Molecular and Cellular Mechanisms of Cancers
This second Special Issue on the Molecular and Cellular Mechanisms of Glioblastoma presents 16 articles on the biology, genetics, and possible treatments against this devastating disease. Pathways to gliomagenesis and new targets were explored, along with epigenetic possibilities like the inhibition...
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| Médium: | Online |
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| Jazyk: | angličtina |
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MDPI - Multidisciplinary Digital Publishing Institute
2025
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| On-line přístup: | ONIX_20250220_9783725829361_497 |
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| _version_ | 1869529112473763840 |
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| collection | Directory of Open Access Books |
| description | This second Special Issue on the Molecular and Cellular Mechanisms of Glioblastoma presents 16 articles on the biology, genetics, and possible treatments against this devastating disease. Pathways to gliomagenesis and new targets were explored, along with epigenetic possibilities like the inhibition of HDAC and the role of miRNA and circular RNA, tumor cell dormancy, cancer stem cells, and other approaches, to try to better understand and possibly combat glioblastoma. |
| format | Online |
| id | doab-20.500.12854ir-153133 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1531332025-02-20T13:36:30Z Molecular and Cellular Mechanisms of Cancers Castresana, Javier S. Meléndez, Bárbara FABP6 invasion angiogenesis glioblastoma corosolic acid glioblastoma cell invasiveness AXL CHIP GAS6 JAK2 THC CBD microglia astrocytes melanoma brain metastasis glioblastoma-derived spheres HDAC inhibitor MEK inhibitor radiation combination therapy single-cell tumor microenvironment copy number aberrations DEPArray DNA damage response treatment resistance temozolomide XRN2 cell motility tumor progression glioblastomas radioresistance cancer stem cells GPM6A PTPRZ1 circular RNA miRNA brain tumor medulloblastoma pituitary adenoma ependymoma signaling pathway diagnosis treatment ribosomal protein reprogramming extra-ribosomal function microenvironment glioma stem cell ribosomal protein S6 ribosome biogenesis transdifferentiation plasticity GBM subtypes SHH signaling Wnt/β-catenin signaling Notch signaling TGFβ signaling BMP signaling Hippo signaling RA signaling Oltipraz apoptosis anticancer therapeutic glioblastoma organoids glioblastoma spheroids cerebral organoids glioblastoma stem cells drug screening glycation glioma methylglyoxal advanced glycation end-products dormancy stemness Chemokine (C-C motif) Receptor-Like (CCRL)1 Schlafen (SLFN)13 Sloan-Kettering Institute (SKI) Cdk5 and Abl Enzyme Substrate (Cables)1 Dachsous Cadherin-Related (DCHS)1 epigenetics DNA methylation n/a reactive oxygen species oxidative stress natural polyphenols fisetin quercetin redox-responsive transcription factors thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics This second Special Issue on the Molecular and Cellular Mechanisms of Glioblastoma presents 16 articles on the biology, genetics, and possible treatments against this devastating disease. Pathways to gliomagenesis and new targets were explored, along with epigenetic possibilities like the inhibition of HDAC and the role of miRNA and circular RNA, tumor cell dormancy, cancer stem cells, and other approaches, to try to better understand and possibly combat glioblastoma. 2025-02-20T13:36:27Z 2025-02-20T13:36:27Z 2024 book ONIX_20250220_9783725829361_497 9783725829361 9783725829354 https://directory.doabooks.org/handle/20.500.12854/153133 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/10386 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-2935-4 10.3390/books978-3-7258-2935-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725829361 9783725829354 370 Basel open access |
| spellingShingle | FABP6 invasion angiogenesis glioblastoma corosolic acid glioblastoma cell invasiveness AXL CHIP GAS6 JAK2 THC CBD microglia astrocytes melanoma brain metastasis glioblastoma-derived spheres HDAC inhibitor MEK inhibitor radiation combination therapy single-cell tumor microenvironment copy number aberrations DEPArray DNA damage response treatment resistance temozolomide XRN2 cell motility tumor progression glioblastomas radioresistance cancer stem cells GPM6A PTPRZ1 circular RNA miRNA brain tumor medulloblastoma pituitary adenoma ependymoma signaling pathway diagnosis treatment ribosomal protein reprogramming extra-ribosomal function microenvironment glioma stem cell ribosomal protein S6 ribosome biogenesis transdifferentiation plasticity GBM subtypes SHH signaling Wnt/β-catenin signaling Notch signaling TGFβ signaling BMP signaling Hippo signaling RA signaling Oltipraz apoptosis anticancer therapeutic glioblastoma organoids glioblastoma spheroids cerebral organoids glioblastoma stem cells drug screening glycation glioma methylglyoxal advanced glycation end-products dormancy stemness Chemokine (C-C motif) Receptor-Like (CCRL)1 Schlafen (SLFN)13 Sloan-Kettering Institute (SKI) Cdk5 and Abl Enzyme Substrate (Cables)1 Dachsous Cadherin-Related (DCHS)1 epigenetics DNA methylation n/a reactive oxygen species oxidative stress natural polyphenols fisetin quercetin redox-responsive transcription factors thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics Molecular and Cellular Mechanisms of Cancers |
| title | Molecular and Cellular Mechanisms of Cancers |
| title_full | Molecular and Cellular Mechanisms of Cancers |
| title_fullStr | Molecular and Cellular Mechanisms of Cancers |
| title_full_unstemmed | Molecular and Cellular Mechanisms of Cancers |
| title_short | Molecular and Cellular Mechanisms of Cancers |
| title_sort | molecular and cellular mechanisms of cancers |
| topic | FABP6 invasion angiogenesis glioblastoma corosolic acid glioblastoma cell invasiveness AXL CHIP GAS6 JAK2 THC CBD microglia astrocytes melanoma brain metastasis glioblastoma-derived spheres HDAC inhibitor MEK inhibitor radiation combination therapy single-cell tumor microenvironment copy number aberrations DEPArray DNA damage response treatment resistance temozolomide XRN2 cell motility tumor progression glioblastomas radioresistance cancer stem cells GPM6A PTPRZ1 circular RNA miRNA brain tumor medulloblastoma pituitary adenoma ependymoma signaling pathway diagnosis treatment ribosomal protein reprogramming extra-ribosomal function microenvironment glioma stem cell ribosomal protein S6 ribosome biogenesis transdifferentiation plasticity GBM subtypes SHH signaling Wnt/β-catenin signaling Notch signaling TGFβ signaling BMP signaling Hippo signaling RA signaling Oltipraz apoptosis anticancer therapeutic glioblastoma organoids glioblastoma spheroids cerebral organoids glioblastoma stem cells drug screening glycation glioma methylglyoxal advanced glycation end-products dormancy stemness Chemokine (C-C motif) Receptor-Like (CCRL)1 Schlafen (SLFN)13 Sloan-Kettering Institute (SKI) Cdk5 and Abl Enzyme Substrate (Cables)1 Dachsous Cadherin-Related (DCHS)1 epigenetics DNA methylation n/a reactive oxygen species oxidative stress natural polyphenols fisetin quercetin redox-responsive transcription factors thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| topic_facet | FABP6 invasion angiogenesis glioblastoma corosolic acid glioblastoma cell invasiveness AXL CHIP GAS6 JAK2 THC CBD microglia astrocytes melanoma brain metastasis glioblastoma-derived spheres HDAC inhibitor MEK inhibitor radiation combination therapy single-cell tumor microenvironment copy number aberrations DEPArray DNA damage response treatment resistance temozolomide XRN2 cell motility tumor progression glioblastomas radioresistance cancer stem cells GPM6A PTPRZ1 circular RNA miRNA brain tumor medulloblastoma pituitary adenoma ependymoma signaling pathway diagnosis treatment ribosomal protein reprogramming extra-ribosomal function microenvironment glioma stem cell ribosomal protein S6 ribosome biogenesis transdifferentiation plasticity GBM subtypes SHH signaling Wnt/β-catenin signaling Notch signaling TGFβ signaling BMP signaling Hippo signaling RA signaling Oltipraz apoptosis anticancer therapeutic glioblastoma organoids glioblastoma spheroids cerebral organoids glioblastoma stem cells drug screening glycation glioma methylglyoxal advanced glycation end-products dormancy stemness Chemokine (C-C motif) Receptor-Like (CCRL)1 Schlafen (SLFN)13 Sloan-Kettering Institute (SKI) Cdk5 and Abl Enzyme Substrate (Cables)1 Dachsous Cadherin-Related (DCHS)1 epigenetics DNA methylation n/a reactive oxygen species oxidative stress natural polyphenols fisetin quercetin redox-responsive transcription factors thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| url | ONIX_20250220_9783725829361_497 |