Topoisomerases as Targets for Novel Drug Discovery
Topoisomerases play a crucial role in controlling DNA topology and have long been established as the therapeutic targets of several clinically successful antibacterial and anticancer drugs. Despite decades of clinical use, topoisomerase-targeting agents still face several limitations, including anti...
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| 格式: | Online |
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| 語言: | 英语 |
| 出版: |
MDPI - Multidisciplinary Digital Publishing Institute
2026
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| 主題: | |
| 在線閱讀: | ONIX_20260416T142754_9783725860814_21 |
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沒有標簽, 成為第一個標記此記錄!
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| _version_ | 1869530824422981632 |
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| collection | Directory of Open Access Books |
| description | Topoisomerases play a crucial role in controlling DNA topology and have long been established as the therapeutic targets of several clinically successful antibacterial and anticancer drugs. Despite decades of clinical use, topoisomerase-targeting agents still face several limitations, including antibiotic resistance, off-target toxicity, the induction of secondary malignancies, cardiotoxicity, and limited tumor selectivity. These challenges have driven extensive research toward elucidating novel inhibitory mechanisms, designing more selective or multitarget topoisomerase inhibitors, and developing combination strategies that enhance therapeutic efficacy and reduce toxicity. Topoisomerases as Targets for Novel Drug Discovery is a Reprint of the Special Issue in Pharmaceuticals and contains a collection of review and research articles highlighting recent progress made in overcoming these challenges. The contributions explore the discovery and development of new topoisomerase inhibitors, innovative strategies to improve therapeutic selectivity and safety, and novel insights into the management of chemotherapy-induced toxicities. Overall, these articles highlight emerging trends in topoisomerase research and emphasize the importance of interdisciplinary approaches that connect structural biology, chemistry, and pharmacology to advance the next generation of topoisomerase-targeting therapies. |
| format | Online |
| id | doab-20.500.12854ir-175066 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1750662026-04-16T18:45:33Z Topoisomerases as Targets for Novel Drug Discovery Perdih, Andrej Topoisomerase Type I topoisomerase Type II topoisomerase DNA Gyrase DNA topology Catalytic inhibitors Topo II poisons DNA gyrase inhibitors Anticancer agents Antibacterial agents thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Topoisomerases play a crucial role in controlling DNA topology and have long been established as the therapeutic targets of several clinically successful antibacterial and anticancer drugs. Despite decades of clinical use, topoisomerase-targeting agents still face several limitations, including antibiotic resistance, off-target toxicity, the induction of secondary malignancies, cardiotoxicity, and limited tumor selectivity. These challenges have driven extensive research toward elucidating novel inhibitory mechanisms, designing more selective or multitarget topoisomerase inhibitors, and developing combination strategies that enhance therapeutic efficacy and reduce toxicity. Topoisomerases as Targets for Novel Drug Discovery is a Reprint of the Special Issue in Pharmaceuticals and contains a collection of review and research articles highlighting recent progress made in overcoming these challenges. The contributions explore the discovery and development of new topoisomerase inhibitors, innovative strategies to improve therapeutic selectivity and safety, and novel insights into the management of chemotherapy-induced toxicities. Overall, these articles highlight emerging trends in topoisomerase research and emphasize the importance of interdisciplinary approaches that connect structural biology, chemistry, and pharmacology to advance the next generation of topoisomerase-targeting therapies. 2026-04-16T18:45:26Z 2026-04-16T18:45:26Z 2025 book ONIX_20260416T142754_9783725860814_21 9783725860814 9783725860821 https://directory.doabooks.org/handle/20.500.12854/175066 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/ https://mdpi.com/books/pdfview/book/11969 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-7258-6082-1 10.3390/books978-3-7258-6082-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783725860814 9783725860821 198 CH open access |
| spellingShingle | Topoisomerase Type I topoisomerase Type II topoisomerase DNA Gyrase DNA topology Catalytic inhibitors Topo II poisons DNA gyrase inhibitors Anticancer agents Antibacterial agents thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Topoisomerases as Targets for Novel Drug Discovery |
| title | Topoisomerases as Targets for Novel Drug Discovery |
| title_full | Topoisomerases as Targets for Novel Drug Discovery |
| title_fullStr | Topoisomerases as Targets for Novel Drug Discovery |
| title_full_unstemmed | Topoisomerases as Targets for Novel Drug Discovery |
| title_short | Topoisomerases as Targets for Novel Drug Discovery |
| title_sort | topoisomerases as targets for novel drug discovery |
| topic | Topoisomerase Type I topoisomerase Type II topoisomerase DNA Gyrase DNA topology Catalytic inhibitors Topo II poisons DNA gyrase inhibitors Anticancer agents Antibacterial agents thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Topoisomerase Type I topoisomerase Type II topoisomerase DNA Gyrase DNA topology Catalytic inhibitors Topo II poisons DNA gyrase inhibitors Anticancer agents Antibacterial agents thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20260416T142754_9783725860814_21 |