Secretion of Cytokines and Chemokines by Innate Immune Cells
The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through t...
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| Format: | Online |
| Język: | angielski |
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Frontiers Media SA
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | 18159 |
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| _version_ | 1869515621836783616 |
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| author | Paige Lacy |
| author_browse | Paige Lacy |
| author_facet | Paige Lacy |
| author_sort | Paige Lacy |
| collection | Directory of Open Access Books |
| description | The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through the canonical protein trafficking pathway associated with endoplasmic reticulum and Golgi. How cytokines are released upon their exit from the trans-Golgi network varies enormously between cell types, and in many cells this has not yet been characterized. This issue delves into the plethora of cytokines released by innate immune cells, and where possible, shines light on specific mechanisms that regulate trafficking and release of Golgi-derived vesicles. Each cell type also shows varying degrees of dependency on microtubule organization and actin cytoskeleton remodeling for cytokine secretion. Understanding the mechanisms of cytokine secretion will reveal the inner workings of individual innate immune cell types, and allow identification of critical regulatory steps in cytokine release. |
| format | Online |
| id | doab-20.500.12854ir-59083 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-590832024-03-30T23:21:45Z Secretion of Cytokines and Chemokines by Innate Immune Cells Paige Lacy R5-920 RC581-607 secretory granules Dendritic Cells GTPases SNAREs Neutrophils Epithelial Cells degranulation Macrophages Recycling endosomes Eosinophils thema EDItEUR::M Medicine and Nursing The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through the canonical protein trafficking pathway associated with endoplasmic reticulum and Golgi. How cytokines are released upon their exit from the trans-Golgi network varies enormously between cell types, and in many cells this has not yet been characterized. This issue delves into the plethora of cytokines released by innate immune cells, and where possible, shines light on specific mechanisms that regulate trafficking and release of Golgi-derived vesicles. Each cell type also shows varying degrees of dependency on microtubule organization and actin cytoskeleton remodeling for cytokine secretion. Understanding the mechanisms of cytokine secretion will reveal the inner workings of individual innate immune cell types, and allow identification of critical regulatory steps in cytokine release. 2021-02-12T03:10:25Z 2021-02-12T03:10:25Z 2016-01-19 14:05:46 2015 book 18159 16648714 9782889195503 https://directory.doabooks.org/handle/20.500.12854/59083 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Secretion_of_Cytokines_and_Chemokines_by_Innate_Immune_Cells/542#nogo http://journal.frontiersin.org/researchtopic/1912/secretion-of-cytokines-and-chemokines-by-innate-immune-cells Frontiers Media SA 10.3389/978-2-88919-550-3 10.3389/978-2-88919-550-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195503 134 open access |
| spellingShingle | R5-920 RC581-607 secretory granules Dendritic Cells GTPases SNAREs Neutrophils Epithelial Cells degranulation Macrophages Recycling endosomes Eosinophils thema EDItEUR::M Medicine and Nursing Paige Lacy Secretion of Cytokines and Chemokines by Innate Immune Cells |
| title | Secretion of Cytokines and Chemokines by Innate Immune Cells |
| title_full | Secretion of Cytokines and Chemokines by Innate Immune Cells |
| title_fullStr | Secretion of Cytokines and Chemokines by Innate Immune Cells |
| title_full_unstemmed | Secretion of Cytokines and Chemokines by Innate Immune Cells |
| title_short | Secretion of Cytokines and Chemokines by Innate Immune Cells |
| title_sort | secretion of cytokines and chemokines by innate immune cells |
| topic | R5-920 RC581-607 secretory granules Dendritic Cells GTPases SNAREs Neutrophils Epithelial Cells degranulation Macrophages Recycling endosomes Eosinophils thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 secretory granules Dendritic Cells GTPases SNAREs Neutrophils Epithelial Cells degranulation Macrophages Recycling endosomes Eosinophils thema EDItEUR::M Medicine and Nursing |
| url | 18159 |
| work_keys_str_mv | AT paigelacy secretionofcytokinesandchemokinesbyinnateimmunecells |