Imatge de la portada

Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autop...

Descripció completa

Guardat en:
Autors principals: Paolo Bonaldo, Luciano Merlini, Emanuele Marzetti
Format: Online
Idioma:anglès
Publicat: Frontiers Media SA 2021
Matèries:
RC321-571
Q1-390
Aging sarcopenia
muscular dystrophy
Mitochondrial dysfunction
therapy
skeletal muscle
Autophagy
Animal Models
Apoptosis
satellite cells
muscle imaging
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
Accés en línia:18814
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
Sumari:Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.

Ítems similars