Golgi Pathology in Neurodegenerative Diseases
The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus...
محفوظ في:
| المؤلفون الرئيسيون: | , |
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| التنسيق: | Online |
| اللغة: | الإنجليزية |
| منشور في: |
Frontiers Media SA
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | 18877 |
| الوسوم: |
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| _version_ | 1869518041454215168 |
|---|---|
| author | Catherine Rabouille Georg Haase |
| author_browse | Catherine Rabouille Georg Haase |
| author_facet | Catherine Rabouille Georg Haase |
| author_sort | Catherine Rabouille |
| collection | Directory of Open Access Books |
| description | The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus (fragmentation and atrophy), which are collectively termed Golgi pathology, are now recognized as a constant feature of many neuro-degenerative diseases. However, the molecular mechanisms underlying these changes and their precise relevance to neurodegeneration have not yet been completely elucidated. This eBook contains 13 reviews that address the molecular mechanisms of Golgi pathology in Parkinson and Alzheimer diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophies, and discuss their potential relevance to the pathological loss of neuronal cell bodies, axons and synapses. |
| format | Online |
| id | doab-20.500.12854ir-48746 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-487462024-04-05T12:35:50Z Golgi Pathology in Neurodegenerative Diseases Catherine Rabouille Georg Haase RC321-571 Q1-390 Neurodegenerative Diseases Intracellular membrane traffic Amyotrophic Lateral Sclerosis signaling Golgi fragmentation Microtubules Cell Death Tethers molecular motors vesicles thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus (fragmentation and atrophy), which are collectively termed Golgi pathology, are now recognized as a constant feature of many neuro-degenerative diseases. However, the molecular mechanisms underlying these changes and their precise relevance to neurodegeneration have not yet been completely elucidated. This eBook contains 13 reviews that address the molecular mechanisms of Golgi pathology in Parkinson and Alzheimer diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophies, and discuss their potential relevance to the pathological loss of neuronal cell bodies, axons and synapses. 2021-02-11T14:44:18Z 2021-02-11T14:44:18Z 2016-04-07 11:22:02 2016 book 18877 16648714 9782889197576 https://directory.doabooks.org/handle/20.500.12854/48746 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Golgi_Pathology_in_Neurodegenerative_Diseases/813 http://journal.frontiersin.org/researchtopic/3815/golgi-pathology-in-neurodegenerative-diseases Frontiers Media SA 10.3389/978-2-88919-757-6 10.3389/978-2-88919-757-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197576 119 open access |
| spellingShingle | RC321-571 Q1-390 Neurodegenerative Diseases Intracellular membrane traffic Amyotrophic Lateral Sclerosis signaling Golgi fragmentation Microtubules Cell Death Tethers molecular motors vesicles thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Catherine Rabouille Georg Haase Golgi Pathology in Neurodegenerative Diseases |
| title | Golgi Pathology in Neurodegenerative Diseases |
| title_full | Golgi Pathology in Neurodegenerative Diseases |
| title_fullStr | Golgi Pathology in Neurodegenerative Diseases |
| title_full_unstemmed | Golgi Pathology in Neurodegenerative Diseases |
| title_short | Golgi Pathology in Neurodegenerative Diseases |
| title_sort | golgi pathology in neurodegenerative diseases |
| topic | RC321-571 Q1-390 Neurodegenerative Diseases Intracellular membrane traffic Amyotrophic Lateral Sclerosis signaling Golgi fragmentation Microtubules Cell Death Tethers molecular motors vesicles thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Neurodegenerative Diseases Intracellular membrane traffic Amyotrophic Lateral Sclerosis signaling Golgi fragmentation Microtubules Cell Death Tethers molecular motors vesicles thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18877 |
| work_keys_str_mv | AT catherinerabouille golgipathologyinneurodegenerativediseases AT georghaase golgipathologyinneurodegenerativediseases |