Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autop...
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| Formaat: | Online |
| Taal: | Engels |
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Frontiers Media SA
2021
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| Online toegang: | 18814 |
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| _version_ | 1869521430815703040 |
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| author | Paolo Bonaldo Luciano Merlini Emanuele Marzetti |
| author_browse | Emanuele Marzetti Luciano Merlini Paolo Bonaldo |
| author_facet | Paolo Bonaldo Luciano Merlini Emanuele Marzetti |
| author_sort | Paolo Bonaldo |
| collection | Directory of Open Access Books |
| description | Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention. |
| format | Online |
| id | doab-20.500.12854ir-55788 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-557882024-04-05T12:36:15Z Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach Paolo Bonaldo Luciano Merlini Emanuele Marzetti RC321-571 Q1-390 Aging sarcopenia muscular dystrophy Mitochondrial dysfunction therapy skeletal muscle Autophagy Animal Models Apoptosis satellite cells muscle imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention. 2021-02-11T22:20:42Z 2021-02-11T22:20:42Z 2016-04-07 11:22:02 2015 book 18814 16648714 9782889196845 https://directory.doabooks.org/handle/20.500.12854/55788 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Pathophysiological_Mechanisms_of_Sarcopenia_in_Aging_and_in_Muscular_Dystrophy_A_Translational_Appr/746#nogo http://journal.frontiersin.org/researchtopic/2299/pathophysiological-mechanisms-of-sarcopenia-in-aging-and-in-muscular-dystrophy-a-translational-appro Frontiers Media SA 10.3389/978-2-88919-684-5 10.3389/978-2-88919-684-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196845 248 open access |
| spellingShingle | RC321-571 Q1-390 Aging sarcopenia muscular dystrophy Mitochondrial dysfunction therapy skeletal muscle Autophagy Animal Models Apoptosis satellite cells muscle imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Paolo Bonaldo Luciano Merlini Emanuele Marzetti Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach |
| title | Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach |
| title_full | Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach |
| title_fullStr | Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach |
| title_full_unstemmed | Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach |
| title_short | Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach |
| title_sort | pathophysiological mechanisms of sarcopenia in aging and in muscular dystrophy a translational approach |
| topic | RC321-571 Q1-390 Aging sarcopenia muscular dystrophy Mitochondrial dysfunction therapy skeletal muscle Autophagy Animal Models Apoptosis satellite cells muscle imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Aging sarcopenia muscular dystrophy Mitochondrial dysfunction therapy skeletal muscle Autophagy Animal Models Apoptosis satellite cells muscle imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18814 |
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