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Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease

Drug delivery to the brain, restricted by the blood-brain barrier (BBB), remains one of the major obstacles in central nervous system (CNS) drug development. Solute carriers and ATP-binding cassette family (ABC) transporters expressed at the BBB play crucial roles in drug delivery to the brain. Know...

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Enregistré dans:
Format: Online
Langue:anglais
Publié: MDPI - Multidisciplinary Digital Publishing Institute 2025
Sujets:
amyotrophic lateral sclerosis
blood–brain barrier
brain microvascular endothelial cells
C9orf72 gene
proteomics
blood brain barrier
receptor-mediated transcytosis
low-density lipoprotein receptor family
low-density lipoprotein receptor-related protein 1
proprotein convertase subtilisin/kexin type 9
central nervous system drug delivery
therapeutic blood–brain barrier modification
metformin
ischemic stroke
repurposing
transporters
in vitro
BBB
co-culture
P-GP
Octs
permeability
ABC transporters
brain microvessels
peripheral tissues and vessels
gene expression patterns
RNA-seq
WesTM analysis
across species
choroid plexus
epithelial cell
lactate
monocarboxylate transporter
thyroid hormone
blood-brain barrier
P-glycoprotein
copper
bis(thiosemicarbazone)
CNS drug delivery
tight junction proteins
adenosine receptor signaling
adenosine receptor agonists
adenosine receptor antagonist
uptake transporters
pharmacokinetics
glucuronide
conjugate metabolite
uridine diphosphate-glucuronosyltransferase
organic anion-transporting polypeptide
BBB penetration
Kp,uu,brain prediction
MDR1
BCRP
ABCB1 knock-out
preclinical MDR1
species differences
MDR1 inhibitors
thema EDItEUR::M Medicine and Nursing
thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries
Accès en ligne:ONIX_20250220_9783725825066_306
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