Biomimetic Radical Chemistry and Applications
The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an i...
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| প্রধান লেখক: | |
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 44857 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
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| _version_ | 1869514800872030208 |
|---|---|
| author | Chatgilialoglu, Chryssostomos |
| author_browse | Chatgilialoglu, Chryssostomos |
| author_facet | Chatgilialoglu, Chryssostomos |
| author_sort | Chatgilialoglu, Chryssostomos |
| collection | Directory of Open Access Books |
| description | The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator. |
| format | Online |
| id | doab-20.500.12854ir-42284 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-422842024-04-05T12:31:47Z Biomimetic Radical Chemistry and Applications Chatgilialoglu, Chryssostomos QH301-705.5 Q1-390 gold nanoparticles inhomogeneous reactions chemical nuclease liposomal somatostatin replication fork stalling lipid bilayer membranes 2c-3e S?S-bonded intermediates cell micropolarity maps protein labeling time-resolved spectroscopy 1 pulse radiolysis nucleosides 2-thiouracil [1 lipidomics radicals reactive aldehydes iron porphyrin photolysis oxidative damage free fatty acids charge transfer fragmentation biomimetic radical reaction sulfones bioinspired chemical catalysis genomic and epigenomic instability ATRPase DNA methylation oxononenal trans lipid copper membrane fluidity maps mitochondrial uncoupling protein heme thiyl radicals oxidation anomeric spironucleosides protein stability laser flash photolysis type 2 diabetes stationary radiolysis confocal microscopy iron(IV)-oxo 5]-radical translocation diabetes DNA hole transfer free radical oxidation radical reaction kinetic studies circular dichroism catalase activity thiobases intercalation electron transfer iron-mediated ATRP Fenton reaction EPR spectroscopy glycogen phosphorylase azidoalkylation free radicals gamma radiolysis quantum dynamics hydrogen peroxide carboazidation ?OH and ?N3 radicals 5? oligonucleotides Raman spectroscopy azides peroxidation photo-ionization guanine quadruplexes 8-cyclopurines beta cells cross-link miRNAs oxidative DNA damage DNA damage modified nucleosides Julia–Kocienski olefination DNA oxidation therapeutic proteins DNA replication stress electron holes singlet oxygen radiosensitizers cellular response hydroxynonenal isomerization ?-radiolysis histone modifications 8-oxo-dG 6-dioxa-4-azaspiro[4.5]decane retarded delivery reaction mechanism DNA albumin TD-DFT methods nucleobase derivatives bio-mimicking catalyst thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator. 2021-02-11T09:11:55Z 2021-02-11T09:11:55Z 2020-04-07 23:07:09 2020 book 44857 9783039283934 9783039283927 https://directory.doabooks.org/handle/20.500.12854/42284 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2134 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-393-4 10.3390/books978-3-03928-393-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039283934 9783039283927 300 open access |
| spellingShingle | QH301-705.5 Q1-390 gold nanoparticles inhomogeneous reactions chemical nuclease liposomal somatostatin replication fork stalling lipid bilayer membranes 2c-3e S?S-bonded intermediates cell micropolarity maps protein labeling time-resolved spectroscopy 1 pulse radiolysis nucleosides 2-thiouracil [1 lipidomics radicals reactive aldehydes iron porphyrin photolysis oxidative damage free fatty acids charge transfer fragmentation biomimetic radical reaction sulfones bioinspired chemical catalysis genomic and epigenomic instability ATRPase DNA methylation oxononenal trans lipid copper membrane fluidity maps mitochondrial uncoupling protein heme thiyl radicals oxidation anomeric spironucleosides protein stability laser flash photolysis type 2 diabetes stationary radiolysis confocal microscopy iron(IV)-oxo 5]-radical translocation diabetes DNA hole transfer free radical oxidation radical reaction kinetic studies circular dichroism catalase activity thiobases intercalation electron transfer iron-mediated ATRP Fenton reaction EPR spectroscopy glycogen phosphorylase azidoalkylation free radicals gamma radiolysis quantum dynamics hydrogen peroxide carboazidation ?OH and ?N3 radicals 5? oligonucleotides Raman spectroscopy azides peroxidation photo-ionization guanine quadruplexes 8-cyclopurines beta cells cross-link miRNAs oxidative DNA damage DNA damage modified nucleosides Julia–Kocienski olefination DNA oxidation therapeutic proteins DNA replication stress electron holes singlet oxygen radiosensitizers cellular response hydroxynonenal isomerization ?-radiolysis histone modifications 8-oxo-dG 6-dioxa-4-azaspiro[4.5]decane retarded delivery reaction mechanism DNA albumin TD-DFT methods nucleobase derivatives bio-mimicking catalyst thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Chatgilialoglu, Chryssostomos Biomimetic Radical Chemistry and Applications |
| title | Biomimetic Radical Chemistry and Applications |
| title_full | Biomimetic Radical Chemistry and Applications |
| title_fullStr | Biomimetic Radical Chemistry and Applications |
| title_full_unstemmed | Biomimetic Radical Chemistry and Applications |
| title_short | Biomimetic Radical Chemistry and Applications |
| title_sort | biomimetic radical chemistry and applications |
| topic | QH301-705.5 Q1-390 gold nanoparticles inhomogeneous reactions chemical nuclease liposomal somatostatin replication fork stalling lipid bilayer membranes 2c-3e S?S-bonded intermediates cell micropolarity maps protein labeling time-resolved spectroscopy 1 pulse radiolysis nucleosides 2-thiouracil [1 lipidomics radicals reactive aldehydes iron porphyrin photolysis oxidative damage free fatty acids charge transfer fragmentation biomimetic radical reaction sulfones bioinspired chemical catalysis genomic and epigenomic instability ATRPase DNA methylation oxononenal trans lipid copper membrane fluidity maps mitochondrial uncoupling protein heme thiyl radicals oxidation anomeric spironucleosides protein stability laser flash photolysis type 2 diabetes stationary radiolysis confocal microscopy iron(IV)-oxo 5]-radical translocation diabetes DNA hole transfer free radical oxidation radical reaction kinetic studies circular dichroism catalase activity thiobases intercalation electron transfer iron-mediated ATRP Fenton reaction EPR spectroscopy glycogen phosphorylase azidoalkylation free radicals gamma radiolysis quantum dynamics hydrogen peroxide carboazidation ?OH and ?N3 radicals 5? oligonucleotides Raman spectroscopy azides peroxidation photo-ionization guanine quadruplexes 8-cyclopurines beta cells cross-link miRNAs oxidative DNA damage DNA damage modified nucleosides Julia–Kocienski olefination DNA oxidation therapeutic proteins DNA replication stress electron holes singlet oxygen radiosensitizers cellular response hydroxynonenal isomerization ?-radiolysis histone modifications 8-oxo-dG 6-dioxa-4-azaspiro[4.5]decane retarded delivery reaction mechanism DNA albumin TD-DFT methods nucleobase derivatives bio-mimicking catalyst thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Q1-390 gold nanoparticles inhomogeneous reactions chemical nuclease liposomal somatostatin replication fork stalling lipid bilayer membranes 2c-3e S?S-bonded intermediates cell micropolarity maps protein labeling time-resolved spectroscopy 1 pulse radiolysis nucleosides 2-thiouracil [1 lipidomics radicals reactive aldehydes iron porphyrin photolysis oxidative damage free fatty acids charge transfer fragmentation biomimetic radical reaction sulfones bioinspired chemical catalysis genomic and epigenomic instability ATRPase DNA methylation oxononenal trans lipid copper membrane fluidity maps mitochondrial uncoupling protein heme thiyl radicals oxidation anomeric spironucleosides protein stability laser flash photolysis type 2 diabetes stationary radiolysis confocal microscopy iron(IV)-oxo 5]-radical translocation diabetes DNA hole transfer free radical oxidation radical reaction kinetic studies circular dichroism catalase activity thiobases intercalation electron transfer iron-mediated ATRP Fenton reaction EPR spectroscopy glycogen phosphorylase azidoalkylation free radicals gamma radiolysis quantum dynamics hydrogen peroxide carboazidation ?OH and ?N3 radicals 5? oligonucleotides Raman spectroscopy azides peroxidation photo-ionization guanine quadruplexes 8-cyclopurines beta cells cross-link miRNAs oxidative DNA damage DNA damage modified nucleosides Julia–Kocienski olefination DNA oxidation therapeutic proteins DNA replication stress electron holes singlet oxygen radiosensitizers cellular response hydroxynonenal isomerization ?-radiolysis histone modifications 8-oxo-dG 6-dioxa-4-azaspiro[4.5]decane retarded delivery reaction mechanism DNA albumin TD-DFT methods nucleobase derivatives bio-mimicking catalyst thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 44857 |
| work_keys_str_mv | AT chatgilialogluchryssostomos biomimeticradicalchemistryandapplications |