Neurodegenerative Disease
This Special Issue addresses the problem of treating neurodegenerative diseases from a variety of perspectives, from basic research into the molecular mechanisms responsible for a disease to reviews of the most advanced therapies available. This topic can provide exciting insights into new therapeut...
Uloženo v:
| Médium: | Online |
|---|---|
| Jazyk: | angličtina |
| Vydáno: |
MDPI - Multidisciplinary Digital Publishing Institute
2025
|
| Témata: | |
| On-line přístup: | ONIX_20250812T110751_9783725835089_48 |
| Tagy: |
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| _version_ | 1869518442721181696 |
|---|---|
| collection | Directory of Open Access Books |
| description | This Special Issue addresses the problem of treating neurodegenerative diseases from a variety of perspectives, from basic research into the molecular mechanisms responsible for a disease to reviews of the most advanced therapies available. This topic can provide exciting insights into new therapeutic approaches for various neurodegenerative disorders, expanding our knowledge on the biological basis and clinical research, as well as new challenges and future perspectives in neurodegeneration. |
| format | Online |
| id | doab-20.500.12854ir-165292 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1652922025-08-12T09:18:13Z Neurodegenerative Disease Ricci, Claudia α-synuclein lipids Parkinson’s disease post-translational modification SERCA positive allosteric modulators calcium Alzheimer’s disease beta-amyloid dendritic spines calcium imaging long-term potentiation exosome nasal lavage fluid 5XFAD high-density multielectrode array hippocampal slice neural network Alzheimer’s disease (AD) Aging-Associated Cognitive Decline (AACD) Amyloid Cascade Hypothesis 2.0 (ACH2.0) intraneuronal Aβ (iAβ) Aβ protein precursor (AβPP) AβPP-independent iAβ production pathway ACH2.0-based drugs BACE1/BACE2 activators mRNAs RNA sequencing transcriptome analysis substantia nigra regulatory T cells Amyloid-β status epilepticus claustrum endopiriform nucleus claustroamygdaloid complex neurodegeneration ontogeny polycystic ovary syndrome PCOS amyloid-associated proteins conventional AD unconventional AD amyloid cascade hypothesis (ACH) ACH-based models of AD ACH-based AD drugs ACH2.0 ACH2.0-based models of AD histamine dihydroergotamine Morris water maze novel object recognition terminal nerve olfactory dysfunctions Kallmann syndrome GnRH SARS-CoV-2 lactacystin GRP78 ER stress neuroprotection microglia artemisinins multitargeting neurotherapeutics antisense oligonucleotides (ASOs) motor neuron diseases spinal muscular atrophy amyotrophic lateral sclerosis spinal and bulbar muscular atrophy innovative therapy nusinersen tofersen clinical trials chronic inflammation immune activation neutrophil extracellular traps low-level LPS IP injection peripheral brain flow cytometry microscopy C57BL/6J mice timepoint optimization inflammation matrix metalloproteinase-3 ingenuity pathway analysis gene set enrichment analysis stroke transcriptome n/a thema EDItEUR::M Medicine and Nursing This Special Issue addresses the problem of treating neurodegenerative diseases from a variety of perspectives, from basic research into the molecular mechanisms responsible for a disease to reviews of the most advanced therapies available. This topic can provide exciting insights into new therapeutic approaches for various neurodegenerative disorders, expanding our knowledge on the biological basis and clinical research, as well as new challenges and future perspectives in neurodegeneration. 2025-08-12T09:18:10Z 2025-08-12T09:18:10Z 2025 book ONIX_20250812T110751_9783725835089_48 9783725835089 9783725835072 https://directory.doabooks.org/handle/20.500.12854/165292 eng image/jpeg Attribution 4.0 International https://mdpi.com/books https://mdpi.com/books/pdfview/book/10668 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-3507-2 10.3390/books978-3-7258-3507-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725835089 9783725835072 378 open access |
| spellingShingle | α-synuclein lipids Parkinson’s disease post-translational modification SERCA positive allosteric modulators calcium Alzheimer’s disease beta-amyloid dendritic spines calcium imaging long-term potentiation exosome nasal lavage fluid 5XFAD high-density multielectrode array hippocampal slice neural network Alzheimer’s disease (AD) Aging-Associated Cognitive Decline (AACD) Amyloid Cascade Hypothesis 2.0 (ACH2.0) intraneuronal Aβ (iAβ) Aβ protein precursor (AβPP) AβPP-independent iAβ production pathway ACH2.0-based drugs BACE1/BACE2 activators mRNAs RNA sequencing transcriptome analysis substantia nigra regulatory T cells Amyloid-β status epilepticus claustrum endopiriform nucleus claustroamygdaloid complex neurodegeneration ontogeny polycystic ovary syndrome PCOS amyloid-associated proteins conventional AD unconventional AD amyloid cascade hypothesis (ACH) ACH-based models of AD ACH-based AD drugs ACH2.0 ACH2.0-based models of AD histamine dihydroergotamine Morris water maze novel object recognition terminal nerve olfactory dysfunctions Kallmann syndrome GnRH SARS-CoV-2 lactacystin GRP78 ER stress neuroprotection microglia artemisinins multitargeting neurotherapeutics antisense oligonucleotides (ASOs) motor neuron diseases spinal muscular atrophy amyotrophic lateral sclerosis spinal and bulbar muscular atrophy innovative therapy nusinersen tofersen clinical trials chronic inflammation immune activation neutrophil extracellular traps low-level LPS IP injection peripheral brain flow cytometry microscopy C57BL/6J mice timepoint optimization inflammation matrix metalloproteinase-3 ingenuity pathway analysis gene set enrichment analysis stroke transcriptome n/a thema EDItEUR::M Medicine and Nursing Neurodegenerative Disease |
| title | Neurodegenerative Disease |
| title_full | Neurodegenerative Disease |
| title_fullStr | Neurodegenerative Disease |
| title_full_unstemmed | Neurodegenerative Disease |
| title_short | Neurodegenerative Disease |
| title_sort | neurodegenerative disease |
| topic | α-synuclein lipids Parkinson’s disease post-translational modification SERCA positive allosteric modulators calcium Alzheimer’s disease beta-amyloid dendritic spines calcium imaging long-term potentiation exosome nasal lavage fluid 5XFAD high-density multielectrode array hippocampal slice neural network Alzheimer’s disease (AD) Aging-Associated Cognitive Decline (AACD) Amyloid Cascade Hypothesis 2.0 (ACH2.0) intraneuronal Aβ (iAβ) Aβ protein precursor (AβPP) AβPP-independent iAβ production pathway ACH2.0-based drugs BACE1/BACE2 activators mRNAs RNA sequencing transcriptome analysis substantia nigra regulatory T cells Amyloid-β status epilepticus claustrum endopiriform nucleus claustroamygdaloid complex neurodegeneration ontogeny polycystic ovary syndrome PCOS amyloid-associated proteins conventional AD unconventional AD amyloid cascade hypothesis (ACH) ACH-based models of AD ACH-based AD drugs ACH2.0 ACH2.0-based models of AD histamine dihydroergotamine Morris water maze novel object recognition terminal nerve olfactory dysfunctions Kallmann syndrome GnRH SARS-CoV-2 lactacystin GRP78 ER stress neuroprotection microglia artemisinins multitargeting neurotherapeutics antisense oligonucleotides (ASOs) motor neuron diseases spinal muscular atrophy amyotrophic lateral sclerosis spinal and bulbar muscular atrophy innovative therapy nusinersen tofersen clinical trials chronic inflammation immune activation neutrophil extracellular traps low-level LPS IP injection peripheral brain flow cytometry microscopy C57BL/6J mice timepoint optimization inflammation matrix metalloproteinase-3 ingenuity pathway analysis gene set enrichment analysis stroke transcriptome n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | α-synuclein lipids Parkinson’s disease post-translational modification SERCA positive allosteric modulators calcium Alzheimer’s disease beta-amyloid dendritic spines calcium imaging long-term potentiation exosome nasal lavage fluid 5XFAD high-density multielectrode array hippocampal slice neural network Alzheimer’s disease (AD) Aging-Associated Cognitive Decline (AACD) Amyloid Cascade Hypothesis 2.0 (ACH2.0) intraneuronal Aβ (iAβ) Aβ protein precursor (AβPP) AβPP-independent iAβ production pathway ACH2.0-based drugs BACE1/BACE2 activators mRNAs RNA sequencing transcriptome analysis substantia nigra regulatory T cells Amyloid-β status epilepticus claustrum endopiriform nucleus claustroamygdaloid complex neurodegeneration ontogeny polycystic ovary syndrome PCOS amyloid-associated proteins conventional AD unconventional AD amyloid cascade hypothesis (ACH) ACH-based models of AD ACH-based AD drugs ACH2.0 ACH2.0-based models of AD histamine dihydroergotamine Morris water maze novel object recognition terminal nerve olfactory dysfunctions Kallmann syndrome GnRH SARS-CoV-2 lactacystin GRP78 ER stress neuroprotection microglia artemisinins multitargeting neurotherapeutics antisense oligonucleotides (ASOs) motor neuron diseases spinal muscular atrophy amyotrophic lateral sclerosis spinal and bulbar muscular atrophy innovative therapy nusinersen tofersen clinical trials chronic inflammation immune activation neutrophil extracellular traps low-level LPS IP injection peripheral brain flow cytometry microscopy C57BL/6J mice timepoint optimization inflammation matrix metalloproteinase-3 ingenuity pathway analysis gene set enrichment analysis stroke transcriptome n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20250812T110751_9783725835089_48 |