Apoptotic Cell Clearance in Health and Disease
Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated t...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Online |
| Sprache: | Englisch |
| Veröffentlicht: |
Frontiers Media SA
2021
|
| Schlagworte: | |
| Online-Zugang: | 32070 |
| Tags: |
Keine Tags, Fügen Sie das erste Tag hinzu!
|
| _version_ | 1869521638003834880 |
|---|---|
| author | Amiram Ariel Kirsten Lauber Estee Kurant |
| author_browse | Amiram Ariel Estee Kurant Kirsten Lauber |
| author_facet | Amiram Ariel Kirsten Lauber Estee Kurant |
| author_sort | Amiram Ariel |
| collection | Directory of Open Access Books |
| description | Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury. |
| format | Online |
| id | doab-20.500.12854ir-41029 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-410292024-03-30T23:22:52Z Apoptotic Cell Clearance in Health and Disease Amiram Ariel Kirsten Lauber Estee Kurant R5-920 RC581-607 Phagocytes immune-regulation development Efferocytosis Homeostasis neurodegeneration tumorigenesis Apoptosis receptor-ligand interactions thema EDItEUR::M Medicine and Nursing Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury. 2021-02-11T08:18:11Z 2021-02-11T08:18:11Z 2019-01-23 14:53:43 2018 book 32070 16648714 9782889456888 https://directory.doabooks.org/handle/20.500.12854/41029 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5442/apoptotic-cell-clearance-in-health-and-disease?utm_source=G-BLO&utm_medium=WEXT&utm_campaign=ECO_FRTOP_20181000_eBook Frontiers Media SA 10.3389/978-2-88945-688-8 10.3389/978-2-88945-688-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456888 294 open access |
| spellingShingle | R5-920 RC581-607 Phagocytes immune-regulation development Efferocytosis Homeostasis neurodegeneration tumorigenesis Apoptosis receptor-ligand interactions thema EDItEUR::M Medicine and Nursing Amiram Ariel Kirsten Lauber Estee Kurant Apoptotic Cell Clearance in Health and Disease |
| title | Apoptotic Cell Clearance in Health and Disease |
| title_full | Apoptotic Cell Clearance in Health and Disease |
| title_fullStr | Apoptotic Cell Clearance in Health and Disease |
| title_full_unstemmed | Apoptotic Cell Clearance in Health and Disease |
| title_short | Apoptotic Cell Clearance in Health and Disease |
| title_sort | apoptotic cell clearance in health and disease |
| topic | R5-920 RC581-607 Phagocytes immune-regulation development Efferocytosis Homeostasis neurodegeneration tumorigenesis Apoptosis receptor-ligand interactions thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Phagocytes immune-regulation development Efferocytosis Homeostasis neurodegeneration tumorigenesis Apoptosis receptor-ligand interactions thema EDItEUR::M Medicine and Nursing |
| url | 32070 |
| work_keys_str_mv | AT amiramariel apoptoticcellclearanceinhealthanddisease AT kirstenlauber apoptoticcellclearanceinhealthanddisease AT esteekurant apoptoticcellclearanceinhealthanddisease |