Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches

This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The app...

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Bibliografski detalji
Glavni autor:	Bermejo, Marival
Format:	Online
Jezik:	engleski
Izdano:	MDPI - Multidisciplinary Digital Publishing Institute 2021
Teme:	R5-920 RM1-950 in vitro dissolution microscopy imaging modulation ionotropic gelation laponite biowaiver beads model polymer/clay composite flow bioequivalence oral absorption curcumin P-gp liquid–liquid phase separation absorption large bowel dissolution Ussing chamber swelling fimasartan volume dexketoprofen gastrointestinal simulator transit controlled release formulations experimental and computational permeability methods magnetic resonance imaging GastroPlus™ in vitro–in vivo correlation (IVIVC) diltiazem MRI gut in vitro systems CYP3A4 poorly water-soluble drugs regional absorption intestinal permeability butyric acid intestinal drug absorption gastrointestinal absorption Biopharmaceutics Classification System (BCS) anti-inflammatory in vivo colon microbiota lipid-based formulations in situ single-pass perfusion metabolites biorelevant media fluconazole colon delivery modeling study mathematical modeling motility gellan gum gastrointestinal drug release large intestine lipolysis regional drug absorption thema EDItEUR::M Medicine and Nursing
Online pristup:	44840
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Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches

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