS3) carcinogenesis cancer prevention target discovery target therapy epithelial–mesenchymal transition (EMT) Myc kinases PLK1 Aurora-A Aurora-B GSK-3 PKA PIM BRD4 kinase inhibitors living donor liver transplantation hepatocellular carcinoma graft-to-recipient weight ratio graft size tumor recurrence CAFs primary culture CAF markers patient-specific aggressive CAFs post-surgery event drug resistance endometrial cancers endothelial adhesion biomechanics mechanobiology fluid shear stress brain metastasis biomarkers gastric cancer DNA-based markers chemokines MMPs TIMPs novel biomarker pancreatic cancer KRAS KRAS inhibitors KRAS-dependency resistance escaping endometrial cancer fertility preservation molecular characterization reproductive outcome immune checkpoint inhibitor head and neck cancers head and neck squamous cell carcinoma neutrophil extracellular traps Th17 Treg differentiation colorectal cancer evolution HTLV-1 adult T-cell leukemia viral oncogenesis Tax HBZ apoptosis n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology thema EDItEUR::A The Arts::AV Music Cancer Prevention with Molecular Target Therapies 4.0 |
| title | Cancer Prevention with Molecular Target Therapies 4.0 |
| title_full | Cancer Prevention with Molecular Target Therapies 4.0 |
| title_fullStr | Cancer Prevention with Molecular Target Therapies 4.0 |
| title_full_unstemmed | Cancer Prevention with Molecular Target Therapies 4.0 |
| title_short | Cancer Prevention with Molecular Target Therapies 4.0 |
| title_sort | cancer prevention with molecular target therapies 4 0 |
| topic | RNA-binding protein 3 (RBMS3) carcinogenesis cancer prevention target discovery target therapy epithelial–mesenchymal transition (EMT) Myc kinases PLK1 Aurora-A Aurora-B GSK-3 PKA PIM BRD4 kinase inhibitors living donor liver transplantation hepatocellular carcinoma graft-to-recipient weight ratio graft size tumor recurrence CAFs primary culture CAF markers patient-specific aggressive CAFs post-surgery event drug resistance endometrial cancers endothelial adhesion biomechanics mechanobiology fluid shear stress brain metastasis biomarkers gastric cancer DNA-based markers chemokines MMPs TIMPs novel biomarker pancreatic cancer KRAS KRAS inhibitors KRAS-dependency resistance escaping endometrial cancer fertility preservation molecular characterization reproductive outcome immune checkpoint inhibitor head and neck cancers head and neck squamous cell carcinoma neutrophil extracellular traps Th17 Treg differentiation colorectal cancer evolution HTLV-1 adult T-cell leukemia viral oncogenesis Tax HBZ apoptosis n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology thema EDItEUR::A The Arts::AV Music |
| topic_facet | RNA-binding protein 3 (RBMS3) carcinogenesis cancer prevention target discovery target therapy epithelial–mesenchymal transition (EMT) Myc kinases PLK1 Aurora-A Aurora-B GSK-3 PKA PIM BRD4 kinase inhibitors living donor liver transplantation hepatocellular carcinoma graft-to-recipient weight ratio graft size tumor recurrence CAFs primary culture CAF markers patient-specific aggressive CAFs post-surgery event drug resistance endometrial cancers endothelial adhesion biomechanics mechanobiology fluid shear stress brain metastasis biomarkers gastric cancer DNA-based markers chemokines MMPs TIMPs novel biomarker pancreatic cancer KRAS KRAS inhibitors KRAS-dependency resistance escaping endometrial cancer fertility preservation molecular characterization reproductive outcome immune checkpoint inhibitor head and neck cancers head and neck squamous cell carcinoma neutrophil extracellular traps Th17 Treg differentiation colorectal cancer evolution HTLV-1 adult T-cell leukemia viral oncogenesis Tax HBZ apoptosis n/a thema EDItEUR::A The Arts::AT Performing arts::ATD Theatre studies thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology thema EDItEUR::A The Arts::AV Music |
| url | ONIX_20250220_9783725819522_49 |