Molecular Targets of Oxidative Stress
Oxidative stress, known to increase the risk of multiple metabolic and chronic disorders or cancer development, is defined as an imbalance between the production of reactive oxygen species (ROS) and the capacity of antioxidants to counteract the deleterious effects of oxidants. To regulate the oxida...
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| Idioma: | anglès |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Accés en línia: | ONIX_20250220_9783725822270_172 |
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| description | Oxidative stress, known to increase the risk of multiple metabolic and chronic disorders or cancer development, is defined as an imbalance between the production of reactive oxygen species (ROS) and the capacity of antioxidants to counteract the deleterious effects of oxidants. To regulate the oxidation/reduction (redox) balance, numerous antioxidant enzymes and nonenzymatic antioxidants exist. Free radicals activate transcription factors to promote antioxidant production and mitochondrial biogenesis. One of these transcription factors, nuclear factor erythroid 2-related factor 2 (Nrf2), is a master regulator of antioxidant and anti-inflammatory responses. Indeed, Nrf2 contributes to redox balance by initiating the transcription of hundreds of genes involved in antioxidant and cytoprotective responses. A better understanding of the molecular targets of oxidative stress and their interaction with the Nrf2 signaling pathway would strengthen the relevance of their preventive or therapeutic use in health and diseases. Most of the studies presented in this Special Issue were dedicated to multiple metabolic and chronic disorders or cancer development. They contribute to improving our understanding of the molecular targets of oxidative stress and their interaction with the Nrf2 signaling pathway in some oxidative-stress-related diseases. |
| format | Online |
| id | doab-20.500.12854ir-152808 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1528082025-02-20T13:06:19Z Molecular Targets of Oxidative Stress Bonay, Marcel ASCT2 glutamate-glutamine cycle glutaminase glutamine synthase glutathione synthetase iNOS S-nitrosylated cysteine xCT neurological manifestations long-COVID antioxidant enzymes glutathione transferases polymorphisms Nrf2 spinal cord injury phrenic motoneuron AMPK neuroinflammation antioxidant rat NRF2 amyotrophic lateral sclerosis C9orf72 dipeptide repeat proteins obesity lipid metabolism chronic inflammation oxidative stress glucoraphanin inflammatory bowel diseases DSS mitochondrial homeostasis skeletal muscle exercise proteomics radiation low dose-rate mesenchymal stem cells human microvascular endothelial cells RNAseq gene regulation Hsp90 ERK JNK Cdk5 Pin1 HO-1 phosphorylation acetylation ubiquitination intracellular degradation ligand-dependent stability cancer neurological disorders exosomes miRNA non-pigmented ciliary epithelium trabecular meshwork primary open-angle glaucoma Alzheimer’s disease antioxidant response electrophilic activators multitargeting compounds Nrf2 inducers protein–protein interaction inhibitors Parkinson’s disease depression Nuclear factor erythroid-2 (Nrf2) pathophysiology antioxidant pathways Haemoxygenase (HO-1) Nuclear factor kappa B (NF-κB) rutin UVA-induced damage Nrf2 pathway mitochondrial function thyroid hormones antioxidants cardioprotection THP-1-derived macrophages alveolar macrophages repetitive magnetic stimulation p38 MAPK p62 Nrf2 knockout mice Keap1 Staphylococcus aureus ferroptosis metabolism Ehretia tinifolia anti-inflammatory MAPK NF-κB n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Oxidative stress, known to increase the risk of multiple metabolic and chronic disorders or cancer development, is defined as an imbalance between the production of reactive oxygen species (ROS) and the capacity of antioxidants to counteract the deleterious effects of oxidants. To regulate the oxidation/reduction (redox) balance, numerous antioxidant enzymes and nonenzymatic antioxidants exist. Free radicals activate transcription factors to promote antioxidant production and mitochondrial biogenesis. One of these transcription factors, nuclear factor erythroid 2-related factor 2 (Nrf2), is a master regulator of antioxidant and anti-inflammatory responses. Indeed, Nrf2 contributes to redox balance by initiating the transcription of hundreds of genes involved in antioxidant and cytoprotective responses. A better understanding of the molecular targets of oxidative stress and their interaction with the Nrf2 signaling pathway would strengthen the relevance of their preventive or therapeutic use in health and diseases. Most of the studies presented in this Special Issue were dedicated to multiple metabolic and chronic disorders or cancer development. They contribute to improving our understanding of the molecular targets of oxidative stress and their interaction with the Nrf2 signaling pathway in some oxidative-stress-related diseases. 2025-02-20T13:06:17Z 2025-02-20T13:06:17Z 2024 book ONIX_20250220_9783725822270_172 9783725822270 9783725822287 https://directory.doabooks.org/handle/20.500.12854/152808 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10034 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2228-7 10.3390/books978-3-7258-2228-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725822270 9783725822287 360 Basel open access |
| spellingShingle | ASCT2 glutamate-glutamine cycle glutaminase glutamine synthase glutathione synthetase iNOS S-nitrosylated cysteine xCT neurological manifestations long-COVID antioxidant enzymes glutathione transferases polymorphisms Nrf2 spinal cord injury phrenic motoneuron AMPK neuroinflammation antioxidant rat NRF2 amyotrophic lateral sclerosis C9orf72 dipeptide repeat proteins obesity lipid metabolism chronic inflammation oxidative stress glucoraphanin inflammatory bowel diseases DSS mitochondrial homeostasis skeletal muscle exercise proteomics radiation low dose-rate mesenchymal stem cells human microvascular endothelial cells RNAseq gene regulation Hsp90 ERK JNK Cdk5 Pin1 HO-1 phosphorylation acetylation ubiquitination intracellular degradation ligand-dependent stability cancer neurological disorders exosomes miRNA non-pigmented ciliary epithelium trabecular meshwork primary open-angle glaucoma Alzheimer’s disease antioxidant response electrophilic activators multitargeting compounds Nrf2 inducers protein–protein interaction inhibitors Parkinson’s disease depression Nuclear factor erythroid-2 (Nrf2) pathophysiology antioxidant pathways Haemoxygenase (HO-1) Nuclear factor kappa B (NF-κB) rutin UVA-induced damage Nrf2 pathway mitochondrial function thyroid hormones antioxidants cardioprotection THP-1-derived macrophages alveolar macrophages repetitive magnetic stimulation p38 MAPK p62 Nrf2 knockout mice Keap1 Staphylococcus aureus ferroptosis metabolism Ehretia tinifolia anti-inflammatory MAPK NF-κB n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Molecular Targets of Oxidative Stress |
| title | Molecular Targets of Oxidative Stress |
| title_full | Molecular Targets of Oxidative Stress |
| title_fullStr | Molecular Targets of Oxidative Stress |
| title_full_unstemmed | Molecular Targets of Oxidative Stress |
| title_short | Molecular Targets of Oxidative Stress |
| title_sort | molecular targets of oxidative stress |
| topic | ASCT2 glutamate-glutamine cycle glutaminase glutamine synthase glutathione synthetase iNOS S-nitrosylated cysteine xCT neurological manifestations long-COVID antioxidant enzymes glutathione transferases polymorphisms Nrf2 spinal cord injury phrenic motoneuron AMPK neuroinflammation antioxidant rat NRF2 amyotrophic lateral sclerosis C9orf72 dipeptide repeat proteins obesity lipid metabolism chronic inflammation oxidative stress glucoraphanin inflammatory bowel diseases DSS mitochondrial homeostasis skeletal muscle exercise proteomics radiation low dose-rate mesenchymal stem cells human microvascular endothelial cells RNAseq gene regulation Hsp90 ERK JNK Cdk5 Pin1 HO-1 phosphorylation acetylation ubiquitination intracellular degradation ligand-dependent stability cancer neurological disorders exosomes miRNA non-pigmented ciliary epithelium trabecular meshwork primary open-angle glaucoma Alzheimer’s disease antioxidant response electrophilic activators multitargeting compounds Nrf2 inducers protein–protein interaction inhibitors Parkinson’s disease depression Nuclear factor erythroid-2 (Nrf2) pathophysiology antioxidant pathways Haemoxygenase (HO-1) Nuclear factor kappa B (NF-κB) rutin UVA-induced damage Nrf2 pathway mitochondrial function thyroid hormones antioxidants cardioprotection THP-1-derived macrophages alveolar macrophages repetitive magnetic stimulation p38 MAPK p62 Nrf2 knockout mice Keap1 Staphylococcus aureus ferroptosis metabolism Ehretia tinifolia anti-inflammatory MAPK NF-κB n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | ASCT2 glutamate-glutamine cycle glutaminase glutamine synthase glutathione synthetase iNOS S-nitrosylated cysteine xCT neurological manifestations long-COVID antioxidant enzymes glutathione transferases polymorphisms Nrf2 spinal cord injury phrenic motoneuron AMPK neuroinflammation antioxidant rat NRF2 amyotrophic lateral sclerosis C9orf72 dipeptide repeat proteins obesity lipid metabolism chronic inflammation oxidative stress glucoraphanin inflammatory bowel diseases DSS mitochondrial homeostasis skeletal muscle exercise proteomics radiation low dose-rate mesenchymal stem cells human microvascular endothelial cells RNAseq gene regulation Hsp90 ERK JNK Cdk5 Pin1 HO-1 phosphorylation acetylation ubiquitination intracellular degradation ligand-dependent stability cancer neurological disorders exosomes miRNA non-pigmented ciliary epithelium trabecular meshwork primary open-angle glaucoma Alzheimer’s disease antioxidant response electrophilic activators multitargeting compounds Nrf2 inducers protein–protein interaction inhibitors Parkinson’s disease depression Nuclear factor erythroid-2 (Nrf2) pathophysiology antioxidant pathways Haemoxygenase (HO-1) Nuclear factor kappa B (NF-κB) rutin UVA-induced damage Nrf2 pathway mitochondrial function thyroid hormones antioxidants cardioprotection THP-1-derived macrophages alveolar macrophages repetitive magnetic stimulation p38 MAPK p62 Nrf2 knockout mice Keap1 Staphylococcus aureus ferroptosis metabolism Ehretia tinifolia anti-inflammatory MAPK NF-κB n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20250220_9783725822270_172 |