Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies

Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. Whil...

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Bibliographic Details

Main Authors:	Jordan, Bénédicte F., Sonveaux, Pierre
Format:	Online
Language:	English
Published:	InTechOpen 2021
Subjects:	tumor systematic therapies hypoxia radiotherapy cancer sensitivity Blood Hemodynamics Magnetic resonance imaging Neoplasm Oxygen Perfusion Radiation therapy Vasodilation
Online Access:	612595
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