Carbohydrates 2018
This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable a...
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| Glavni autori: | , |
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| Format: | Online |
| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Teme: | |
| Online pristup: | 44858 |
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Bez oznaka, Budi prvi tko označuje ovaj zapis!
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| _version_ | 1869521053470949376 |
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| author | Rauter, Amélia Pilar Xavier, Nuno Manuel |
| author_browse | Rauter, Amélia Pilar Xavier, Nuno Manuel |
| author_facet | Rauter, Amélia Pilar Xavier, Nuno Manuel |
| author_sort | Rauter, Amélia Pilar |
| collection | Directory of Open Access Books |
| description | This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research. |
| format | Online |
| id | doab-20.500.12854ir-42687 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-426872024-04-05T12:39:14Z Carbohydrates 2018 Rauter, Amélia Pilar Xavier, Nuno Manuel QD1-999 Q1-390 chitosan cancer treatment n/a theobromine multivalent carbohydrate glycomimetic capsular polysaccharide isonucleosides carbohydrate-based antitumor vaccines carbohydrate antigen sugars Alzheimer’s disease conjugate vaccines drug development microparticles cancer diagnosis polyhydroxypiperidines Streptococcus pneumoniae iminosugar oral films Group B Streptococcus C-glucosyl flavonoids glycosidase inhibition polyhydroxyazepanes carbohydrate antigens binding affinity A?1-42 glucosidase inhibition lectin Mitsunobu reaction Microwave reactions chromen-4-ones iminosugars flavones cholinesterase inhibitors chemoselective glycoclusters lead optimization PAMPA oxime bioactive peptides molecular modeling buccal delivery warburg effect aminooxy miglustat miglitol thema EDItEUR::P Mathematics and Science::PN Chemistry This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research. 2021-02-11T09:30:41Z 2021-02-11T09:30:41Z 2020-04-07 23:07:09 2020 book 44858 9783039283170 9783039283163 https://directory.doabooks.org/handle/20.500.12854/42687 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2135 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-317-0 10.3390/books978-3-03928-317-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039283170 9783039283163 172 open access |
| spellingShingle | QD1-999 Q1-390 chitosan cancer treatment n/a theobromine multivalent carbohydrate glycomimetic capsular polysaccharide isonucleosides carbohydrate-based antitumor vaccines carbohydrate antigen sugars Alzheimer’s disease conjugate vaccines drug development microparticles cancer diagnosis polyhydroxypiperidines Streptococcus pneumoniae iminosugar oral films Group B Streptococcus C-glucosyl flavonoids glycosidase inhibition polyhydroxyazepanes carbohydrate antigens binding affinity A?1-42 glucosidase inhibition lectin Mitsunobu reaction Microwave reactions chromen-4-ones iminosugars flavones cholinesterase inhibitors chemoselective glycoclusters lead optimization PAMPA oxime bioactive peptides molecular modeling buccal delivery warburg effect aminooxy miglustat miglitol thema EDItEUR::P Mathematics and Science::PN Chemistry Rauter, Amélia Pilar Xavier, Nuno Manuel Carbohydrates 2018 |
| title | Carbohydrates 2018 |
| title_full | Carbohydrates 2018 |
| title_fullStr | Carbohydrates 2018 |
| title_full_unstemmed | Carbohydrates 2018 |
| title_short | Carbohydrates 2018 |
| title_sort | carbohydrates 2018 |
| topic | QD1-999 Q1-390 chitosan cancer treatment n/a theobromine multivalent carbohydrate glycomimetic capsular polysaccharide isonucleosides carbohydrate-based antitumor vaccines carbohydrate antigen sugars Alzheimer’s disease conjugate vaccines drug development microparticles cancer diagnosis polyhydroxypiperidines Streptococcus pneumoniae iminosugar oral films Group B Streptococcus C-glucosyl flavonoids glycosidase inhibition polyhydroxyazepanes carbohydrate antigens binding affinity A?1-42 glucosidase inhibition lectin Mitsunobu reaction Microwave reactions chromen-4-ones iminosugars flavones cholinesterase inhibitors chemoselective glycoclusters lead optimization PAMPA oxime bioactive peptides molecular modeling buccal delivery warburg effect aminooxy miglustat miglitol thema EDItEUR::P Mathematics and Science::PN Chemistry |
| topic_facet | QD1-999 Q1-390 chitosan cancer treatment n/a theobromine multivalent carbohydrate glycomimetic capsular polysaccharide isonucleosides carbohydrate-based antitumor vaccines carbohydrate antigen sugars Alzheimer’s disease conjugate vaccines drug development microparticles cancer diagnosis polyhydroxypiperidines Streptococcus pneumoniae iminosugar oral films Group B Streptococcus C-glucosyl flavonoids glycosidase inhibition polyhydroxyazepanes carbohydrate antigens binding affinity A?1-42 glucosidase inhibition lectin Mitsunobu reaction Microwave reactions chromen-4-ones iminosugars flavones cholinesterase inhibitors chemoselective glycoclusters lead optimization PAMPA oxime bioactive peptides molecular modeling buccal delivery warburg effect aminooxy miglustat miglitol thema EDItEUR::P Mathematics and Science::PN Chemistry |
| url | 44858 |
| work_keys_str_mv | AT rauterameliapilar carbohydrates2018 AT xaviernunomanuel carbohydrates2018 |