Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles

The purpose of this reprint is to introduce the reader to the latest advances in the chemistry of N-heterocycles, such as the synthesis, reactivity, and applications of aromatic and saturated nitrogen heterocyclic compounds. The role of N-heterocycles in human life is difficult to overestimate; thei...

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Bibliographic Details
Format:	Online
Language:	English
Published:	MDPI - Multidisciplinary Digital Publishing Institute 2025
Subjects:	C–H functionalization cyclization indazole products transition metals catalysis nitro compounds Azolo[1,5-a]pyrimidines CK2 inhibition antitumor activity multicomponent reaction amides BF3·Et2O debenzylation nitrogen heterocycles 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate anthranilamide ethyl levulinate Amberlyst® 15 Brønsted acid cascade reaction mechanochemistry quinazolinone ball mill azirines pyrrolines cycloaddition annulation copper catalysis nitro group nitropyridines bis-(het)aryl ethenes nucleophilic substitution thiols UV–Vis spectroscopy alkoxides aziridination manganese iminoiodinane energetic materials tetrazine hydroxytetrazole oxadiazole sulfonylureas DPP-IV inhibitors diabetes mellitus peptidomimetics alkynes enediynes heterocycles benzo[b]thiophene Bergman cyclization Nicholas reaction Sonogashira coupling benzenesulfonamides antifolates folic acids synthesis applications drugs aziridine non-activated nucleophilic ring-opening regioselectivity pyrrole domino reaction 1H-indole synthesis aza–Michael reaction SNAr reaction heteroaromatization 4-hydroxy-2-pyrone 4-pyridone aminoenone trifluoromethylated heterocycles regioselective reactions oxidative cyclization manganese(IV) oxide 1,2,4-triazine phenols cross-coupling spiropyrrolidine derivatives antimicrobial antioxidant antidiabetic ADME molecular docking and dynamic simulation sulfur–nitrogen heterocycles benzo[1,2-d:4,5-d’]bis([1,2,3]thiadiazole) aromatic nucleophilic substitution Suzuki and Stille cross-coupling reactions X-ray analysis estradiol benzisoxazole hybrid cancer selectivity apoptosis induction carborane tetrazole HEMDs DFT single crystal X-ray diffraction electrochemistry imidazoles vinyl azides click chemistry mechanochemical synthesis 1,2,3-triazole cycloaddition reaction Rufinamide synthesis solvent-free C-glycosyl compound amidrazone IEDDA pyridine aminofurazans fused furazans perchlorates energetic compound impact sensitivity thermal decomposition combustion burning rate 1,2,3-triazoles nucleobases Lewis acid molecular docking donor–acceptor cyclopropanes primary amines pyrrolidin-2-ones benz[g]indolizidines acetylenes amino acids C-H activation catalysis isoquinolones active methylene thioamides Michael addition dithiomalondianilide cyanoacetic esters [1,2]dithiolo[3,4-b]pyridines herbicide safeners azomethine ylide pyrrolidine spiro-compound imidazole medicinal chemistry drug discovery Minisci reaction heterogeneous photocatalysis N-hydroxyphthalimide titanium dioxide green chemistry visible light photocatalysis 2-hydroxyphenyl group hydrogen bond ESIPT luminescence [1,2,4]triazolo[4,3-c]quinazolines fluorescence solvatochromism pH-sensor multicomponent domino cyclizations ethyl trifluoropyruvate methyl ketones amino alcohols γ-lactams tetrahydropyrrolo[2,1-b]oxazolones tetrahydropyrrolo[2,1-b]oxazinones alkaloid Maillard reaction crystallization-induced diastereomer transformation glutamine hydroxy amino acid diketopiperazine thiourea dioxide TDO pyridazine pyrimidine pyrazine organophosphorus compounds dipyrroloquinoxaline bathochromic shift substituent effect energy gap N-trifluoromethyl group imidates iminonitriles nitrostyrenes 2-aminopyridine N-heterocycles 1,3,4-oxadiazole D-ribose L-amino acid pyrrole-2-carbaldehyde iodine effect antibacterial activity sustainable synthesis aromatic N-heterocycles solid acids nanoparticles microwaves ultrasounds visible light activation high hydrostatic pressure biomass 1,3-diynamides ynamides homogeneous catalysis annulation reactions cycloaddition cascade reactions helical twisted frontier molecular orbitals (Hel-FMO) Hexa-dehydro-Diels–Alder (HDDA) reaction quinolines indoles carbazoles N-heterocyclic-based dyes photosensitizers photodynamic therapy thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat
Online Access:	ONIX_20250220_9783725820818_103
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Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles

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