Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease
Drug delivery to the brain, restricted by the blood-brain barrier (BBB), remains one of the major obstacles in central nervous system (CNS) drug development. Solute carriers and ATP-binding cassette family (ABC) transporters expressed at the BBB play crucial roles in drug delivery to the brain. Know...
Sábháilte in:
| Formáid: | Online |
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| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
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| Ábhair: | |
| Rochtain ar líne: | ONIX_20250220_9783725825066_306 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| _version_ | 1869520070439337984 |
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| collection | Directory of Open Access Books |
| description | Drug delivery to the brain, restricted by the blood-brain barrier (BBB), remains one of the major obstacles in central nervous system (CNS) drug development. Solute carriers and ATP-binding cassette family (ABC) transporters expressed at the BBB play crucial roles in drug delivery to the brain. Knowledge about brain transporters and the receptors expressed has opened up new opportunities for improving drug delivery to the brain and understanding the pathogenesis of CNS diseases. This Special Issue, entitled the “Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease”, aims to provide information about the latest developments in the field of transporter-mediated drug delivery to the brain, the roles of transporters and receptors in CNS diseases, as well as advances in the methodologies for the evaluation of carrier-mediated drug delivery to the brain. |
| format | Online |
| id | doab-20.500.12854ir-152942 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1529422025-02-20T13:19:14Z Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease Fricker, Gert Puris, Elena amyotrophic lateral sclerosis blood–brain barrier brain microvascular endothelial cells C9orf72 gene proteomics blood brain barrier receptor-mediated transcytosis low-density lipoprotein receptor family low-density lipoprotein receptor-related protein 1 proprotein convertase subtilisin/kexin type 9 central nervous system drug delivery therapeutic blood–brain barrier modification metformin ischemic stroke repurposing transporters in vitro BBB co-culture P-GP Octs permeability ABC transporters brain microvessels peripheral tissues and vessels gene expression patterns RNA-seq WesTM analysis across species choroid plexus epithelial cell lactate monocarboxylate transporter thyroid hormone blood-brain barrier P-glycoprotein copper bis(thiosemicarbazone) CNS drug delivery tight junction proteins adenosine receptor signaling adenosine receptor agonists adenosine receptor antagonist uptake transporters pharmacokinetics glucuronide conjugate metabolite uridine diphosphate-glucuronosyltransferase organic anion-transporting polypeptide BBB penetration Kp,uu,brain prediction MDR1 BCRP ABCB1 knock-out preclinical MDR1 species differences MDR1 inhibitors thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Drug delivery to the brain, restricted by the blood-brain barrier (BBB), remains one of the major obstacles in central nervous system (CNS) drug development. Solute carriers and ATP-binding cassette family (ABC) transporters expressed at the BBB play crucial roles in drug delivery to the brain. Knowledge about brain transporters and the receptors expressed has opened up new opportunities for improving drug delivery to the brain and understanding the pathogenesis of CNS diseases. This Special Issue, entitled the “Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease”, aims to provide information about the latest developments in the field of transporter-mediated drug delivery to the brain, the roles of transporters and receptors in CNS diseases, as well as advances in the methodologies for the evaluation of carrier-mediated drug delivery to the brain. 2025-02-20T13:19:11Z 2025-02-20T13:19:11Z 2024 book ONIX_20250220_9783725825066_306 9783725825066 9783725825059 https://directory.doabooks.org/handle/20.500.12854/152942 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10229 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2505-9 10.3390/books978-3-7258-2505-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725825066 9783725825059 218 Basel open access |
| spellingShingle | amyotrophic lateral sclerosis blood–brain barrier brain microvascular endothelial cells C9orf72 gene proteomics blood brain barrier receptor-mediated transcytosis low-density lipoprotein receptor family low-density lipoprotein receptor-related protein 1 proprotein convertase subtilisin/kexin type 9 central nervous system drug delivery therapeutic blood–brain barrier modification metformin ischemic stroke repurposing transporters in vitro BBB co-culture P-GP Octs permeability ABC transporters brain microvessels peripheral tissues and vessels gene expression patterns RNA-seq WesTM analysis across species choroid plexus epithelial cell lactate monocarboxylate transporter thyroid hormone blood-brain barrier P-glycoprotein copper bis(thiosemicarbazone) CNS drug delivery tight junction proteins adenosine receptor signaling adenosine receptor agonists adenosine receptor antagonist uptake transporters pharmacokinetics glucuronide conjugate metabolite uridine diphosphate-glucuronosyltransferase organic anion-transporting polypeptide BBB penetration Kp,uu,brain prediction MDR1 BCRP ABCB1 knock-out preclinical MDR1 species differences MDR1 inhibitors thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease |
| title | Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease |
| title_full | Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease |
| title_fullStr | Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease |
| title_full_unstemmed | Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease |
| title_short | Roles of Transporters and Receptors in Drug Delivery to the Brain in Health and Disease |
| title_sort | roles of transporters and receptors in drug delivery to the brain in health and disease |
| topic | amyotrophic lateral sclerosis blood–brain barrier brain microvascular endothelial cells C9orf72 gene proteomics blood brain barrier receptor-mediated transcytosis low-density lipoprotein receptor family low-density lipoprotein receptor-related protein 1 proprotein convertase subtilisin/kexin type 9 central nervous system drug delivery therapeutic blood–brain barrier modification metformin ischemic stroke repurposing transporters in vitro BBB co-culture P-GP Octs permeability ABC transporters brain microvessels peripheral tissues and vessels gene expression patterns RNA-seq WesTM analysis across species choroid plexus epithelial cell lactate monocarboxylate transporter thyroid hormone blood-brain barrier P-glycoprotein copper bis(thiosemicarbazone) CNS drug delivery tight junction proteins adenosine receptor signaling adenosine receptor agonists adenosine receptor antagonist uptake transporters pharmacokinetics glucuronide conjugate metabolite uridine diphosphate-glucuronosyltransferase organic anion-transporting polypeptide BBB penetration Kp,uu,brain prediction MDR1 BCRP ABCB1 knock-out preclinical MDR1 species differences MDR1 inhibitors thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | amyotrophic lateral sclerosis blood–brain barrier brain microvascular endothelial cells C9orf72 gene proteomics blood brain barrier receptor-mediated transcytosis low-density lipoprotein receptor family low-density lipoprotein receptor-related protein 1 proprotein convertase subtilisin/kexin type 9 central nervous system drug delivery therapeutic blood–brain barrier modification metformin ischemic stroke repurposing transporters in vitro BBB co-culture P-GP Octs permeability ABC transporters brain microvessels peripheral tissues and vessels gene expression patterns RNA-seq WesTM analysis across species choroid plexus epithelial cell lactate monocarboxylate transporter thyroid hormone blood-brain barrier P-glycoprotein copper bis(thiosemicarbazone) CNS drug delivery tight junction proteins adenosine receptor signaling adenosine receptor agonists adenosine receptor antagonist uptake transporters pharmacokinetics glucuronide conjugate metabolite uridine diphosphate-glucuronosyltransferase organic anion-transporting polypeptide BBB penetration Kp,uu,brain prediction MDR1 BCRP ABCB1 knock-out preclinical MDR1 species differences MDR1 inhibitors thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20250220_9783725825066_306 |