Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies
Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. Whil...
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| Liŋkkat: | 612595 |
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| author | Jordan, Bénédicte F. Sonveaux, Pierre |
| author_browse | Jordan, Bénédicte F. Sonveaux, Pierre |
| author_facet | Jordan, Bénédicte F. Sonveaux, Pierre |
| author_sort | Jordan, Bénédicte F. |
| collection | Directory of Open Access Books |
| description | Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species
(ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes
the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and
human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells
become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953).
Because of this so-called “oxygen enhancement effect”, the radiation dose required to
achieve the same biologic effect is about three times higher in the absence of oxygen than in
the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009).
Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well
oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of
fractionated radiotherapy (Rojas et al., 1992). |
| format | Online |
| id | doab-20.500.12854ir-32675 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-326752025-05-08T10:25:43Z Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies Jordan, Bénédicte F. Sonveaux, Pierre tumor systematic therapies hypoxia radiotherapy cancer sensitivity tumor systematic therapies hypoxia radiotherapy cancer sensitivity Blood Hemodynamics Magnetic resonance imaging Neoplasm Oxygen Perfusion Radiation therapy Vasodilation Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953). Because of this so-called “oxygen enhancement effect”, the radiation dose required to achieve the same biologic effect is about three times higher in the absence of oxygen than in the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009). Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of fractionated radiotherapy (Rojas et al., 1992). 2021-02-10T12:58:18Z 2019-10-04 14:29:40 2020-04-01T14:06:57Z 2016-08-01 23:55 2019-10-04 14:29:40 2020-04-01T14:06:57Z 2016-12-31 23:55:55 2019-10-04 14:29:40 2020-04-01T14:06:57Z 2011 chapter 612595 OCN: 1030814339 http://library.oapen.org/handle/20.500.12657/32342 https://directory.doabooks.org/handle/20.500.12854/32675 eng open access image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/32342/1/612595.pdf https://library.oapen.org/bitstream/20.500.12657/32342/1/612595.pdf https://library.oapen.org/bitstream/20.500.12657/32342/1/612595.pdf https://library.oapen.org/bitstream/20.500.12657/32342/1/612595.pdf https://library.oapen.org/bitstream/20.500.12657/32342/1/612595.pdf InTechOpen 10.5772/23332 10.5772/23332 035ecc65-6737-43cf-a13a-6bdf67ce01f4 Advances in Cancer Therapy FP7 Ideas: European Research Council 7292b17b-f01a-4016-94d3-d7fb5ef9fb79 European Research Council (ERC) EU collection 243188 FP7 open access |
| spellingShingle | tumor systematic therapies hypoxia radiotherapy cancer sensitivity tumor systematic therapies hypoxia radiotherapy cancer sensitivity Blood Hemodynamics Magnetic resonance imaging Neoplasm Oxygen Perfusion Radiation therapy Vasodilation Jordan, Bénédicte F. Sonveaux, Pierre Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies |
| title | Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies |
| title_full | Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies |
| title_fullStr | Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies |
| title_full_unstemmed | Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies |
| title_short | Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies |
| title_sort | chapter 13 targeting tumor perfusion and oxygenation modulates hypoxia and cancer sensitivity to radiotherapy and systemic therapies |
| topic | tumor systematic therapies hypoxia radiotherapy cancer sensitivity tumor systematic therapies hypoxia radiotherapy cancer sensitivity Blood Hemodynamics Magnetic resonance imaging Neoplasm Oxygen Perfusion Radiation therapy Vasodilation |
| topic_facet | tumor systematic therapies hypoxia radiotherapy cancer sensitivity tumor systematic therapies hypoxia radiotherapy cancer sensitivity Blood Hemodynamics Magnetic resonance imaging Neoplasm Oxygen Perfusion Radiation therapy Vasodilation |
| url | 612595 |
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