Rotaviruses and Rotavirus Vaccines
Rotaviruses are a major cause of acute gastroenteritis in infants and young children and in the young of various mammalian and avian hosts. Although rotavirus-associated morbidity and mortality have significantly decreased since the introduction of rotavirus vaccines into childhood immunization prog...
Sábháilte in:
| Formáid: | Online |
|---|---|
| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
|
| Ábhair: | |
| Rochtain ar líne: | ONIX_20250220_9783725827893_433 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
|
| _version_ | 1869515506836307968 |
|---|---|
| collection | Directory of Open Access Books |
| description | Rotaviruses are a major cause of acute gastroenteritis in infants and young children and in the young of various mammalian and avian hosts. Although rotavirus-associated morbidity and mortality have significantly decreased since the introduction of rotavirus vaccines into childhood immunization programs, the efficacy of these vaccines is suboptimal in developing countries where they are needed most. Our insight into the molecular epidemiology of rotaviruses has benefited greatly from the application of advanced sequencing and bioinformatic techniques. Combined with the recent development of plasmid-only-based reverse genetics systems, powerful new approaches are now available for the study of all aspects of rotavirus biology, including their replication strategy, the structure and function of their proteins, and their ability to suppress immune responses. Moreover, these technologies provide a possible path for the development of new generations of more effective rotavirus vaccines. This Special Issue of Viruses reviews and explores recent progress made in the analysis of rotavirus replication, viral diversity, genotype–phenotype assignment, correlates of protection, biotechnology, and the development of alternative candidate vaccines. |
| format | Online |
| id | doab-20.500.12854ir-153069 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1530692025-02-20T13:30:44Z Rotaviruses and Rotavirus Vaccines Desselberger, Ulrich Patton, John T. rotavirus high-throughput screening microneutralization assay neutralizing antibody pre-existing immunity porcine rotavirus G5 virus isolation pathogenicity mRNA vaccine structural protein VP7 lipid nanoparticles reverse genetics expression vector rotavirus vaccine recombinant vaccine recombinant antigen structurally modified plant viruses tobacco mosaic virus plant virus adjuvants spherical particles porcine rotavirus A (RVA) serotypes molecular characteristics prevalence cross-species transmission Sub-Saharan Africa reverse genetics system triple-reassortant point mutation next-generation sequencing replication kinetics cell culture ML241 (hydrochloride) MAPK signaling pathway ERK1/2 NF-κB probiotics rotavirus infection histo-blood group antigens glycans diarrhea shedding viroplasm cytoskeleton microtubule actin molecular motors lipid droplets NSP5 NSP2 VP2 VP4 small-animal model nonstructural protein 2 particle assembly genome segment assortment genome packaging replication vaccine T cell regulatory T cell early life layered immunity rotavirus A, B, C P-type reassortment South Africa genotype serial passage culture adaptation gastroenteritis CNS sickness symptoms behavioral responses evolution rotavirus A G9P[4], G9P[6], NSP4 E6 genotype Mozambique antibody human rotavirus live attenuated rotavirus vaccine Rotarix® minigenome RNA-dependent RNA polymerase reporter assay maternal antibodies RV3-BB vaccine n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Rotaviruses are a major cause of acute gastroenteritis in infants and young children and in the young of various mammalian and avian hosts. Although rotavirus-associated morbidity and mortality have significantly decreased since the introduction of rotavirus vaccines into childhood immunization programs, the efficacy of these vaccines is suboptimal in developing countries where they are needed most. Our insight into the molecular epidemiology of rotaviruses has benefited greatly from the application of advanced sequencing and bioinformatic techniques. Combined with the recent development of plasmid-only-based reverse genetics systems, powerful new approaches are now available for the study of all aspects of rotavirus biology, including their replication strategy, the structure and function of their proteins, and their ability to suppress immune responses. Moreover, these technologies provide a possible path for the development of new generations of more effective rotavirus vaccines. This Special Issue of Viruses reviews and explores recent progress made in the analysis of rotavirus replication, viral diversity, genotype–phenotype assignment, correlates of protection, biotechnology, and the development of alternative candidate vaccines. 2025-02-20T13:30:42Z 2025-02-20T13:30:42Z 2024 book ONIX_20250220_9783725827893_433 9783725827893 9783725827909 https://directory.doabooks.org/handle/20.500.12854/153069 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10255 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2790-9 10.3390/books978-3-7258-2790-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725827893 9783725827909 322 Basel open access |
| spellingShingle | rotavirus high-throughput screening microneutralization assay neutralizing antibody pre-existing immunity porcine rotavirus G5 virus isolation pathogenicity mRNA vaccine structural protein VP7 lipid nanoparticles reverse genetics expression vector rotavirus vaccine recombinant vaccine recombinant antigen structurally modified plant viruses tobacco mosaic virus plant virus adjuvants spherical particles porcine rotavirus A (RVA) serotypes molecular characteristics prevalence cross-species transmission Sub-Saharan Africa reverse genetics system triple-reassortant point mutation next-generation sequencing replication kinetics cell culture ML241 (hydrochloride) MAPK signaling pathway ERK1/2 NF-κB probiotics rotavirus infection histo-blood group antigens glycans diarrhea shedding viroplasm cytoskeleton microtubule actin molecular motors lipid droplets NSP5 NSP2 VP2 VP4 small-animal model nonstructural protein 2 particle assembly genome segment assortment genome packaging replication vaccine T cell regulatory T cell early life layered immunity rotavirus A, B, C P-type reassortment South Africa genotype serial passage culture adaptation gastroenteritis CNS sickness symptoms behavioral responses evolution rotavirus A G9P[4], G9P[6], NSP4 E6 genotype Mozambique antibody human rotavirus live attenuated rotavirus vaccine Rotarix® minigenome RNA-dependent RNA polymerase reporter assay maternal antibodies RV3-BB vaccine n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Rotaviruses and Rotavirus Vaccines |
| title | Rotaviruses and Rotavirus Vaccines |
| title_full | Rotaviruses and Rotavirus Vaccines |
| title_fullStr | Rotaviruses and Rotavirus Vaccines |
| title_full_unstemmed | Rotaviruses and Rotavirus Vaccines |
| title_short | Rotaviruses and Rotavirus Vaccines |
| title_sort | rotaviruses and rotavirus vaccines |
| topic | rotavirus high-throughput screening microneutralization assay neutralizing antibody pre-existing immunity porcine rotavirus G5 virus isolation pathogenicity mRNA vaccine structural protein VP7 lipid nanoparticles reverse genetics expression vector rotavirus vaccine recombinant vaccine recombinant antigen structurally modified plant viruses tobacco mosaic virus plant virus adjuvants spherical particles porcine rotavirus A (RVA) serotypes molecular characteristics prevalence cross-species transmission Sub-Saharan Africa reverse genetics system triple-reassortant point mutation next-generation sequencing replication kinetics cell culture ML241 (hydrochloride) MAPK signaling pathway ERK1/2 NF-κB probiotics rotavirus infection histo-blood group antigens glycans diarrhea shedding viroplasm cytoskeleton microtubule actin molecular motors lipid droplets NSP5 NSP2 VP2 VP4 small-animal model nonstructural protein 2 particle assembly genome segment assortment genome packaging replication vaccine T cell regulatory T cell early life layered immunity rotavirus A, B, C P-type reassortment South Africa genotype serial passage culture adaptation gastroenteritis CNS sickness symptoms behavioral responses evolution rotavirus A G9P[4], G9P[6], NSP4 E6 genotype Mozambique antibody human rotavirus live attenuated rotavirus vaccine Rotarix® minigenome RNA-dependent RNA polymerase reporter assay maternal antibodies RV3-BB vaccine n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | rotavirus high-throughput screening microneutralization assay neutralizing antibody pre-existing immunity porcine rotavirus G5 virus isolation pathogenicity mRNA vaccine structural protein VP7 lipid nanoparticles reverse genetics expression vector rotavirus vaccine recombinant vaccine recombinant antigen structurally modified plant viruses tobacco mosaic virus plant virus adjuvants spherical particles porcine rotavirus A (RVA) serotypes molecular characteristics prevalence cross-species transmission Sub-Saharan Africa reverse genetics system triple-reassortant point mutation next-generation sequencing replication kinetics cell culture ML241 (hydrochloride) MAPK signaling pathway ERK1/2 NF-κB probiotics rotavirus infection histo-blood group antigens glycans diarrhea shedding viroplasm cytoskeleton microtubule actin molecular motors lipid droplets NSP5 NSP2 VP2 VP4 small-animal model nonstructural protein 2 particle assembly genome segment assortment genome packaging replication vaccine T cell regulatory T cell early life layered immunity rotavirus A, B, C P-type reassortment South Africa genotype serial passage culture adaptation gastroenteritis CNS sickness symptoms behavioral responses evolution rotavirus A G9P[4], G9P[6], NSP4 E6 genotype Mozambique antibody human rotavirus live attenuated rotavirus vaccine Rotarix® minigenome RNA-dependent RNA polymerase reporter assay maternal antibodies RV3-BB vaccine n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20250220_9783725827893_433 |