Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug tran...
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| Materialtyp: | Online |
| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| _version_ | 1869519733970173952 |
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| author | Lee, Hye Suk Liu, Kwang-Hyeon |
| author_browse | Lee, Hye Suk Liu, Kwang-Hyeon |
| author_facet | Lee, Hye Suk Liu, Kwang-Hyeon |
| author_sort | Lee, Hye Suk |
| collection | Directory of Open Access Books |
| description | Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis. |
| format | Online |
| id | doab-20.500.12854ir-45509 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-455092024-03-30T23:22:33Z Drug Metabolism, Pharmacokinetics and Bioanalysis Lee, Hye Suk Liu, Kwang-Hyeon R5-920 RM1-950 human liver microsomes alcohol addiction UGT ultra-high-pressure liquid chromatography adalimumab procainamide LC-MS/MS DA-9805 paeonol LC-QTOF-MS/MS YRA-1909 chlorogenic acid immunoprecipitation Eurycoma longifolia CYP caffeic acid rat pharmaceutical excipient Korean red ginseng extract Stauntonia hexaphylla leaf extract bioanalysis HPLC-MS/MS B6 eurycomanone bioavailability drying technology GB3 diclofenac 129-Glatm1Kul/J aglycone caffeic acid O-glucuronides organic anion transporting polypeptide protein precipitation metabolic stability Fabry disease biopharmaceuticals imperatorin neochlorogenic acid gastric ulcer saikosaponin a hair anthraquinone acetyl tributyl citrate pharmacokinetics brain distribution mematine ethyl glucuronide pharmacokinetic loxoprofen liquid chromatography-quadrupole TOF MS glucuronidation esomeprazole metformin cytochrome P450 glycoside AUDIT score protein stability efficacy LC-HR/MS cryptochlorogenic acid aceclofenac drug interaction liquid chromatography-tandem mass spectrometry Osthenol plasma N-acetylprocainamide diabetes thema EDItEUR::M Medicine and Nursing Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis. 2021-02-11T11:49:09Z 2021-02-11T11:49:09Z 2019-06-26 08:44:06 2019 book 33676 9783038979166 9783038979173 https://directory.doabooks.org/handle/20.500.12854/45509 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1337 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-917-3 10.3390/books978-3-03897-917-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038979166 9783038979173 230 open access |
| spellingShingle | R5-920 RM1-950 human liver microsomes alcohol addiction UGT ultra-high-pressure liquid chromatography adalimumab procainamide LC-MS/MS DA-9805 paeonol LC-QTOF-MS/MS YRA-1909 chlorogenic acid immunoprecipitation Eurycoma longifolia CYP caffeic acid rat pharmaceutical excipient Korean red ginseng extract Stauntonia hexaphylla leaf extract bioanalysis HPLC-MS/MS B6 eurycomanone bioavailability drying technology GB3 diclofenac 129-Glatm1Kul/J aglycone caffeic acid O-glucuronides organic anion transporting polypeptide protein precipitation metabolic stability Fabry disease biopharmaceuticals imperatorin neochlorogenic acid gastric ulcer saikosaponin a hair anthraquinone acetyl tributyl citrate pharmacokinetics brain distribution mematine ethyl glucuronide pharmacokinetic loxoprofen liquid chromatography-quadrupole TOF MS glucuronidation esomeprazole metformin cytochrome P450 glycoside AUDIT score protein stability efficacy LC-HR/MS cryptochlorogenic acid aceclofenac drug interaction liquid chromatography-tandem mass spectrometry Osthenol plasma N-acetylprocainamide diabetes thema EDItEUR::M Medicine and Nursing Lee, Hye Suk Liu, Kwang-Hyeon Drug Metabolism, Pharmacokinetics and Bioanalysis |
| title | Drug Metabolism, Pharmacokinetics and Bioanalysis |
| title_full | Drug Metabolism, Pharmacokinetics and Bioanalysis |
| title_fullStr | Drug Metabolism, Pharmacokinetics and Bioanalysis |
| title_full_unstemmed | Drug Metabolism, Pharmacokinetics and Bioanalysis |
| title_short | Drug Metabolism, Pharmacokinetics and Bioanalysis |
| title_sort | drug metabolism pharmacokinetics and bioanalysis |
| topic | R5-920 RM1-950 human liver microsomes alcohol addiction UGT ultra-high-pressure liquid chromatography adalimumab procainamide LC-MS/MS DA-9805 paeonol LC-QTOF-MS/MS YRA-1909 chlorogenic acid immunoprecipitation Eurycoma longifolia CYP caffeic acid rat pharmaceutical excipient Korean red ginseng extract Stauntonia hexaphylla leaf extract bioanalysis HPLC-MS/MS B6 eurycomanone bioavailability drying technology GB3 diclofenac 129-Glatm1Kul/J aglycone caffeic acid O-glucuronides organic anion transporting polypeptide protein precipitation metabolic stability Fabry disease biopharmaceuticals imperatorin neochlorogenic acid gastric ulcer saikosaponin a hair anthraquinone acetyl tributyl citrate pharmacokinetics brain distribution mematine ethyl glucuronide pharmacokinetic loxoprofen liquid chromatography-quadrupole TOF MS glucuronidation esomeprazole metformin cytochrome P450 glycoside AUDIT score protein stability efficacy LC-HR/MS cryptochlorogenic acid aceclofenac drug interaction liquid chromatography-tandem mass spectrometry Osthenol plasma N-acetylprocainamide diabetes thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RM1-950 human liver microsomes alcohol addiction UGT ultra-high-pressure liquid chromatography adalimumab procainamide LC-MS/MS DA-9805 paeonol LC-QTOF-MS/MS YRA-1909 chlorogenic acid immunoprecipitation Eurycoma longifolia CYP caffeic acid rat pharmaceutical excipient Korean red ginseng extract Stauntonia hexaphylla leaf extract bioanalysis HPLC-MS/MS B6 eurycomanone bioavailability drying technology GB3 diclofenac 129-Glatm1Kul/J aglycone caffeic acid O-glucuronides organic anion transporting polypeptide protein precipitation metabolic stability Fabry disease biopharmaceuticals imperatorin neochlorogenic acid gastric ulcer saikosaponin a hair anthraquinone acetyl tributyl citrate pharmacokinetics brain distribution mematine ethyl glucuronide pharmacokinetic loxoprofen liquid chromatography-quadrupole TOF MS glucuronidation esomeprazole metformin cytochrome P450 glycoside AUDIT score protein stability efficacy LC-HR/MS cryptochlorogenic acid aceclofenac drug interaction liquid chromatography-tandem mass spectrometry Osthenol plasma N-acetylprocainamide diabetes thema EDItEUR::M Medicine and Nursing |
| url | 33676 |
| work_keys_str_mv | AT leehyesuk drugmetabolismpharmacokineticsandbioanalysis AT liukwanghyeon drugmetabolismpharmacokineticsandbioanalysis |